Early life protein-enriched human milk diets to increase lean body mass accretion and diversity of the gut microbiome in extremely preterm infants: a randomized trial

生命早期富含蛋白质的母乳饮食可增加极早产儿的去脂体重增加和肠道微生物组的多样性:一项随机试验

基本信息

  • 批准号:
    10453715
  • 负责人:
  • 金额:
    $ 16.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-10 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

SUMMARY The purpose of this Mentored Patient-Oriented Research Career Development Award (K23) is to provide Ariel A. Salas, MD, MSPH, with the mentorship, training, and research experience needed to become an independent clinician scientist and leader in neonatal nutrition research. His long-term career goal is to reduce the burden of postnatal growth failure through novel translational studies and large scale, multi-center clinical trials of promising dietary interventions that optimize growth, reduce dysbiosis of the gut microbiome, and ultimately improve neurodevelopment. His immediate goal is to acquire the skills needed to conduct a clinical research program to study the effects of the protein intake and gut microbiome on growth and body composition of extremely preterm infants (28 weeks of gestation or less). To achieve these goals and transition to independence, Dr. Salas and his mentors have developed a comprehensive research and career development plan that includes mentorship from an exceptional team of scientists with proven track records of successful mentorship; intensive didactic training; and a research plan that is purposefully designed to provide experiential learning in advanced research methods to study postnatal growth failure and the gut microbiome of extremely preterm infants. Postnatal growth failure occurs in approximately 60% of the nearly 26,000 extremely preterm infants born every year in the United States. Postnatal growth failure is associated with a higher risk of adverse health outcomes, particularly when fat mass (FM) gains are higher than fat-free mass (FFM) gains. Recent work by Dr. Salas suggests that extremely preterm infants unable to tolerate early progression of enteral feeding volumes during the first 2 weeks after birth have an increased risk of disrupted maturation of the gut microbiome and an increased risk of postnatal growth failure. In the research plan outlined in this K23 proposal, Dr. Salas will expand upon this work by 1) investigating the effects of early postnatal life protein-enriched diets on FFM accretion in extremely preterm infants and 2) identifying maturation patterns of the gut microbiome that differentiate preterm infants with postnatal growth failure and reduced FFM accretion from preterm infants with appropriate postnatal growth and normal FFM accretion. This work will produce novel insights into the pathogenesis of postnatal growth failure in preterm infants and will serve as the foundation for Dr. Salas to inform his future R01 proposals and discover new, evidence-based approaches to prevent postnatal growth failure. His career development plan outlines a clear path to gain the knowledge, skills, and experience needed to become an independent clinician scientist, leader, and innovator in neonatal nutrition research.
总结 这个指导患者为导向的研究职业发展奖(K23)的目的是提供阿里尔 A.萨拉斯,医学博士,MSPH,与导师,培训和研究经验,需要成为一个 独立临床科学家和新生儿营养研究的领导者。他的长期职业目标是减少 通过新的转化研究和大规模、多中心临床研究, 有希望的饮食干预试验,优化生长,减少肠道微生物组的生态失调, 最终促进神经发育。他的近期目标是获得进行临床研究所需的技能。 研究计划,研究蛋白质摄入量和肠道微生物对生长和身体的影响 极早产儿(妊娠28周或以下)的组成。为了实现这些目标和过渡 从独立到独立,萨拉斯博士和他的导师已经发展了全面的研究和职业生涯 发展计划,其中包括一个杰出的科学家团队的指导, 成功的指导;密集的教学培训;以及有目的地设计的研究计划,以提供 体验学习先进的研究方法,以研究出生后生长失败和肠道微生物组 极早产儿在近26,000名婴儿中,约有60%发生产后生长障碍。 在美国,每年都有极早产儿出生。出生后生长障碍与 不良健康结果的风险更高,特别是当脂肪量(FM)增加高于无脂肪量时 (FFM)收益.萨拉斯博士最近的研究表明,极早产儿不能耐受早期 在出生后的前2周内,肠内喂养量的增加会增加中断的风险。 肠道微生物组的成熟和出生后生长失败的风险增加。在研究计划中 在这个K23的建议概述,萨拉斯博士将扩大这项工作,1)调查的影响,早期 出生后生活中富含蛋白质的饮食对极早产儿FFM增长的影响; 2)识别成熟 区分早产儿与出生后生长障碍和FFM减少的肠道微生物组模式 来自具有适当的出生后生长和正常FFM增生的早产儿的增生。这项工作将 对早产儿出生后生长障碍的发病机制产生新的见解,并将作为 基金会为萨拉斯博士告知他未来的R 01提案,并发现新的,以证据为基础的方法, 预防产后发育不良。他的职业发展计划概述了一条获得知识的明确道路, 技能和经验,需要成为一个独立的临床科学家,领导者和创新者在新生儿 营养研究。

项目成果

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Ariel Salas其他文献

Ariel Salas的其他文献

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{{ truncateString('Ariel Salas', 18)}}的其他基金

Early life protein-enriched human milk diets to increase lean body mass accretion and diversity of the gut microbiome in extremely preterm infants: a randomized trial
生命早期富含蛋白质的母乳饮食可增加极早产儿的去脂体重增加和肠道微生物组的多样性:一项随机试验
  • 批准号:
    10039996
  • 财政年份:
    2020
  • 资助金额:
    $ 16.22万
  • 项目类别:
Early life protein-enriched human milk diets to increase lean body mass accretion and diversity of the gut microbiome in extremely preterm infants: a randomized trial
生命早期富含蛋白质的母乳饮食可增加极早产儿的去脂体重增加和肠道微生物组的多样性:一项随机试验
  • 批准号:
    10664900
  • 财政年份:
    2020
  • 资助金额:
    $ 16.22万
  • 项目类别:

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