Resident Memory T Cells

常驻记忆T细胞

• 批准号: 10455752
• 负责人: DAVID MASOPUST
• 金额: $ 60.46万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-19 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10455752
• 关键词: Address; Adoptive Cell Transfers; Allergic; Anatomy; Autoimmune; Back; Biology; Blood; Cells; Data; Dependence; Development; Disease; Epigenetic Process; Event; Exhibits; Goals; Growth; Homing; Human; Immune response; Immunity; Immunologic Surveillance; Infection; Inflammatory; Knowledge; Longevity; Lymphocyte; Maintenance; Malignant Neoplasms; Memory; Methods; Modeling; Parabiosis; Phase; Play; Population; Role; Site; T memory cell; T-Lymphocyte; Testing; Therapeutic; Tissues; Update; Vaccination; Vaccines; base; developmental plasticity; experimental study; innovation; lymph nodes; migration; programs; reconstitution; residence; secondary lymphoid organ

Project Summary The goal of this proposal is to make significant advancements in our understanding of resident memory T cell (TRM) biology that will inform mechanisms of immunity and vaccination. TRM longevity and stability will be rigorously examined. Moreover, the proposal will test the hypothesis that TRM exhibit developmental plasticity and retrograde migration, giving rise to cells contained within circulating T cell populations that are significantly advantaged to reconstitute TRM-based immunity specifically at their previous site of residence. Lastly, the ontogeny and function of lymph node TRM will be defined.

项目总结