Validating MXene Electrodes for Next-Generation Electroencephalography

验证下一代脑电图的 MXene 电极

基本信息

  • 批准号:
    10640850
  • 负责人:
  • 金额:
    $ 41.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-01 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT ABSTRACT Electroencephalography (EEG) is an essential clinical diagnostic and research tool in neurology, neurorehabilitation, cognitive, and behavioral neuroscience. However, in more than 100 years of EEG research, the fundamental EEG technology has remained primitive and game-changing technological innovations have been few and far between. Most current EEG systems rely on gelled silver/silver- chloride or metal electrodes affixed on the scalp with conductive gels or pastes. These devices suffer from the large size of the electrodes, cost, risk of corrosion, preparation, and cleaning. In addition, gels and pastes are necessary to achieve adequate impedance and signal quality, but can be irritating to the skin and dry out over time. Dry (i.e., gel-free) EEG systems can bypass some of the issues of these wet EEG devices, but are still critically limited in terms of subject comfort and signal quality. Finally, MRI-compatible EEG systems for multimodal brain mapping are often highly specialized and expensive. Here, we propose to validate a fully novel, dry EEG system based on MXene materials. MXenes offer high biocompatibility, stability, conductivity, flexibility and low electrochemical impedance. In addition, they can be processed at a low cost, easily integrated into functional neural devices with a variety of geometries and shapes, record brain electrical activity with high fidelity without the need for gels or pastes, and interact weakly with magnetic fields. These properties make MXene ideal to serve as enabling material for the next-generation EEG technologies. In this proposal, we will build on promising pilot data to scale-up and optimize the fabrication and design of MXene EEG electrodes. Specifically, we will aim to outperform the electrodes used in our pilot studies while maintaining fast, cost-effective, and reliable fabrication. Then, we will validate the performance of the best performing MXene electrodes on well-established behavioral tasks associated with readily identifiable EEG spectral characteristics. Finally, we will examine the MRI compatibility of a customized multichannel MXene EEG system for simultaneous EEG/MRI mapping using quantitative and clinician ratings of signal quality, an essential step to propel its widespread adoption in brain research and clinical contexts. By completing this project, we expect to move the field forward by generating a novel dry EEG technology with superior resolution, signal fidelity, and usability compared to current tools. These advantages could pave the way for fundamental innovations in a number of domains including clinical neurology, rehabilitation, and cognitive neuroscience.
项目摘要

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Latest advances on MXenes in biomedical research and health care.
  • DOI:
    10.1557/s43577-023-00480-0
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Garg, Raghav;Vitale, Flavia
  • 通讯作者:
    Vitale, Flavia
EEG Phase Can Be Predicted with Similar Accuracy across Cognitive States after Accounting for Power and Signal-to-Noise Ratio.
考虑功率和信噪比后,可以在不同认知状态下以相似的精度预测脑电图相位。
  • DOI:
    10.1523/eneuro.0050-23.2023
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Kim,Brian;Erickson,BrianA;Fernandez-Nunez,Guadalupe;Rich,Ryan;Mentzelopoulos,Georgios;Vitale,Flavia;Medaglia,JohnD
  • 通讯作者:
    Medaglia,JohnD
Photothermal Excitation of Neurons Using MXene: Cellular Stress and Phototoxicity Evaluation.
使用 MXene 对神经元进行光热激发:细胞应激和光毒性评估。
  • DOI:
    10.1002/adhm.202302330
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    10
  • 作者:
    Wang,Yingqiao;Hartung,JaneE;Goad,Adam;Preisegger,MatíasA;Chacon,Benjamin;Gold,MichaelS;Gogotsi,Yury;Cohen-Karni,Tzahi
  • 通讯作者:
    Cohen-Karni,Tzahi
MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation.
  • DOI:
    10.1126/scitranslmed.abf8629
  • 发表时间:
    2021-09-22
  • 期刊:
  • 影响因子:
    17.1
  • 作者:
    Driscoll N;Erickson B;Murphy BB;Richardson AG;Robbins G;Apollo NV;Mentzelopoulos G;Mathis T;Hantanasirisakul K;Bagga P;Gullbrand SE;Sergison M;Reddy R;Wolf JA;Chen HI;Lucas TH;Dillingham TR;Davis KA;Gogotsi Y;Medaglia JD;Vitale F
  • 通讯作者:
    Vitale F
Emerging approaches for sensing and modulating neural activity enabled by nanocarbons and carbides.
  • DOI:
    10.1016/j.copbio.2021.10.007
  • 发表时间:
    2021-12
  • 期刊:
  • 影响因子:
    7.7
  • 作者:
    Driscoll N;Dong R;Vitale F
  • 通讯作者:
    Vitale F
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John Medaglia其他文献

John Medaglia的其他文献

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{{ truncateString('John Medaglia', 18)}}的其他基金

Validating MXene Electrodes for Next-Generation Electroencephalography
验证下一代脑电图的 MXene 电极
  • 批准号:
    10407567
  • 财政年份:
    2021
  • 资助金额:
    $ 41.68万
  • 项目类别:
Validating MXene Electrodes for Next-Generation Electroencephalography
验证下一代脑电图的 MXene 电极
  • 批准号:
    10185860
  • 财政年份:
    2021
  • 资助金额:
    $ 41.68万
  • 项目类别:
Dynamic Network Neuroscience and Control Theory: Toward Interventions for Cognitive Control Dysfunction
动态网络神经科学与控制理论:认知控制功能障碍的干预措施
  • 批准号:
    9001622
  • 财政年份:
    2015
  • 资助金额:
    $ 41.68万
  • 项目类别:
Dynamic Network Neuroscience and Control Theory: Toward Interventions for Cognitive Control Dysfunction
动态网络神经科学与控制理论:认知控制功能障碍的干预措施
  • 批准号:
    9604631
  • 财政年份:
    2015
  • 资助金额:
    $ 41.68万
  • 项目类别:
The Cerebellum's Contribution to Working Memory Following Traumatic Brain Injury
脑外伤后小脑对工作记忆的贡献
  • 批准号:
    8526842
  • 财政年份:
    2013
  • 资助金额:
    $ 41.68万
  • 项目类别:

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