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Mammalian Hibernation Research- A Path Towards a Center for Transformative Research in Metabolism

哺乳动物冬眠研究——通往代谢转化研究中心的道路

基本信息

批准号：
10659060
负责人：
KELLY L DREW
金额：
$ 230.76万
依托单位：
UNIVERSITY OF ALASKA FAIRBANKS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-16 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10659060
关键词：
Address Adopted Adult Alaska Animals Arctic Regions Arousal Basal metabolic rate Basic Science Biology Biomedical Research Black Bear Body Composition Body Temperature Cardiovascular Diseases Centers of Research Excellence Cessation of life Clinical Clinical Research Clinical Trials Complex Desire for food Diet Eating Elderly Essential Amino Acids Fasting Foundations Funding Genetic Goals Health Health Care Costs Heart Arrest Hibernation Homeostasis Hospitalization Hour Human Immobilization Impairment Individual Interdisciplinary Study Knowledge Laboratories Leadership Learning Legal patent Life Link Mammals Metabolic Metabolic Diseases Metabolism MicroRNAs Modeling Muscular Atrophy Non-Insulin-Dependent Diabetes Mellitus Obesity Patients Phase Phase 0 Study Physiological Pilot Projects Population Post-Transcriptional Regulation Pre-Clinical Model Prophylactic treatment Protein Biosynthesis Regulation Research Research Infrastructure Research Personnel Research Project Grants Research Support Risk Reduction Scientist Seasons Seizures Skeletal Muscle Source Spermophilus Stroke Temperature Time Transcript Translating Translations United States National Institutes of Health Universities arctic ground squirrel career career development clinical translation design differential expression disability risk druggable target experience flexibility gut microbiota improved indexing insight interest metabolic rate microbial multidisciplinary muscle form muscle strength obese person organizational structure preservation research and development response sarcopenia skeletal muscle growth skeletal muscle metabolism skeletal preservation

项目摘要

Project Summary - Overall This application is in response to PAR-16-415, Centers of Biomedical Research Excellence (COBRE) (P20). The proposed phase 1 center (P1C) is built on a strong foundation and long-term commitment to hibernation research at the University of Alaska's Institute of Arctic Biology (IAB). The objective of the P1C is to use the expertise at IAB, in particular that of Dr. Kelly Drew, the PI, to build and strengthen the University of Alaska's hibernation research infrastructure. The plan involves guiding the career development of three investigators, experienced in research, but who have yet to receive R01s from NIH, and to guide the career development of new investigators currently showing an interest in hibernation research. The long-term goal, likely beyond the life of the P1C, is to apply what is learned about the mechanisms underlying the physiological changes in hibernation to as yet unresolved issues relevant to metabolism and metabolic diseases such as disuse muscle atrophy, sarcopenia, obesity, type 2 diabetes and cardiovascular diseases in humans. The center will support the research and career development of both experienced scientists and those getting their start in research. The center will have a focus on all stages of research from basic through translational. By defining translational paths for discoveries in hibernation, the P1C will contribute to the career development of the investigators. Strong administrative and scientific leadership will accomplish the goals of this P1C through the following four Specific Aims (SA): SA1. Establish an organizational structure and research infrastructure that will support and promote a multidisciplinary framework to define mechanisms of metabolic adaptations in hibernating mammals. SA 2. Enhance the careers of P1C project PIs as well as new investigators leading pilot projects through the P1C in order to allow them to compete successfully for NIH individual research grants. SA3. Support research projects and pilot projects aimed at developing an understanding of physiological, genetic and gut microbial mechanisms in hibernation and how these mechanisms may play a role in treating disuse muscle atrophy or sarcopenia. SA 4. Support clinical research projects related to the theme of the center. Seasonal hibernators arguably display the most dramatic natural alterations in metabolism, appetite, diet, body composition and body temperature of any mammal across their annual cycle. Such extremes offer insight into regulatory mechanisms, and druggable targets that would be less obvious in traditional pre-clinical models. This P1C focuses on genetic and gut microbial mechanisms related to protein synthesis and preservation of skeletal muscle during prolonged disuse and fasting in hibernating mammals. Once completed new investigators will be equipped to identify and translate treatments to promote anabolic sensitivity and preservation of muscle mass and strength. Such discoveries have the potential to save $1 billion per year in health-care costs in the US by reducing risk for disability, hospitalization, and death in older and mobility impaired adults.

项目摘要-整体