The Pacific Aging and Cancer Studies (PACS): An Infrastructure Advancing the Use of Digital Biomarkers and Related Technologies for Research on Functional Aging and Survivorship in Cancer

太平洋老龄化与癌症研究 (PACS)：促进使用数字生物标志物和相关技术进行癌症功能性衰老和生存研究的基础设施

• 批准号: 10648477
• 负责人: JEFFREY A KAYE
• 金额: $ 17.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-04 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648477
• 关键词: Acceleration; Accelerometer; Address; Age; Age Years; Aging; Biology; Biometry; Cancer Science; Cancer Survivor; Cancer Survivorship; Caring; Characteristics; Clinical; Clinical assessments; Cognition; Communities; Complex; Data; Data Analytics; Data Collection; Dedications; Dependence; Diagnosis; Digital biomarker; Dimensions; Disease; Elderly; Electronics; Ensure; Fall prevention; Family; Functional disorder; Funding; Geroscience; Health; Healthcare Systems; Hematology; Home; Impaired cognition; Impairment; Infrastructure; Knowledge; Learning; Life; Longitudinal Studies; Malignant Neoplasms; Measures; Medical; Methodology; Methods; Monitor; Moods; Morbidity - disease rate; Oncology; Patient Outcomes Assessments; Patients; Perception; Personal Satisfaction; Persons; Phase; Phased Innovation Awards; Process; Productivity; Protocols documentation; Public Health; Quality of life; Reporting; Research; Research Infrastructure; Research Personnel; Risk; Risk Factors; Signal Transduction; Sleep disturbances; Socialization; Speed; Spouses; Surveys; Survivors; Symptoms; Technology; Time; Treatment-Related Cancer; United States National Institutes of Health; Work; aged; anticancer research; behavioral health; cancer care; cancer therapy; daily functioning; data integration; design; digital assessment; digital technology; digital tool; disability; early onset; end of life; falls; frailty; functional decline; functional disability; functional loss; infrastructure development; interdisciplinary collaboration; multidimensional data; multiple chronic conditions; normal aging; novel; older patient; protective factors; remote assessment; remote sensing; response; scale up; sensor; side effect; survivorship; technology platform; trial readiness; wearable device

PROJECT SUMMARY/ABSTRACT By for speed survivors. 2040, the proportion of cancer survivors who are over 65 years of age will rise to 73% and most will survive 5 years or longer 1 . Cancer treatment an accelerate aging and cause new impairments that ogether can the trajectory of functional losses and hasten the onset of dependence and disability among older c t The number of older cancer survivors at risk of functional declines that can lead to significant impairment and disability creates an urgent public health concern. To be characteristics address these urgent problems more must known about trajectories of functional aging and how they vary with different cancers, treatments, and host and how they interact with varying risk and protective factors.A major limitation to research in cancer and aging is the lack of ready methods to capture longitudinal and multi-dimensional trajectories of functional aging across the continuum of cancer. Recent advances across a range of digital technologies, including wearable devices, unobtrusive sensors, and passive data collection applications would provide a more nuanced and comprehensive understanding of the presentation and progression of functional aging trajectories in older cancer survivors. Dedicated research infrastructures are needed to fully realize the potential of digital technologies in aging and cancer research. NOT-CA-22-030 outlines NCI's participation in PA-20-070 Research Infrastructure Development for Interdisciplinary Aging Studies calling for R21/R33 projects that propose developing requiring or scaling up a novel research infrastructure that will advance the science of cancer and aging interdisciplinary collaborations . In direct response to these funding calls, we proposea R21/R33 project to build an infrastructure advancing the use of digital biomarkers and related technologies for research on functional aging and survivorship in cancer. We have assembled a highly productive and collaborative transdisciplinary team of investigators with expertise in cancer survivorship, geroscience and aging, digital technology, hematology-oncology, and biostatistics. For this R21/R33 phased innovation award our transdisciplinary team proposes the following two milestone-based projects: R21 project: Adapt a digital technology platform for assessing functional aging in older cancer survivors and care partners by: Aim 1) assembling a community advisory board for stakeholder input; Aim 2) conducting a mixed-methods study to learn about stakeholder utilization and perceptions on digital technologies and Aim 3) creating a trial-ready and fully remote digital assessment protocol designed to maximize stakeholder engagement and retention. R33 project: Establish the ability of digital biomarkers to detect meaningful change in multiple domains of functioning during systemic cancer treatment by: Aim 1) conducting a proof-of concept longitudinal study in older patients and their spouse care partners during systemic cancer treatment associated with functional decline and Aim 2) developing and disseminating a set of digital tools and best practices for engagement and retention of older patients with cancer and their spouse care partners in longitudinal research using digital technology.

项目 总结/摘要 通过 为 速度 幸存者 到2040年，65岁以上的癌症幸存者比例将上升到73%，大多数人将存活下来。 5年或以上1。癌症治疗会加速衰老并导致新的损伤， 功能丧失的轨迹，加速老年人依赖和残疾的发生， C t 老年癌症幸存者中有功能下降风险的人数可能会导致显着的 损伤和残疾是一个紧迫的公共卫生问题。到 被 特性 解决这些紧迫问题必须更加 了解功能性衰老的轨迹以及它们如何随不同的癌症、治疗和宿主而变化 以及它们如何与不同的风险和保护因素相互作用。 癌症和衰老是缺乏现成的方法来捕捉纵向和多维的轨迹， 功能性衰老的研究进展一系列数字技术的最新进展， 包括可穿戴设备，不显眼的传感器和被动数据收集应用程序将提供更多 对功能性衰老轨迹的呈现和进展有细致入微和全面的理解 老年癌症幸存者需要专门的研究基础设施来充分发挥数字技术的潜力。 衰老和癌症研究的技术。NOT-CA-22-030概述了NCI参与PA-20-070研究 跨学科老龄化研究的基础设施发展需要R21/R33项目， 发展中 要求 或者扩大一个新的研究基础设施， 跨学科合作。为了直接响应这些资金呼吁，我们提出了一个R21/R33项目， 建立基础设施，推进数字生物标志物和相关技术的使用， 功能性衰老和癌症存活率。我们组建了一个高效协作的 跨学科的研究人员团队，在癌症生存，老年科学和老龄化，数字 技术、血液肿瘤学和生物统计学。对于R21/R33阶段创新奖，我们 跨学科团队提出了以下两个里程碑式的项目：R21项目：适应数字化 评估老年癌症幸存者和护理伙伴功能老化的技术平台：目标1） 为利益相关者的投入组建社区咨询委员会;目标2）进行混合方法研究， 了解利益相关者对数字技术的利用和看法，以及目标3）创建一个试验就绪的 完全远程数字评估协议旨在最大限度地提高利益相关者的参与度和保留率。R33 项目：建立数字生物标志物检测多个功能领域有意义变化的能力 在全身性癌症治疗期间，通过：目的1）在老年患者中进行概念验证纵向研究 及其配偶护理伴侣在与功能下降和目标2相关的系统性癌症治疗期间） 开发和传播一套参与和留住老年人的数字化工具和最佳做法 癌症患者及其配偶护理伙伴使用数字技术进行纵向研究。