Administrative Core

行政核心

• 批准号: 10641024
• 负责人: JEFFREY A KAYE
• 金额: $ 48.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641024
• 关键词: African American; Aged, 80 and over; Aging; Alzheimer' s Disease; Animal Welfare; Area; Behavior monitoring; Biological; Biological Assay; Biological Markers; Clinical; Clinical Research; Clinical Trials; Clinical Trials Unit; Clinical assessments; Collaborations; Communities; Community Participation; Data; Dementia; Development; Disease; Education; Education and Outreach; Elderly; Ensure; Event; Fostering; Goals; Home; Image; Individual; Infrastructure; Institution; Knowledge; Lead; Left; Link; Monitor; Oregon; Participant; Peripheral; Policies; Productivity; Research; Research Design; Resources; Role; Science; Scientist; Side; Sister; Specimen; Standardization; Structure; Technology; Testing; Time; Tissues; Training and Education; United States National Institutes of Health; Universities; Work; aging brain; brain tissue; cohort; collaborative environment; cooperative study; data management; data sharing; education research; follow-up; high standard; human subject; improved; innovation; neuroimaging; neuropathology; novel; outreach; pre-clinical; preservation; programs; quality assurance; recruit; repository; statistics

Project Summary: Administrative Core The Administrative Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to AD and related disorders; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Administrative Core provides oversight, management and quality assurance for the activities of the Center. It acts as the lead unit in strengthening and improving existing links between scientific and appropriate lay community leaders and organizations both locally and nationally. It is responsible for fostering new and innovative research relevant to brain aging and the dementias wherever and whenever possible. The Administrative Core Specific Aims are to: 1. Coordinate and integrate the individual core units and resources of the OADRC and their interactions with each other, as well as with individual scientists, clinicians, educators and the community. 2. Oversee and monitor the directions and interactions of the Center, setting relevant goals and optimizing resource utilization, guided by input from the scientific and lay communities. 3. Perform ongoing, regular review of progress. Ensure each unit within the OADRC performs to standards of highest quality and productivity while operating in strict compliance with human subjects, animal welfare, scientific integrity, and financial policy requirements of the university and NIH. 4. Provide a structure and forum to foster and develop new and innovative research in brain aging and the dementias, including the OADRC Developmental Projects. 5. Facilitate collaborative research, scientific interactions, and data sharing transfer with other Alzheimer’s Disease Research Centers, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Cooperative Study Unit, the Alzheimer’s Clinical Trials Consortium, the National Centralized Repository for Alzheimer’s Disease and other relevant outside research groups.

项目摘要：行政核心 行政核心是为了支持OADRC的5个总体目标的总体具体目标：1） 促进和维持AD和相关痴呆症（ADRD）的创新研究和发现， 组织基础设施支持丰富的协作环境; 2）将资源集中于特定的 重点领域：临床前痴呆和疾病活动，强调最古老的老年人; 通过外周生物标志物、神经影像学和连续居家研究捕获有意义的变化 行为监测;脑老化和老年痴呆症的神经病理学;新疗法的新测试; 改善有关痴呆症的教育和知识; 3）通过以下方式提供支持科学的材料： 特征鲜明的研究参与者、生物标本、脑组织、数据提供和分析; 4） 促进与AD和相关疾病相关的国家研究共享;以及5）提供场地， 教育和培训新科学家的机制，以及教育和告知主要利益攸关方。 OADRC的行政核心为以下活动提供监督、管理和质量保证： 中心。它是加强和改善科学和技术之间现有联系的牵头单位， 地方和全国适当的非专业社区领导人和组织。它负责培养 在任何可能的地方和任何可能的时候，开展与大脑老化和痴呆症有关的新的和创新的研究。的 行政核心具体目标是： 1.协调和整合OADRC的各个核心单位和资源及其与 相互之间，以及与个别科学家，临床医生，教育工作者和社区。 2.监督和监控中心的方向和互动，设定相关目标并优化 资源利用，由科学界和非专业界的投入指导。 3.对进展进行持续、定期的审查。确保OADRC内的每个单位都符合以下标准： 最高的质量和生产力，同时严格遵守人类受试者，动物福利， 科学诚信，以及大学和NIH的财务政策要求。 4.提供一个结构和论坛，以促进和发展新的和创新的研究，在脑老化和 痴呆症，包括OADRC发展项目。 5.促进与其他阿尔茨海默病患者的合作研究，科学互动和数据共享传输 疾病研究中心，国家阿尔茨海默病协调中心，阿尔茨海默病 合作研究单位，阿尔茨海默氏症临床试验联盟，国家集中储存库 阿尔茨海默病和其他相关的外部研究小组。