BLR&D Research Career Scientist Award Application for Xiao-Ming Xu, PhD

BLR

基本信息

  • 批准号:
    10454214
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-04-01 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

My VA-related research focuses on studying traumatic spinal cord injury (SCI), which is among the most disabling conditions affecting wounded members of the U.S. military. Although survival rates for SCI remain high, the devastating nature of the injury results in substantial disability, which must be borne by the injured veterans, their families, and the VA health-care system. Unfortunately, there has been no effective treatment available for patients with acute and chronic SCIs. Therefore, developing novel treatment strategies is imperative to mitigate the devastating nature and improve quality of life for our veterans with SCI. The goal of my research is to study molecular mechanisms underlying traumatic SCI and develop novel repair strategies to promote regeneration of the injured spinal cord and enhance functional recovery in experimental models of SCI. My long-term goal is to translate effective treatment strategies from animal models to humans, including our veterans. To reach these goals, I conduct VA-related research in 3 major areas. In the first research area (supported by VA I01 BX002356-01 and I01 BX002356-04), my lab is testing an innovative hypothesis that a growth-promoting pathway, composed of grafted Schwann cells (SCs, a type of peripheral supporting cells) overexpressing a trophic factor called glial cell line-derived neurotrophic factor (GDNF), will promote the growth of descending spinal nerve fibers across an injury gap to project to the distal host spinal cord. These regenerated nerve fibers will form target-specific connections with lumbar motoneurons (MNs) overexpressing another neurotrophic factor called neurotrophin-3 (NT-3). We also hypothesize that such a combinatorial approach will lead to greater functional recovery than any single treatment alone. Completion of this proposal will allow us to reveal mechanisms fundamental to rebuilding neural circuitry of the descending spinal cord pathways and to identify new therapeutic strategies for functional recovery after SCI. In the second research area (supported by VA I01 BX003705-01A1), we propose to investigate whether a novel lipid signaling pathway, namely the cardiolipin (CL)- cytochrome c pathway, plays a role in mediating cell death, tissue damage, and functional loss after SCI. Specifically, we will determine the treatment effect of a new mitochondrial targeted antioxidant compound XJB and its molecular mechanism underlying functional recovery after a clinically-relevant contusive SCI in adult rats. In the third research area (supported by VA ShEEP 1IS1 BX004405-01), I have secured funding to purchase an UltraMicroscope II Light Sheet Fluorescence Microscope (LSFM) for use by 9 VA-funded investigators with different research disciplines including neural, muscle, and bone biology within the NeuroMusculoSkeletal (NMS) Research Program at the Roudebush VAMC in Indianapolis. The LSFM is an innovative device that overcomes many limitations of currently used conventional approaches and will advance science with high quality, efficiency, precision, and productivity. The overall objective of obtaining this LSFM is to create new collaborations among funded VA investigators that lead to innovative solutions for health problems facing our veterans.
我的va相关研究重点是研究创伤性脊髓损伤(SCI),这是最致残的

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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XIAO-MING XU其他文献

XIAO-MING XU的其他文献

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{{ truncateString('XIAO-MING XU', 18)}}的其他基金

Reprogramming reactive glial cells into functional new neurons after SCI
SCI 后将反应性神经胶质细胞重编程为功能性新神经元
  • 批准号:
    10218281
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Reprogramming reactive glial cells into functional new neurons after SCI
SCI 后将反应性神经胶质细胞重编程为功能性新神经元
  • 批准号:
    10055803
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Exercise and NT-3-mediated lumbar motoneuron plasticity and recovery after SCI
SCI 后运动和 NT-3 介导的腰椎运动神经元可塑性和恢复
  • 批准号:
    10088336
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
BLR&D Research Career Scientist Award Application for Xiao-Ming Xu, PhD
BLR
  • 批准号:
    9911971
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
BLR&D Research Career Scientist Award Application for Xiao-Ming Xu, PhD
BLR
  • 批准号:
    10265418
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
BLR&D Research Career Scientist Award Application for Xiao-Ming Xu, PhD
BLR
  • 批准号:
    9764746
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Cardiolipin as a Novel Target for Neuroprotection after Spinal Cord Injury
心磷脂作为脊髓损伤后神经保护的新靶点
  • 批准号:
    10084223
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
Role of phospholipase A2 in spinal cord secondary injury
磷脂酶A2在脊髓继发性损伤中的作用
  • 批准号:
    8494696
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Role of phospholipase A2 in spinal cord secondary injury
磷脂酶A2在脊髓继发性损伤中的作用
  • 批准号:
    8305087
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Role of phospholipase A2 in spinal cord secondary injury
磷脂酶A2在脊髓继发性损伤中的作用
  • 批准号:
    7787702
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:

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