课题基金 / 基金详情

Resident Memory T Cells

Resident Memory T Cells
常驻记忆T细胞
批准号：
10667482
负责人：
DAVID MASOPUST
金额：
$60.46万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-08-19 至 2024-07-31
来源：
https://reporter.nih.gov/project-details/10667482
关键词：
AddressAdoptive Cell TransfersAllergicAnatomyAutoimmuneBackBiologyBloodCellsDataDependenceDevelopmentDiseaseEmigrationsEpigenetic ProcessEventExhibitsGoalsGrowthHomingHumanImmune responseImmunityImmunologic SurveillanceInfectionInflammatoryKnowledgeLongevityLymphocyteMaintenanceMalignant NeoplasmsMemoryMethodsModelingParabiosisPhasePlayPopulationRoleSiteT memory cellT-LymphocyteTestingTherapeuticTissuesUpdateVaccinationVaccinesdevelopmental plasticityexperimental studyinnovationlymph nodesmigrationprogramsreconstitutionresidencesecondary lymphoid organtissue resident memory T cell

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中文摘要
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英文摘要
Project Summary The goal of this proposal is to make significant advancements in our understanding of resident memory T cell (TRM) biology that will inform mechanisms of immunity and vaccination. TRM longevity and stability will be rigorously examined. Moreover, the proposal will test the hypothesis that TRM exhibit developmental plasticity and retrograde migration, giving rise to cells contained within circulating T cell populations that are significantly advantaged to reconstitute TRM-based immunity specifically at their previous site of residence. Lastly, the ontogeny and function of lymph node TRM will be defined.
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  • 项目类别：
  • 资助金额：
    $60.46万
  • 财政年份：
    2020
  • 负责人：
    DAVID MASOPUST
  • 依托单位：
    UNIVERSITY OF MINNESOTA
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  • 项目类别：
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    2020
  • 负责人：
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  • 依托单位：
    UNIVERSITY OF MINNESOTA
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  • 依托单位：
    UNIVERSITY OF MINNESOTA
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  • 负责人：
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  • 依托单位：
    UNIVERSITY OF MINNESOTA