Early life exposure to agricultural pesticides and functional brain imaging in young adults
Early life exposure to agricultural pesticides and functional brain imaging in young adults
批准号:
10455703
负责人:
Allan L Reiss
金额:
$23.89万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-01 至 2024-05-31
关键词:
14 year old19 year old5 year oldAdolescenceAffectAgeAgricultureAttentionBehavioralBiological MarkersBirthBrainBrain imagingBrain regionCaliforniaChildChildhoodChlorpyrifosClinical ResearchCognitiveCohort StudiesDataData ReportingDatabasesDevelopmentDiseaseEnvironmental ExposureExposure toFunctional Magnetic Resonance ImagingFutureHealthImpairmentIndividualInsecticidesInvestigationKnowledgeLifeLinkLiteratureMagnetic Resonance ImagingMeasuresMexican AmericansMothersMovementNew York CityOrganophosphatesParietalParticipantPatternPesticidesPopulationPregnancyProblem behaviorReportingResearchSalinas ValleySamplingShort-Term MemorySourceStructureTechnologyTestingThickWorkYouthagricultural communityagricultural pesticideautisticbasecognitive functioncognitive taskcohortcostcritical perioddevelopmental diseaseearly childhoodearly life exposureexecutive functionflexibilityfunctional near infrared spectroscopyhealth assessmentinorganic phosphatelanguage comprehensionmultidimensional dataneurobehavioral testneurodevelopmentneuroimagingneuromechanismneuropsychiatric disorderneurotoxicpesticide exposurepopulation basedportabilityprenatalprenatal exposurerelating to nervous systemresearch studyresidencetoxic organophosphate insecticide exposuretraiturinaryyoung adult
中文摘要
摘要
有机磷(OP)农药是广泛使用的杀虫剂。自1999年以来,我们的健康中心
萨利娜母亲和儿童评估(CHAMACOS)研究一直在评估以下物质对健康的影响
在加利福尼亚州农业萨利纳斯山谷,约600名墨西哥裔美国青年出生时使用了有机磷杀虫剂。
我们已经报道了产前接触有机磷农药与较差的认知功能和行为能力的关系
从儿童早期到青春期的问题。使用神经成像进行进一步的研究对于
阐明:1)OP对大脑的哪些结构和功能有不利影响;以及2)OP相关
对大脑功能的影响,在使用标准神经行为测试的研究中可能没有检测到。只有两个
神经影像研究报告了与早期生命有机磷农药暴露的相关性。第一个包括一群
40名纽约市儿童,他们发现产前接触OP毒死蜱与减少
结构磁共振成像显示额叶、颞叶和顶叶的皮质厚度
(核磁共振)。在95名CHAMACOS参与者中,我们发现怀孕期间居住在靠近OP的地方
与功能性近红外光谱(FNIRS)观察到的大脑激活模式的改变有关
在执行职能的任务中。这些初步发现需要在更大的样本中得到证实
在大脑发育的关键窗口期间进行高质量的暴露评估。在这个项目中,我们建议
研究生命早期接触有机磷农药对神经激活模式和功能的影响
在整个CHAMACOS青年队列(18-19岁)之间的连接性。我们收集了
使用功能近红外光谱(FNIRS)的神经成像数据--一种成本独特的fMRI替代方法
以及实地研究的便利优势--在CHAMACOS队列的458名参与者中。我们
评估受试者完成下列任务时前额叶、颞叶和顶叶脑区的神经活动
认知灵活性、工作记忆和语言理解。对于约300名CHAMACOS参与者,我们
已经在母亲产前和早期分析了二烷基磷酸盐(DAP),这是一种非特异性OP生物标记物
儿童(6个月-5岁)尿样。对于所有458名参与者,我们估计接触到
基于居民区对农业有机磷农药的接近程度的单种有机磷农药及其混合物
使用加州独特的农药使用报告(PUR)数据库的应用程序。尿DAP和PUR数据
提供补充暴露措施,以便更全面地审查
在发展的关键时期,来自不同来源的有机磷农药。对于这个项目,我们建议
对这些多维数据进行密集处理,并调查与早期生命操作的关联
使用fNIRS研究农药暴露与皮质神经激活和功能连接的关系。我们的建议
这将是使用功能神经成像来评估农药暴露影响的最大规模的研究,也是第一个
应用fNIRS技术定位与环境暴露相关的神经发育损害。
英文摘要
ABSTRACT
Organophosphate (OP) pesticides are widely used insecticides. Since 1999, our Center for the Health
Assessment of Mothers and Children of Salinas (CHAMACOS) study has been assessing the health effects of
OP pesticides among a birth cohort of ~600 Mexican American youth in California’s agricultural Salinas Valley.
