Center for Methodologies for Adapting and Personalizing Prevention, Treatment and Recovery Services for SUD and HIV (MAPS Center)

SUD 和 HIV 预防、治疗和康复服务调整和个性化方法中心（MAPS 中心）

• 批准号: 10640287
• 负责人: Daniel Almirall
• 金额: $ 264.42万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640287
• 关键词: Address; Adoption; Behavior; Caring; Clinic; Cocaine; Complex; Data; Data Analyses; Data Analytics; Data Collection; Development; Effectiveness; Electronic Health Record; Engineering; Ensure; Evaluation; Evidence based intervention; Experimental Designs; Generations; Grant; Guidelines; HIV; HIV Infections; Hand; Health system; Human; Incidence; Individual; International; Intervention; Mentors; Methodology; Methods; Modality; Modification; Motivation; Opioid; Outcome; Persons; Population; Positioning Attribute; Prevalence; Productivity; Recovery Support; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk; Science; Scientist; Service setting; Services; Substance Use Disorder; Testing; Theory of Change; Time; Tobacco; Training; Translations; Work; adaptive intervention; addiction; analytical method; career; combat; computer science; design; digital; digital technology; effective intervention; experience; handheld mobile device; improved; individualized prevention; innovation; interest; novel; outreach; prescription opioid; prevention service; programs; public health relevance; recovery services; recruit; support tools; synergism; theories; treatment services

PROJECT SUMMARY: OVERALL Effective prevention, treatment, and recovery services for substance use disorders (SUD) and HIV demand an increasing array of evidence-based interventions to address individuals' changing strengths, needs, and circumstances. This can be achieved via adaptive interventions, which explicitly guide how to modify the type/ intensity of services based on information about the individual. Further, advances in digital technologies, such as electronic health records (EHRs) and mobile devices, have created unprecedented opportunities to obtain data for use in adapting interventions to different levels (e.g., individual, clinic, health system), modalities (e.g., digital, in-person), and/or time scales (e.g., monthly, many times a day). However, new research methodologies are needed to realize these opportunities and inform a new generation of SUD/HIV services. The focus of the proposed Center for Methodologies for Adapting and Personalizing Prevention, Treatment, and Recovery Services for SUD and HIV (MAPS Center) is the development and dissemination of novel research methodologies that are essential to optimize adaptive interventions to combat SUD/HIV. We propose three exciting, thematically integrated research projects, each developing new methods to empirically inform the construction of adaptive SUD/HIV services. Two innovative themes — optimization (i.e., developing services that achieve the best expected outcome in a way that is not too expensive, complex, or demanding to be scalable) and adaptation (i.e., using information about context and changing needs to decide when and how to intervene) — cut across these projects, enabling our team to move SUD/HIV intervention science forward while creating enormous potential for scientific synergy. Along with the three projects, two cores — Dissemination & Training Core and Administrative Core — will enable the MAPS Center to serve as a national resource by training SUD/HIV scientists in the critical use of the methods, recruiting scientists to work on optimizing adaptive SUD/HIV services, and mentoring early career scholars. The overall Specific Aims of the MAPS Center are: (Aim A) To develop novel experimental and data analytic methods to optimize the adaptation of SUD/HIV services across different levels (e.g., individual, clinic), modalities (e.g., in-person, digital), and time scales (e.g., monthly, daily); (Aim B) To serve as a national resource by placing the innovative methods developed in the MAPS Center directly into the hands of SUD/HIV scientists; and (Aim C) To nurture and build capacity among scientists to design experiments and analyze data to inform the development of adaptive SUD/HIV services. The MAPS Center will pave the way for a new generation of highly effective and scalable interventions that will reduce the prevalence and incidence of SUD and HIV infection.

