Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury

活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响

基本信息

  • 批准号:
    10453771
  • 负责人:
  • 金额:
    $ 38.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-23 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Abstract Bladder and bowel complications have consistently been rated as of the upmost importance by the spinal cord injury (SCI) population. Importantly, both bladder and bowel distention have been identified as primary triggers of autonomic dysreflexia (AD) in individuals with cervical and upper thoracic level lesions (majority of SCI population), a systolic blood pressure rising often more than 20 mmHg and remaining at these values with intolerable symptoms (pounding headache and/or chills, for example). We have recently documented as part of our current R01 this massive unmodulated sympathetic reflex which causes widespread vasoconstriction (presenting as severe hypertension) as a limitation for bladder capacity in numerous research participants. Anecdotally, many who use clean intermittent catheterization for bladder management report using AD symptoms daily as a signal of bladder fullness and time for emptying, an unsafe practice that needs addressing. Additionally, we and others have documented in questionnaires regular occurrences of AD symptoms during bowel programs and in ongoing lab-based studies there have been numerous instances of AD upon insertion of a rectal probe either for bladder cystometry (for recording abdominal pressure) or during anorectal manometry. The goals of the current multi-disciplinary study incorporating critical cross viscero- visceral intersystem interactions are 1) to investigate in a controlled laboratory setting and then with mobile at-home monitoring the extent, severity and frequency of occurrence of AD with respect to daily bladder and bowel function, in conjunction with identifying potential underlying mechanisms by examining urinary biomarkers for several specific vasoactive hormones, and 2) to regulate cardiovascular (CV) function therapeutically as part of bladder and bowel management using spinal cord epidural stimulation, which our CV team have shown can normalize blood pressure.
摘要

项目成果

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SUSAN J HARKEMA其他文献

SUSAN J HARKEMA的其他文献

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{{ truncateString('SUSAN J HARKEMA', 18)}}的其他基金

Functional Mapping with Lumbosacral Epidural Stimulation for Restoration of Bladder Function After Spinal Cord Injury
腰骶部硬膜外刺激功能标测用于脊髓损伤后膀胱功能的恢复
  • 批准号:
    10455251
  • 财政年份:
    2017
  • 资助金额:
    $ 38.34万
  • 项目类别:
Functional Mapping with Lumbosacral Epidural Stimulation for Restoration of Bladder Function After Spinal Cord Injury
腰骶部硬膜外刺激功能标测用于脊髓损伤后膀胱功能的恢复
  • 批准号:
    10005625
  • 财政年份:
    2017
  • 资助金额:
    $ 38.34万
  • 项目类别:
Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury
活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响
  • 批准号:
    10228656
  • 财政年份:
    2014
  • 资助金额:
    $ 38.34万
  • 项目类别:
Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury
活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响
  • 批准号:
    10663193
  • 财政年份:
    2014
  • 资助金额:
    $ 38.34万
  • 项目类别:
Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury
活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响
  • 批准号:
    9093814
  • 财政年份:
    2014
  • 资助金额:
    $ 38.34万
  • 项目类别:
PLASTICITY OF HUMAN SPINAL NEURAL NETWORKS AFTER INJURY
人类脊髓神经网络受伤后的可塑性
  • 批准号:
    7955656
  • 财政年份:
    2009
  • 资助金额:
    $ 38.34万
  • 项目类别:
PLASTICITY OF HUMAN SPINAL NEURAL NETWORKS AFTER INJURY
人类脊髓神经网络受伤后的可塑性
  • 批准号:
    7724333
  • 财政年份:
    2008
  • 资助金额:
    $ 38.34万
  • 项目类别:
CORE--DATA PROCESSING AND BIOSTATISTICAL CORE
核心——数据处理和生物统计核心
  • 批准号:
    7436281
  • 财政年份:
    2007
  • 资助金额:
    $ 38.34万
  • 项目类别:
ACTIVITY DEPENDENT PLASTICITY AFTER HUMAN SPINAL CORD INJURY
人类脊髓损伤后的活动依赖性可塑性
  • 批准号:
    7436279
  • 财政年份:
    2007
  • 资助金额:
    $ 38.34万
  • 项目类别:
PLASTICITY OF HUMAN SPINAL NEURAL NETWORKS AFTER INJURY
人类脊髓神经网络受伤后的可塑性
  • 批准号:
    7627689
  • 财政年份:
    2007
  • 资助金额:
    $ 38.34万
  • 项目类别:

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