Early life exposure to agricultural pesticides and functional brain imaging in young adults

年轻成人早期接触农业农药和功能性脑成像

• 批准号: 10455703
• 负责人: Allan L Reiss
• 金额: $ 23.89万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10455703
• 关键词: 14 year old; 19 year old; 5 year old; Adolescence; Affect; Age; Agriculture; Attention; Behavioral; Biological Markers; Birth; Brain; Brain imaging; Brain region; California; Child; Childhood; Chlorpyrifos; Clinical Research; Cognitive; Cohort Studies; Data; Data Reporting; Databases; Development; Disease; Environmental Exposure; Exposure to; Functional Magnetic Resonance Imaging; Future; Health; Impairment; Individual; Insecticides; Investigation; Knowledge; Life; Link; Literature; Magnetic Resonance Imaging; Measures; Mexican Americans; Mothers; Movement; New York City; Organophosphates; Parietal; Participant; Pattern; Pesticides; Population; Pregnancy; Problem behavior; Reporting; Research; Salinas Valley; Sampling; Short-Term Memory; Source; Structure; Technology; Testing; Thick; Work; Youth; agricultural community; agricultural pesticide; autistic; base; cognitive function; cognitive task; cohort; cost; critical period; developmental disease; early childhood; early life exposure; executive function; flexibility; functional near infrared spectroscopy; health assessment; inorganic phosphate; language comprehension; multidimensional data; neurobehavioral test; neurodevelopment; neuroimaging; neuromechanism; neuropsychiatric disorder; neurotoxic; pesticide exposure; population based; portability; prenatal; prenatal exposure; relating to nervous system; research study; residence; toxic organophosphate insecticide exposure; trait; urinary; young adult

ABSTRACT Organophosphate (OP) pesticides are widely used insecticides. Since 1999, our Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study has been assessing the health effects of OP pesticides among a birth cohort of ~600 Mexican American youth in California’s agricultural Salinas Valley. We have reported associations of prenatal OP pesticide exposure with poorer cognitive function and behavioral problems from early childhood through adolescence. Further investigation using neuroimaging is important for elucidating: 1) which structures and functions in the brain are adversely affected by OPs; and, 2) OP-related impacts on brain function that may be undetected in studies using standard neurobehavioral tests. Only two neuroimaging studies report associations with of early life OP pesticide exposure. The first includes a cohort of 40 New York City children, which found associations of prenatal exposure to the OP chlorpyrifos with reduced cortical thickness of frontal, temporal, and parietal regions shown by structural magnetic resonance imaging (MRI). In a subset of 95 CHAMACOS participants we found that residential proximity to OP use during pregnancy was associated with altered brain activation patterns observed with functional near infrared spectroscopy (fNIRS) during tasks of executive function. These preliminary findings warrant corroboration among a larger sample with high quality exposure assessment during critical windows of brain development. In this project, we propose to investigate associations of early life exposure to OP pesticides on neural activation patterns and functional connectivity among the entire CHAMACOS cohort of young adults (18-19 years old).We have collected neuroimaging data using functional near-infrared spectroscopy (fNIRS) – an alternative to fMRI with distinct cost and convenience advantages for field-based research – in 458 participants of the CHAMACOS cohort. We assessed neural activity in the prefrontal, temporal and parietal brain regions as participants complete tasks of cognitive flexibility, working memory, and language comprehension. For ~300 CHAMACOS participants, we have already analyzed dialkyl phosphates (DAPs), non-specific OP biomarkers, in maternal prenatal and early childhood (6 months – 5 years) urinary samples. For all 458 participants, we have estimated exposure to individual OP pesticides and their mixtures based on residential proximity to agricultural OP pesticide applications using California’s unique Pesticide Use Reporting (PUR) database. Urinary DAPs and PUR data provide complementary exposure measures, allowing for a more comprehensive examination of the effects of OP pesticides from different sources during critical periods of development. For this project, we propose to conduct the intensive processing of these multi-dimensional data and investigate associations of early life OP pesticides exposure with cortical neural activation and functional connectivity using fNIRS. Our proposed research will be the largest to assess impacts of pesticide exposure using functional neuroimaging, and the first to apply fNIRS technology to localize impairments in neurodevelopment related to an environmental exposure.

摘要

项目成果

Pesticide exposure and cortical brain activation among farmworkers in Costa Rica.

• DOI: 10.1016/j.neuro.2022.10.004
• 发表时间: 2022-12
• 期刊: NEUROTOXICOLOGY
• 影响因子: 3.4
• 作者: Mora, Ana M.;Baker, Joseph M.;Hyland, Carly;Rodriguez-Zamora, Maria G.;Rojas-Valverde, Daniel;Winkler, Mirko S.;Staudacher, Philipp;Palzes, Vanessa A.;Gutierrez-Vargas, Randall;Lindh, Christian;Reiss, Allan L.;Eskenazi, Brenda;Fuhrimann, Samuel;Sagiv, Sharon K.
• 通讯作者: Sagiv, Sharon K.