We have reported associations of prenatal OP pesticide exposure with poorer cognitive function and behavioral
problems from early childhood through adolescence. Further investigation using neuroimaging is important for
elucidating: 1) which structures and functions in the brain are adversely affected by OPs; and, 2) OP-related
impacts on brain function that may be undetected in studies using standard neurobehavioral tests. Only two
neuroimaging studies report associations with of early life OP pesticide exposure. The first includes a cohort of
40 New York City children, which found associations of prenatal exposure to the OP chlorpyrifos with reduced
cortical thickness of frontal, temporal, and parietal regions shown by structural magnetic resonance imaging
(MRI). In a subset of 95 CHAMACOS participants we found that residential proximity to OP use during pregnancy
was associated with altered brain activation patterns observed with functional near infrared spectroscopy (fNIRS)
during tasks of executive function. These preliminary findings warrant corroboration among a larger sample with
high quality exposure assessment during critical windows of brain development. In this project, we propose to
investigate associations of early life exposure to OP pesticides on neural activation patterns and functional
connectivity among the entire CHAMACOS cohort of young adults (18-19 years old).We have collected
neuroimaging data using functional near-infrared spectroscopy (fNIRS) – an alternative to fMRI with distinct cost
and convenience advantages for field-based research – in 458 participants of the CHAMACOS cohort. We
assessed neural activity in the prefrontal, temporal and parietal brain regions as participants complete tasks of
cognitive flexibility, working memory, and language comprehension. For ~300 CHAMACOS participants, we
have already analyzed dialkyl phosphates (DAPs), non-specific OP biomarkers, in maternal prenatal and early
childhood (6 months – 5 years) urinary samples. For all 458 participants, we have estimated exposure to
individual OP pesticides and their mixtures based on residential proximity to agricultural OP pesticide
applications using California’s unique Pesticide Use Reporting (PUR) database. Urinary DAPs and PUR data
provide complementary exposure measures, allowing for a more comprehensive examination of the effects of
OP pesticides from different sources during critical periods of development. For this project, we propose to
conduct the intensive processing of these multi-dimensional data and investigate associations of early life OP
pesticides exposure with cortical neural activation and functional connectivity using fNIRS. Our proposed
research will be the largest to assess impacts of pesticide exposure using functional neuroimaging, and the first
to apply fNIRS technology to localize impairments in neurodevelopment related to an environmental exposure.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.neuro.2022.10.004
发表时间:
2022-12
期刊:
NEUROTOXICOLOGY
影响因子:
3.4
作者:
[Mora, Ana M., Baker, Joseph M., Hyland, Carly, Rodriguez-Zamora, Maria G., Rojas-Valverde, Daniel, Winkler, Mirko S., Staudacher, Philipp, Palzes, Vanessa A., Gutierrez-Vargas, Randall, Lindh, Christian, Reiss, Allan L., Eskenazi, Brenda, Fuhrimann, Samuel, Sagiv, Sharon K.]
通讯作者:
Sagiv, Sharon K.
Developmental trajectory of anxiety, avoidance, and arousal in girls with the FMR1 full mutation
-
批准号:10576763
-
项目类别:
-
资助金额:$22.92万
-
财政年份:2022
-
负责人:Allan L Reiss
-
依托单位:
Early life exposure to agricultural pesticides and functional brain imaging in young adults
-
批准号:10303593
-
项目类别:
-
资助金额:$21.38万
-
财政年份:2021
-
负责人:Allan L Reiss
-
依托单位:
Brain and Behavior during Puberty in Klinefelter Syndrome
-
批准号:10197985
-
项目类别:
-
资助金额:$61.14万
-
财政年份:2018
-
负责人:Allan L Reiss
-
依托单位:
Brain and Behavior during Puberty in Klinefelter Syndrome.
