Resident Memory T Cells

常驻记忆T细胞

• 批准号: 10242062
• 负责人: DAVID MASOPUST
• 金额: $ 60.46万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-19 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242062
• 关键词: Address; Adoptive Cell Transfers; Allergic; Anatomy; Autoimmune; Back; Biology; Blood; Cells; Data; Dependence; Development; Disease; Epigenetic Process; Event; Exhibits; Goals; Growth; Homing; Human; Immune response; Immunity; Immunologic Surveillance; Infection; Inflammatory; Knowledge; Longevity; Lymphocyte; Maintenance; Malignant Neoplasms; Memory; Methods; Modeling; Parabiosis; Phase; Play; Population; Role; Site; T memory cell; T-Lymphocyte; Testing; Therapeutic; Tissues; Update; Vaccination; Vaccines; base; developmental plasticity; experimental study; innovation; lymph nodes; migration; programs; reconstitution; residence; secondary lymphoid organ

Project Summary The goal of this proposal is to make significant advancements in our understanding of resident memory T cell (TRM) biology that will inform mechanisms of immunity and vaccination. TRM longevity and stability will be rigorously examined. Moreover, the proposal will test the hypothesis that TRM exhibit developmental plasticity and retrograde migration, giving rise to cells contained within circulating T cell populations that are significantly advantaged to reconstitute TRM-based immunity specifically at their previous site of residence. Lastly, the ontogeny and function of lymph node TRM will be defined.

项目摘要 该提案的目标是在我们对驻留记忆T细胞的理解方面取得重大进展 (TRM)生物学将告知免疫和疫苗接种机制。TRM的寿命和稳定性将 严格审查。此外，该提案将检验TRM具有发育可塑性的假设 和逆行迁移，引起循环T细胞群中所含的细胞显著减少， 特别是在他们以前的居住地重建基于TRM的免疫力。最后 将定义淋巴结TRM的个体发育和功能。