Understanding Oral Anticancer Medication Adherence among Patients with Multiple Myeloma

了解多发性骨髓瘤患者口服抗癌药物的依从性

• 批准号: 10453641
• 负责人: Sarah M. Belcher
• 金额: $ 12.05万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10453641
• 关键词: Adherence; Adult; Advanced Malignant Neoplasm; Affect; African American population; Behavioral; Cancer Etiology; Cancer Survivor; Chronic Disease; Clinical; Common Terminology Criteria for Adverse Events; Data; Development; Diagnosis; Disease Progression; Environment; European Organization for Research and Treatment of Cancer; Financial Hardship; Future; Goals; Grant; Health; Health Care Costs; Hematopoietic Neoplasms; Household; Income; Individual; Intervention; Interview; K-Series Research Career Programs; Knowledge; Lead; Life; Maintenance Therapy; Malignant Neoplasms; Measurement; Measures; Mental Health; Mentorship; Methods; Mission; Modeling; Multiple Myeloma; National Institute of Nursing Research; Oral; Outcome; Pain; Pain quality; Participant; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Pattern; Pharmaceutical Preparations; Pilot Projects; Plasma Cells; Population; Program Sustainability; Qualitative Methods; Quality of life; Reporting; Research; Research Methodology; Research Project Grants; Resources; Risk; Sampling; Scientist; Statistical Methods; Structure; Symptoms; Testing; Time; Training; Training Activity; United States National Institutes of Health; Universities; Vulnerable Populations; Work; anti-cancer; base; bone; cancer care; cancer therapy; career development; clinically relevant; cost; design; disorder control; experience; financial toxicity; improved; instrument; low socioeconomic status; markov model; medication compliance; medication nonadherence; mortality; multidisciplinary; pain reduction; patient oriented research; physical conditioning; pill; prospective; reduce symptoms; research study; skills; social factors; socioeconomics; standard of care; statistics; systematic review; therapy development

PROJECT SUMMARY This K23 application support's the applicant's long-term goal to build an independent, sustained program of research leading patient-oriented research studies focused on improving medication adherence and health outcomes among socioeconomically diverse patients with cancer. Cancer treatment advances, including costly, long-term therapy with oral anticancer medication, have extended survival for patients with cancer, including those with multiple myeloma, a life-threatening blood cancer associated with significant pain and reduced quality of life. Improved knowledge of how oral anticancer medication adherence influences patient health outcomes over time and how financial hardship may affect these relationships will inform future large- scale studies aimed at developing timely, targeted interventions to improve adherence, reduce pain, and improve quality of life in patients with cancer. This career development award will support the applicant's training and research goals through focused, expert mentorship, coursework, and other training activities designed to 1) develop theoretical and measurement knowledge specific to medication adherence research; 2) develop statistical and qualitative methods expertise needed to conduct longitudinal, mixed method research; and 3) gain in-depth knowledge and research skills to conduct culturally-sensitive research with vulnerable populations. The proposed research project will generate knowledge about temporal relationships among adherence, financial hardship, pain, and quality of life in patients initiating long-term oral anticancer medication for multiple myeloma. Utilizing a longitudinal, mixed method design in a sample of 90 socioeconomically diverse patients newly prescribed oral anticancer maintenance therapy for multiple myeloma with repeated measure assessment at baseline, 3-months, and 6-months post therapy initiation, the study aims to 1) prospectively determine the influence of oral anticancer medication adherence on pain and quality of life; 2) determine whether financial hardship moderates the relationship between oral anticancer medication adherence and pain and quality of life over time; and 3) explore the patient experience of taking oral anticancer medication using qualitative methods in a subset of participants with differing adherence patterns. Descriptive statistics, mixed-effects modeling, and lagged value effects using Markov modeling will be used to achieve aims 1 and 2, respectively. Qualitative description and content analysis will be used to achieve aim 3. This proposal directly aligns with the National Institute of Nursing Research's mission to understand the behavioral aspects of symptoms to improve health outcomes and quality of life. Emory University's research environment provides strong resources that will facilitate Dr. Belcher's career development into an independent research scientist.

项目总结

项目成果

Domains of Structured Oral Anticancer Medication Programs: A Scoping Review.

• DOI: 10.1188/22.onf.296-306
• 发表时间: 2022-06-17
• 期刊: ONCOLOGY NURSING FORUM
• 影响因子: 1.9
• 作者: Sivakumaran, Kapeena;Ginex, Pamela K.;Waseem, Haya;Belcher, Sarah M.;Lagler-Clark, Sarah;LeFebvre, Kristine B.;Palmer, Nicole;Pasumarthi, Tejanth;Morgan, Rebecca L.
• 通讯作者: Morgan, Rebecca L.

ONS Guidelines™ to Support Patient Adherence to Oral Anticancer Medications.

• DOI: 10.1188/22.onf.279-295
• 发表时间: 2022-06-17
• 期刊: ONCOLOGY NURSING FORUM
• 影响因子: 1.9
• 作者: Belcher, Sarah M.;Mackler, Emily;Muluneh, Benyam;Ginex., Pamela K.;Anderson, Mary K.;Bettencourt, Elizabeth;DasGupta, Ryan K.;Elliott, Jennifer;Hall, Erica;Karlin, Michelle;Kostoff, Diana;Marshall, Victoria K.;Millisor, Vanessa E.;Molnar, Maegan;Schneider, Susan M.;Tipton, Janelle;Yackzan, Susan;LeFebvre, Kristine B.;Sivakumaran, Kapeena;Waseem, Haya;Morgan, Rebecca L.
• 通讯作者: Morgan, Rebecca L.