OVERDRIVE OF HUMOR-RELATED BRAIN RESPONSES IN CATAPLEXY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 发作性睡病是一种睡眠障碍，每2,000人中就有1人患有这种疾病。紧张症通常是由强烈的情绪引发的，比如与笑声有关的情绪。 具体目标： 研究发作性睡病患者幽默处理的神经系统。 研究方法： 我们对24名患有和不患有嗜睡症的人进行了功能性磁共振成像（fMRI）研究，同时他们观看了有趣的动画片。我们还单独检查了一名在扫描过程中经历过痉挛发作的受试者，并与健康人和嗜睡症患者进行了比较。我们测量了他们对漫画（所有受试者）和痉挛症状（患者）的主观评价。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cataplexy is a core symptom of narcolepsy, a sleep disorder affecting 1 in 2,000 persons. Cataplexy is most often triggered by strong emotions such as those associated with laughter. Specific Aims: To examine neural systems underlying humor processing in individuals with narcolepsy. Methods: We performed a functional magnetic resonance imaging (fMRI) study in 24 individuals with and without narcolepsy while they watched funny still cartoons. We also examined separately, a subject who experienced a cataplectic attack during the scan and compared both with healthy and with narcolepsy individuals. We measured their subjective ratings of funniness of the cartoons (in all subjects) and cataplectic symptoms (in the patients).