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Bridging the Internal and External Sensory Worlds in Autism

连接自闭症患者的内部和外部感官世界

基本信息

批准号：
10455460
负责人：
Carissa J Cascio
金额：
$ 42.46万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-07 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10455460
关键词：
Animal Model Anxiety Architecture Attention Behavior Behavioral Bladder Brain Cardiac Characteristics Clinical Complex Cues Development Emotional Endocrine system Environment Esthesia Evaluation Evoked Potentials Fascia Foundations Heart Heart Rate Human Immune system Impairment Individual Interoception Knowledge Lung Maintenance Measures Mediating Motivation Motor Pain Periodicity Physiological Play Process Psychiatry Reaction Recording of previous events Research Rest Role Safety Scanning Sensory Severities Signal Transduction Skin Sleep Social Behavior Social Interaction Stimulus Stream Subgroup Symptoms System Testing Uncertainty Viscera Visceral Vision Visual Visual Cortex Work autism spectrum disorder base blood oxygen level dependent blood oxygenation level dependent response clinically relevant communication behavior comorbidity emotion regulation emotional experience emotional functioning experience heart rate variability improved indexing individuals with autism spectrum disorder insight interest multisensory neuroimaging pleasure potential biomarker relating to nervous system repetitive behavior respiratory response sensory input sensory stimulus social social communication impairment social deficits somatosensory theories visual stimulus

项目摘要

PROJECT SUMMARY Altered sensory experiences are prevalent in autism and have been implicated in not only the core behavioral characteristics of impaired social communication and repetitive behaviors, but in a range of associated comorbidities including sleep disturbances2 and anxiety24. Recent work in the sensory domain strongly suggests that the predictability, or lack thereof, of sensory stimuli heavily influences aberrant reactions and mediates relations between sensory sensitivity, anxiety, and social motivation in autism78-79. Most sensory research thus far has emphasized exteroceptive sensation—sensory signals that originate in the external environment—with less work on interoceptive sensation—sensory signals that arise from the viscera and skin to signal the brain about the physiological condition of the body6. These interoceptive cues are often the precursors of emotional experience, and thus have significant transdiagnostic clinical relevance in psychiatry. Evaluation of the emotional relevance of the external environment—within which social stimuli are embedded—requires a continuous exchange of information between exteroceptive and interoceptive processing streams. In other words, successful navigation of the social world depends on multisensory integration across the body boundary. Critically for autism, many visceral interoceptive signals tend to be very rhythmic (e.g., cardiac signals), and/or are under voluntary control (e.g., respiratory signals) and are thus far more predictable than environmental exteroceptive cues. This predictability is enhanced on average in individuals with autism, who tend to have higher heart rates and lower heart rate variability than controls. In the current project period, we found evidence for profoundly disrupted temporal integration of visceral interoceptive and exteroceptive signals, without clear evidence of disrupted interoception alone. We now propose, in this renewal, to isolate and test potential neural drivers and clinical sequelae of this disrupted integration. The proposed work will provide important new insights into the consequences of sensory processing deficits in autism that go beyond exteroceptive sensation, incorporating a sensory milieu that has high relevance for social-emotional functioning.

项目总结