Administrative Core

项目摘要-行政核心 行政核心将提供必要的监督，首先建立中心的转型 在COBRE第一阶段，阿拉斯加大学进行代谢研究，然后将确保长期 通过所有三个COBRE阶段及以后的中心的可持续性。行政领导 核心有两种形式：行政型和科学型。中心主任凯利·德鲁博士将领导行政工作。 件.科学领导和专业咨询由外部咨询委员会分享 成员，翻译咨询委员会成员，总统的教授和NIH资助的 顾问/合作者。德鲁博士是全国公认的冬眠和新陈代谢研究的领导者， C-TRiM的科学重点，并拥有丰富的行政和指导经验。外部 咨询委员会将协助德鲁博士在C-TRiM相关的监督决策，并指导教师 发展计划，这将提高研究者的能力，以竞争补充NIH个人 研究赠款或其他同等的校外支持，并确保C-TRiM作为一个主题的寿命， 多学科的，最先进的新陈代谢研究中心COBRE第一阶段的短期目标 是通过对中心实施行政监督，为实现长远目标奠定基础， 执行C-TRiM项目领导人的教师发展计划，建立生产力和效率 核心设施，监督试点项目计划，以种子在中心的初级教师的成长， 对进展情况进行严格评估。为了实现C-TRiM的长期和短期目标， 中央领导层将在行政核心中追求以下具体目标：SA 1。创造一个有利 为基础和转化科学家的培训和咨询提供环境。SA 2.建立两个新的技术 核心，以支持该中心的科学目标。SA 3.定义基础科学研究的转化路径 哺乳动物冬眠SA 4.管理和实施试点项目。完成C-TRiM后 将成为美国第一个采用冬眠作为自然适应模型的生物医学研究中心， 代谢作为一种方法来解决复杂的临床问题，在治疗代谢性疾病。

Project Summary -Administrative Core The Administrative Core will provide the oversight necessary to first establish the Center in Transformative Research in Metabolism at the University of Alaska during COBRE Phase I and then will ensure the long-term sustainability of the center through all three COBRE Phases and beyond. Leadership of the Administrative Core takes two forms: administrative and scientific. The Center Director, Dr. Kelly Drew, will lead administrative components. Scientific leadership and professional advising is shared by the External Advisory Committee members, the Translational Advisory Committee members, President's Professors and NIH-funded advisors/collaborators. Dr. Drew is a nationally recognized leader in the study of hibernation and metabolism, the scientific focus of the C-TRiM and has extensive administrative and mentoring experience. The External Advisory Committee will assist Dr. Drew in C-TRiM-related oversight decisions and guide the Faculty Development Plans that will enhance the ability of investigators to compete for complementary NIH individual research grants or other equivalent extramural support, and ensure the longevity of the C-TRiM as a thematic, multi-disciplinary, state-of-the-art research center in metabolism. The short- term goal for the Phase I COBRE is to lay the foundation for achieving the long-term goal by implementing administrative oversight of the center, executing the Faculty Development Plans for the C-TRiM Project Leaders, establishing productive and efficient Core Facilities, overseeing a Pilot Project Program to seed the growth of junior faculty in the center and providing critical evaluation of progress. To achieve the long-term and short-term goals of the C-TRiM, the center leadership will pursue the following Specific Aims in the Administrative Core: SA1. Create a supportive environment for the training and advising of basic and translational scientists. SA2. Establish two new technical cores to support scientific goals of the Center. SA3. Define translational paths for basic science research in mammalian hibernation SA4. Manage and administer the Pilot Project program. When complete the C-TRiM will be the first biomedical research center in the US to adopt hibernation as a model of natural adaptations in metabolism as an approach to solve complex clinical problems in the treatment of metabolic disease.