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Microbiome Research Core

微生物组研究核心

基本信息

批准号：
10455078
负责人：
Brandon Briggs
金额：
$ 18.13万
依托单位：
UNIVERSITY OF ALASKA FAIRBANKS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-16 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10455078
关键词：
Active Learning Alaska Algorithms American Anaerobic Bacteria Awareness Basic Science Bioinformatics Bioreactors Cells Centers of Research Excellence Clinical Collaborations Computer software Computers Consultations Cytolysis Data Analyses Discipline Ecology Elements Ensure Equipment Equipment and Supplies Event Experimental Designs Faculty General Population Genome Goals Health Hibernation Incubators Infrastructure Laboratory culture Lead Link Metabolic Metabolic Pathway Metabolism Microbe Microbiology Molecular Molecular Analysis Nutrient Phase Play Procedures Process Research Research Personnel Research Project Grants Research Support Research Training Resources Role Services Societies Students Symbiosis System Taxonomy Technology Training Translational Research Universities base bioinformatics tool computerized data processing host microbiome microbial microbial community microbiome microbiome research nanopore novel outreach programs research data dissemination sample collection symposium tool

项目摘要

Project Summary - Microbiome Core Characterization of microbial communities and isolates is a key element necessary to achieve the scientific objectives of the proposed Center in Transformative Research in Metabolism. The Microbiome Core will provide a unique service dedicated to microbiome research and training. The goal of the Core is to support a comprehensive pipeline for characterization of microbial communities and isolates, which when characterized will generate testable hypotheses explaining host-microbiome symbiosis. We will achieve this goal by accomplishing the following Specific Aims (SA). SA1. Provide and maintain state-of-the-art technologies and procedures for a high throughput pipeline that characterizes microbial communities and isolates. SA2. Provide expertise in microbiome research, from experimental design and sample collection to data analysis and bioinformatics. SA3. Support and grow microbiome research and dissemination through expert consultation, and by engaging in outreach events with COBRE investigators and the general public. The novelty of this proposed core is to combine multiple modules that researchers can plug into at any point along the pipeline or access the full pipeline to characterize either isolates or microbial communities. The Microbiome Core is an essential component of the Research Projects supported by the Phase 1 center that focus on basic research into microbe-host symbiosis in metabolism. The Core provides the expertise, equipment, and software required for organismal, molecular, and bioinformatic analysis. Key equipment maintained by the Core includes a microbial bioreactor that allows users to set up experimental conditions similar to host guts and perturb the system to identify key microbial processes. An Illumina MiSeq and Nanopore MinION will provide the sequencing power to analyze the molecular underpinnings. In collaboration with the INBRE Bioinformatics Core, the Microbiome Core will provide expertise on bioinformatic algorithms needed for microbiome research.

项目总结-微生物组核心