项目摘要：总体 有效的预防，治疗和恢复服务用于药物使用障碍（SUD）和HIV要求 增加一系列基于证据的干预措施，以解决个人的不断变化的优势，需求和 情况。这可以通过自适应干预措施来实现，该干预措施明确指导如何修改类型/ 服务强度基于有关个人的信息。此外，数字技术的进步，例如 作为电子健康记录（EHR）和移动设备，已经创造了前所未有的机会 用于调整干预措施到不同级别（例如个人，诊所，卫生系统）的数据（例如， 数字，面对面的）和/或时间尺度（例如，每天每天多次）。但是，新研究 需要方法来实现这些机会并为新一代的SUD/HIV服务提供信息。 拟议的改编和个性化预防，治疗，拟议方法中心的重点 SUD和HIV（地图中心）的恢复服务是新颖的发展和传播 对于优化适应性干预措施以对抗SUD/HIV至关重要的研究方法。我们建议 三个令人兴奋的，主题整合的研究项目，每个研究项目都开发了新的方法来经验告知 自适应SUD/HIV服务的建设。两个创新的主题 - 优化（即开发 以不太昂贵，复杂或要求的方式实现最佳预期结果的服务 可扩展）和适应（即使用有关上下文和变化的信息，需要决定何时以及如何决定 干预） - 削减这些项目，使我们的团队能够移动SUD/HIV干预科学前进 同时创造了科学协同作用的巨大潜力。以及三个项目，两个核心 - 传播与培训核心和行政核心 - 将使地图中心充当国家 通过培训SUD/HIV科学家在批判性使用方法中的资源，招募科学家从事 优化适应性的SUD/HIV服务以及早期的职业学者。总体具体目标 地图中心是：（目标a）开发新的实验和数据分析方法以优化 跨不同级别（例如个人，诊所）的SUD/HIV服务的适应 数字）和时间尺度（例如，每月，每天）； （目标b）通过放置 在地图中开发的创新方法将直接置于SUD/HIV科学家的手中； （目标C） 护理和建立科学家之间的能力来设计实验并分析数据以告知 开发自适应SUD/HIV服务。地图中心将为新一代高度铺平道路 有效且可扩展的干预措施将减少SUD和HIV感染的患病率和发生率。

项目成果

Hierarchical network models for exchangeable structured interaction processes.

用于可交换结构化交互过程的分层网络模型。

• DOI: 10.1080/01621459.2021.1896526
• 发表时间: 2022
• 期刊: Journal of the American Statistical Association
• 影响因子: 3.7
• 作者: Dempsey,Walter;Oselio,Brandon;Hero,Alfred
• 通讯作者: Hero,Alfred

A posterior expected value approach to decision-making in the multiphase optimization strategy for intervention science.

干预科学多阶段优化策略中决策的后验期望值方法。

• DOI: 10.1037/met0000569
• 发表时间: 2023
• 期刊: Psychological methods
• 影响因子: 7
• 作者: Strayhorn,JillianC;Collins,LindaM;Vanness,DavidJ
• 通讯作者: Vanness,DavidJ

Behavior change versus stability during the college-to-work transition: Life course and the "stickiness" of alcohol misuse at career entry.

从大学到工作的过渡期间的行为变化与稳定性：生命历程和职业进入时酗酒的“粘性”。

• DOI: 10.1111/peps.12519
• 发表时间: 2023
• 期刊: Personnel psychology
• 影响因子: 5.5
• 作者: Liu,Songqi;Bamberger,Peter;Wang,Mo;Nahum-Shani,Inbal;Larimer,Mary;Bacharach,SamuelB
• 通讯作者: Bacharach,SamuelB

Effectiveness of gamified team competition as mHealth intervention for medical interns: a cluster micro-randomized trial.

• DOI: 10.1038/s41746-022-00746-y
• 发表时间: 2023-01-11
• 期刊: NPJ digital medicine
• 影响因子: 15.2

Mediation of meaningful outcomes in early intervention: a commentary on Carruthers et al. (2023).

早期干预中有意义的结果的调解：Carruthers 等人的评论。

• DOI: 10.1111/jcpp.13913
• 发表时间: 2024
• 期刊: Journal of child psychology and psychiatry, and allied disciplines
• 作者: Shire,Stephanie;Shih,Wendy
• 通讯作者: Shih,Wendy