Center for Methodologies for Adapting and Personalizing Prevention, Treatment and Recovery Services for SUD and HIV (MAPS Center)

项目总结：总体 对物质使用障碍(SUD)和艾滋病毒的有效预防、治疗和康复服务 越来越多的基于证据的干预措施，以满足个人不断变化的优势、需求和 情况。这可以通过自适应干预来实现，它明确地指导如何修改type/ 基于个人信息的服务强度。此外，数字技术的进步，如 随着电子健康记录(EHR)和移动设备的出现，创造了前所未有的机会 用于使干预适应不同级别(例如，个人、诊所、卫生系统)、模式(例如， 数字、面对面)和/或时间尺度(例如，每月、一天多次)。然而，新的研究 需要各种方法来实现这些机会，并为新一代SUD/艾滋病毒服务提供信息。 拟议的预防、治疗和个性化方法中心的重点是 和恢复服务的SUD和艾滋病毒(MAPS中心)是开发和传播的新 研究方法对于优化抗击SUD/艾滋病毒的适应性干预措施至关重要。我们建议 三个令人兴奋的、主题集成的研究项目，每个项目都开发了新的方法来实证地提供信息 建设适应性SUD/HIV服务。两个创新主题--优化(即发展 以不太昂贵、不太复杂或要求不太高的方式实现最佳预期结果的服务 可伸缩性)和适应性(即，使用有关环境和变化的信息来确定时间和方式 干预)-跨越这些项目，使我们的团队能够推动SUD/HIV干预科学向前发展 同时为科学协同创造了巨大的潜力。除了这三个项目，还有两个核心- 传播与培训核心和行政核心--将使地图中心成为国家 通过培训SUD/HIV科学家在关键方法方面的使用，招募科学家从事以下工作 优化适应性SUD/艾滋病毒服务，并指导早期职业学者。该计划的总体具体目标 地图中心：(目标A)开发新的实验和数据分析方法，以优化 跨不同级别(例如，个人、诊所)、模式(例如，面对面， 数字)和时间尺度(例如，每月、每日)；(目标B)作为国家资源，将 在MAP中心开发的创新方法直接提供给SUD/艾滋病毒科学家；以及(目标C) 培养和建设科学家设计实验和分析数据的能力，以便为 开发适应性SUD/艾滋病毒服务。地图中心将为新一代高度 有效和可扩展的干预措施，将降低严重急性呼吸综合征和艾滋病毒感染的患病率和发病率。

PROJECT SUMMARY: OVERALL Effective prevention, treatment, and recovery services for substance use disorders (SUD) and HIV demand an increasing array of evidence-based interventions to address individuals' changing strengths, needs, and circumstances. This can be achieved via adaptive interventions, which explicitly guide how to modify the type/ intensity of services based on information about the individual. Further, advances in digital technologies, such as electronic health records (EHRs) and mobile devices, have created unprecedented opportunities to obtain data for use in adapting interventions to different levels (e.g., individual, clinic, health system), modalities (e.g., digital, in-person), and/or time scales (e.g., monthly, many times a day). However, new research methodologies are needed to realize these opportunities and inform a new generation of SUD/HIV services. The focus of the proposed Center for Methodologies for Adapting and Personalizing Prevention, Treatment, and Recovery Services for SUD and HIV (MAPS Center) is the development and dissemination of novel research methodologies that are essential to optimize adaptive interventions to combat SUD/HIV. We propose three exciting, thematically integrated research projects, each developing new methods to empirically inform the construction of adaptive SUD/HIV services. Two innovative themes — optimization (i.e., developing services that achieve the best expected outcome in a way that is not too expensive, complex, or demanding to be scalable) and adaptation (i.e., using information about context and changing needs to decide when and how to intervene) — cut across these projects, enabling our team to move SUD/HIV intervention science forward while creating enormous potential for scientific synergy. Along with the three projects, two cores — Dissemination & Training Core and Administrative Core — will enable the MAPS Center to serve as a national resource by training SUD/HIV scientists in the critical use of the methods, recruiting scientists to work on optimizing adaptive SUD/HIV services, and mentoring early career scholars. The overall Specific Aims of the MAPS Center are: (Aim A) To develop novel experimental and data analytic methods to optimize the adaptation of SUD/HIV services across different levels (e.g., individual, clinic), modalities (e.g., in-person, digital), and time scales (e.g., monthly, daily); (Aim B) To serve as a national resource by placing the innovative methods developed in the MAPS Center directly into the hands of SUD/HIV scientists; and (Aim C) To nurture and build capacity among scientists to design experiments and analyze data to inform the development of adaptive SUD/HIV services. The MAPS Center will pave the way for a new generation of highly effective and scalable interventions that will reduce the prevalence and incidence of SUD and HIV infection.