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Probing form and function of memory representations in the hippocampus of memory expert birds

探索记忆专家鸟类海马体记忆表征的形式和功能

基本信息

批准号：
10641392
负责人：
Emily Lambert Mackevicius
金额：
$ 15.7万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10641392
关键词：
3-Dimensional Address Affect Alzheimer&apos s Disease Animals Area Award Behavior Behavioral Biological Biological Models Birds Brain Calcium Cells Cognition Disorders Cognitive Collaborations Computers and Advanced Instrumentation Custom Data Decision Making Disease Progression Ecology Environment Equipment Event Exhibits Faculty Family Food Goals Head Hippocampus Human Imaging Techniques Impairment Individual Knowledge Lead Learning Link Location Mammals Maps Memory Mental disorders Mentors Methods Microscope Modeling Neurons Neurosciences Pattern Persons Population Positioning Attribute Postdoctoral Fellow Property Publishing Recurrence Rewards Rodent Side Site Source Space Models Sparrows System Techniques Technology Testing Training Universities Visit Work behavioral study cognitive task computer framework design experience experimental study laboratory experiment member memory recall model organism network architecture neural neuromechanism neuroregulation predictive modeling simulation skills spatial memory spatiotemporal success tenure track

项目摘要

Project Summary/Abstract Mental disorders that affect the hippocampus disrupt people’s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors. To map cognitive behaviors to their underlying neural mechanisms, my lab will perform theoretical analyses and simulation of state-space models of cognitive behaviors, implementing these models in a recurrent network architecture with learning rules that match biological plasticity rules (Aims 3a, c). To precisely characterize memory-guided behaviors at real-world complexity, my lab will apply state-of-the-art behavioral tracking techniques in natural settings to foraging behavior of wintering birds, chickadees and sparrows (Aim 3b). As a theorist, I will actively collaborate with experimentalists, drawing on my experience recording from the brain in animals performing cognitive tasks. My postdoctoral work in the Aronov lab, at Columbia University’s Zuckerman Institute, focuses on neural activity underlying a hippocampus-dependent one-shot memory behavior, food-caching, in the model system chickadees, caching birds with extreme memory abilities. I developed new methods for recording large populations of neurons in the chickadee hippocampus while they cache and retrieve food, and methods for precisely tracking their caching behavior (Aim 1a). Probing the hippocampus at moments of caching, I found a new mode of hippocampal activity patterns (Aim 1b), which is reactivated when birds return to retrieve food (Aim 1c). To compare this one-shot mode to representations of consistent environmental features, I am reproducing, in food-caching birds, findings from rodents showing changes to place cells at consistent reward zones, and comparing this to one-shot representations of food-caching (Aim 2a). I am developing a theoretical state-space model that explains both one-shot and consistent representations in the hippocampus (Aim 2b), incorporating hippocampus-inspired neural mechanisms (Aim 2c). Here, I outline a training plan to expand my skills and experience to lead an independent lab doing a combination of theoretical and real-world behavioral studies. I will deepen my training in theoretical methods working with my co-mentor Prof. Larry Abbott, and through affiliation with the Columbia Center for Theoretical Neuroscience. My training in tracking real-world behavior will be guided by my collaborator Prof. Vladimir Pravosudov, the leading pioneer in tracking real-world chickadee behaviors, with an extended visit to his Cognitive and Behavioral Ecology Lab and field sites. For additional training designing and fabricating custom equipment, I will work with Dr. Tanya Tabachnik, who heads the Advanced Instrumentation Core at ZI. This additional training, with instrumental support from the K99/R00 award, will prepare me well, and make me a highly competitive candidate for tenure-track faculty positions.

项目概要/摘要影响海马体的精神障碍会破坏人们形成一次性记忆的能力。我的目标是领导一个独立的实验室，将海马神经元的生物学特性与执行记忆的能力联系起来引导认知行为。为了将认知行为映射到其潜在的神经机制，我的实验室将对认知行为的状态空间模型进行理论分析和模拟，实现这些循环网络架构中的模型具有与生物可塑性规则相匹配的学习规则（目标 3a、c）。为了精确描述现实世界复杂性中记忆引导行为的特征，我的实验室将应用最先进的技术自然环境中的行为跟踪技术对越冬鸟类、山雀和麻雀（目标 3b）。作为一名理论家，我将积极与实验学家合作，借鉴我的经验执行认知任务的动物的大脑记录。我在哥伦比亚大学祖克曼研究所阿罗诺夫实验室的博士后工作重点是神经网络模型系统中海马体依赖的一次性记忆行为（食物缓存）背后的活动山雀，具有极强记忆能力的鸟类。我开发了记录大数据的新方法山雀海马体储存和检索食物时的神经元群体，以及精确跟踪它们的缓存行为（目标 1a）。在缓存时刻探测海马体，我发现了一个海马活动模式的新模式（目标 1b），当鸟类返回取食物时重新激活（目标 1b） 1c).为了将这种一次性模式与一致环境特征的表示进行比较，我正在复制，在储存食物的鸟类中，啮齿类动物的研究结果表明，将细胞放置在一致的奖励区域中发生了变化，以及将此与食物缓存的一次性表示进行比较（目标 2a）。我正在开发一个理论状态空间解释海马体中一次性和一致表征的模型（目标 2b），结合了受海马体启发的神经机制（目标 2c）。在这里，我概述了一个培训计划，以扩展我的技能和经验，以领导一个独立的实验室做理论和现实世界行为研究的结合。我将深化理论方法的训练与我的合作导师 Larry Abbott 教授合作，并通过与哥伦比亚理论中心的联系神经科学。我跟踪现实世界行为的培训将由我的合作者弗拉基米尔教授指导普拉沃苏多夫（Pravosudov）是追踪现实世界山雀行为的领先先驱，他对他的认知和行为生态学实验室和现场。如需额外培训设计和制造定制设备方面，我将与 ZI 高级仪器核心负责人 Tanya Tabachnik 博士合作。这额外的培训，以及 K99/R00 奖项的有力支持，将使我做好充分准备，并使我成为一名终身教授职位的极具竞争力的候选人。