Sensory and learning improvements elicited by oscillatory coupling through local and long-range interneurons
通过局部和远程中间神经元的振荡耦合引起感觉和学习的改善
基本信息
- 批准号:10640975
- 负责人:
- 金额:$ 20.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-15 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdvisory CommitteesAffectAnimalsAreaAssociation LearningAxonBehaviorBehavioralBrainBrain regionCa(2+)-Calmodulin Dependent Protein KinaseCalmodulinCareer MobilityCaringCellsCellular biologyColoradoCommunicationCore FacilityCouplingDataData AnalysesDevelopment PlansDevelopmental BiologyDiscriminationDiseaseDistantDrug ControlsElectrodesEnsureEnvironmentFacultyFeedbackFrequenciesFrightFundingGoalsHippocampusIndividualInterneuron functionInterneuronsKnockout MiceLeadLearningLifeLinkLong-Term DepressionLong-Term PotentiationMedialMediatingMemoryMentorsMusNeuronsNeurosciencesOdorsOlfactory LearningParvalbuminsPerformancePhasePhosphotransferasesPlayPopulationPositioning AttributePrefrontal CortexPythonsResearchResearch PersonnelResearch Project GrantsResourcesRespirationRewardsRoleSensorySignal TransductionSomatostatinTestingTrainingTraining ProgramsUniversitiesVirusWild Type MouseWorkawakecalmodulin-dependent protein kinase IIcareercareer developmentdensityexperimental studyimprovedlearned behaviormature animalmemberneural circuitneurotransmissionolfactory bulboptogeneticsresearch and developmentsenior facultysensory integrationskillssuccesssymposiumtransmission process
项目摘要
Project Summary
My long-term goal is to become a successfully funded, independent neurobiologist, conducting research aimed
at improving our understanding of learning and memory. This goal will be accomplished by the implementation
of a highly coordinated, thorough, and integrated career development plan including components of mentored
guidance and training, an adept research environment, and a complementary research project. First, a career
development plan comprised of a mentor, and co mentors, courses and conferences has been established to
provide the applicant with the skills and guidance to transition into a position of independence. The mentor, Dr.
Diego Restrepo, is a successfully funded researcher and leading expert in neuroscience and the co-mentor,
Dr. Jamie Peters, is a recognized leader in neural circuits controlling learned behaviors, primarily those
controlling drug seeking and fear in which the prefrontal cortex plays an essential role. They are well suited to
oversee my training. The mentoring team will provide critical guidance and feedback on aspects of career
development and technical components high density electrode recording with Neuropixels, data analysis, and
olfactory behavior tasks. The mentoring committee includes members at different levels of their career ranging
from young to senior faculty who will specifically assist the applicant in components directly related to career
transition. In addition, courses in MATLAB, python and conferences on neuroscience are included to facilitate
these components of the training program. Second, an adept research environment – the Department of Cell
and Developmental Biology at the University of Colorado, along with associated resources, core facilities, and
faculty members not directly involved in the applicant’s advisory committee – is established to provide
assurance of the applicant’s success. Third, a research project has been proposed to facilitate my training in
exciting new areas essential for my path to independence while simultaneously maintaining the key goals of
studying neuronal signaling networks as related to learning and memory. The research tests the important
hypothesis that altering local and long-range interneuron coupling and CaMKIIα-mediated plasticity
mediate changes in PAC that result in an increase in odor elicited change in high gamma phase
reference power and an increase in accuracy for decoding odorant identity during learning in the go-no
go task. Aim 1 will evaluate Closed loop optogenetic stimulation of local PV or SST interneurons or long-range
interneurons targeting hippocampus or mPFC in the peak or through of theta will cause coherence of
oscillatory coupling causing the mice to increase decoding accuracy. Aim 2 will evaluate transient disruption of
CaMKIIα expression in local SST interneurons or long-range interneurons targeting mPFC causes a change in
the transmission of information from the CA1 to mPFC disrupting the ability of these mice to learn to
discriminate odorants. Collectively, this comprehensive career development and research plan will ensure my
successful transition from a dependent research position into one of well-prepared independence.
项目概要
我的长期目标是成为一名成功资助的独立神经生物学家,开展旨在
提高我们对学习和记忆的理解。这一目标将通过实施来实现
高度协调、彻底和综合的职业发展计划,包括指导的组成部分
指导和培训、良好的研究环境以及互补的研究项目。首先,职业生涯
制定了由导师和共同导师、课程和会议组成的发展计划
为申请人提供过渡到独立职位的技能和指导。导师,博士。
迭戈·雷斯特雷波 (Diego Restrepo) 是一位成功资助的神经科学研究员和领先专家,也是联合导师,
Jamie Peters 博士是控制习得行为的神经回路领域公认的领导者,主要是那些
控制药物寻求和恐惧,其中前额叶皮层起着至关重要的作用。他们非常适合
监督我的训练。指导团队将为职业生涯的各个方面提供关键指导和反馈
开发和技术组件 使用 Neuropixels 进行高密度电极记录、数据分析和
嗅觉行为任务。指导委员会包括职业生涯不同级别的成员
从年轻到资深的教师,他们将在与职业直接相关的方面专门协助申请人
过渡。此外,还包括 MATLAB、Python 课程和神经科学会议,以促进
培训计划的这些组成部分。二、良好的研究环境——细胞系
科罗拉多大学发育生物学和发育生物学,以及相关资源、核心设施和
不直接参与申请人咨询委员会的教职人员 - 成立的目的是提供
申请人成功的保证。第三,提出了一个研究项目来促进我的培训
令人兴奋的新领域对于我的独立之路至关重要,同时保持以下关键目标
研究与学习和记忆相关的神经信号网络。研究测试了重要的
改变局部和远程中间神经元耦合和 CaMKIIα 介导的可塑性的假设
介导 PAC 的变化,导致气味增加,引发高伽马相变化
在 go-no 学习过程中参考功率和解码气味身份的准确性提高
去任务。目标 1 将评估局部 PV 或 SST 中间神经元或远程的闭环光遗传学刺激
中间神经元以海马体或 mPFC 为目标,在 θ 的峰值或通过时会导致
振荡耦合使小鼠提高解码精度。目标 2 将评估
CaMKIIα 在局部 SST 中间神经元或靶向 mPFC 的远程中间神经元中表达,导致
从 CA1 到 mPFC 的信息传输破坏了这些小鼠的学习能力
区分气味剂。总的来说,这个全面的职业发展和研究计划将确保我
从依赖研究职位成功过渡到准备充分的独立研究职位。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Daniel Ramirez-Gordillo', 18)}}的其他基金
Sensory and learning improvements elicited by oscillatory coupling through local and long-range interneurons
通过局部和远程中间神经元的振荡耦合引起感觉和学习的改善
- 批准号:
10505387 - 财政年份:2022
- 资助金额:
$ 20.59万 - 项目类别:
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