-
批准号:10658503
-
项目类别:
-
资助金额:$33.11万
-
财政年份:2018
-
负责人:Allan L Reiss
-
依托单位:
Brain and Behavior during Puberty in Klinefelter Syndrome
-
批准号:9766339
-
项目类别:
-
资助金额:$62.38万
-
财政年份:2018
-
负责人:Allan L Reiss
-
依托单位:
Brain and Behavior during Puberty in Klinefelter Syndrome
-
批准号:10430045
-
项目类别:
-
资助金额:$61.14万
-
财政年份:2018
-
负责人:Allan L Reiss
-
依托单位:
Brain Development & Sex Chromosomes: Imaging of Turner and Klinefelter Syndromes
-
批准号:8443566
-
项目类别:
-
资助金额:$23.55万
-
财政年份:2013
-
负责人:Allan L Reiss
-
依托单位:
Brain Development & Sex Chromosomes: Imaging of Turner and Klinefelter Syndromes
-
批准号:8653989
-
项目类别:
-
资助金额:$19.63万
-
财政年份:2013
-
负责人:Allan L Reiss
-
依托单位:
LONGITUDINAL OUTCOMES & NEUROIMAGING OF FRAGILE X SYND
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批准号:8363425
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项目类别:
-
资助金额:$0.51万
-
财政年份:2011
-
负责人:Allan L Reiss
-
依托单位:
LONGITUDINAL OUTCOMES & NEUROIMAGING OF FRAGILE X SYND
-
批准号:8171029
-
项目类别:
-
资助金额:$1.22万
-
财政年份:2010
-
负责人:Allan L Reiss
-
依托单位:
OVERDRIVE OF HUMOR-RELATED BRAIN RESPONSES IN CATAPLEXY
-
批准号:8169851
-
项目类别:
-
资助金额:$1.23万
-
财政年份:2010
-
负责人:Allan L Reiss
-
依托单位:
Augmentation of the Cholinergic System in Fragile X Syndrome: A Double-Blind Plac
-
批准号:7937764
-
项目类别:
-
资助金额:$24.0万
-
财政年份:2009
-
负责人:Allan L Reiss
-
依托单位:
Augmentation of the Cholinergic System in Fragile X Syndrome: A Double-Blind Plac
-
批准号:7844289
-
项目类别:
-
资助金额:$24.0万
-
财政年份:2009
-
负责人:Allan L Reiss
-
依托单位:
Gene, Brain and Behavior in Turner Syndrome
-
批准号:7935087
-
项目类别:
-
资助金额:$28.31万
-
财政年份:2009
-
负责人:Allan L Reiss
-
依托单位:
Augmentation of the Cholinergic System in Fragile X Syndrome: A Double-Blind Plac
-
批准号:8085901
-
项目类别:
-
资助金额:$23.76万
-
财政年份:2009
-
负责人:Allan L Reiss
-
依托单位:
OVERDRIVE OF HUMOR-RELATED BRAIN RESPONSES IN CATAPLEXY
-
批准号:7955377
-
项目类别:
-
资助金额:$1.2万
-
财政年份:2009
-
负责人:Allan L Reiss
-
依托单位:
LONGITUDINAL OUTCOMES & NEUROIMAGING OF FRAGILE X SYND
-
批准号:7955636
-
项目类别:
-
资助金额:$1.36万
-
财政年份:2009
-
负责人:Allan L Reiss
-
依托单位:
LONGITUDINAL OUTCOMES & NEUROIMAGING OF FRAGILE X SYND
-
批准号:7724296
-
项目类别:
-
资助金额:$1.02万
-
财政年份:2008
-
负责人:Allan L Reiss
-
依托单位:
OVERDRIVE OF HUMOR-RELATED BRAIN RESPONSES IN CATAPLEXY
-
批准号:7722907
-
项目类别:
-
资助金额:$0.28万
-
财政年份:2008
-
负责人:Allan L Reiss
-
依托单位:
Cortical complexity in children with Autism unaffected Siblings and Controls
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批准号:7635850
-
项目类别:
-
资助金额:$7.9万
-
财政年份:2008
-
负责人:Allan L Reiss
-
依托单位:
海外基金