Oregon Alzheimer's Disease Research Center

项目总结：总体 俄勒冈州阿尔茨海默病研究中心(OADRC)的总体目标有两个：(1)专注于 及早发现变化，以确定支持健康脑老化和向 MCI和早期痴呆症，以及(2)促进开发有效的治疗方法来防止或限制这些转变。 为实现这些目标，组织了八个核心和一个研究教育部分，以催化和 通过以下途径支持阿尔茨海默病和相关痴呆(ADRD)的创新研究和发现 支持由领先优势组成的丰富协作环境的组织基础设施 技术和方法，多学科的科学家，授权的研究志愿者，和一个鼓舞人心的 业外人士和专业利益相关者的社区。OADC提供了必要的材料来支持 研究通过有特色的研究参与者、生物标本、脑组织、数据提供 和分析。OADRC侧重于具体的重点领域：1)临床前痴呆和 强调年龄最大的老年人的疾病；2)通过对外围设备的研究捕捉到有意义变化的标志 生物标志物、神经影像和持续的居家行为监测；3)脑老化的神经病理学 和老年痴呆症；4)新疗法的新测试；5)改善教育和分享知识 关于痴呆症。 为实现这些目标和目的，OADRC的具体目标是： 1.催化和支持阿尔茨海默病和相关疾病的创新研究和发现，通过 支持由领先优势组成的丰富协作环境的组织基础设施 技术和方法，多学科的科学家，授权的研究志愿者，和一个鼓舞人心的 业外人士和专业利益相关者的社区。 2.将中心的创新和发现基础设施集中于特定的重点领域：(1) 临床前痴呆和强调高龄老年人的疾病活动性；(2)有意义变化的标志 通过研究外周生物标记物、神经成像和持续的家庭行为而获得 监测；(3)脑老化和老年痴呆的神经病理学；(4)新治疗方法的新测试； (5)提高对痴呆症的教育和知识水平。 3.通过具有良好特点的研究参与者提供必要的材料来支持科学， 生物标本、脑组织、数据提供和分析。 4.为与阿尔茨海默病和相关疾病相关的国家共用研究做出贡献。 5.提供教育和培训新科学家的场所和机制，以及教育和培训 通知关键利益攸关方，如临床医生、患者和不同的家庭成员，以解决 痴呆症的挑战。

Project Summary: Overall The overarching goal of the Oregon Alzheimer’s Disease Research Center (OADRC) is twofold: (1) to focus on early detection of change in order to define mechanisms supporting healthy brain aging and the transition to MCI and early dementia, and (2) to facilitate developing effective therapies to prevent or limit these transitions. To achieve these objectives, eight cores and a Research Education Component are organized to catalyze and sustain innovative research and discovery in Alzheimer Disease and related dementias (ADRD) through an organizational infrastructure that supports a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. The OADC provides the necessary materials to support research through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. The OADRC focuses on specific areas of emphasis: 1) Preclinical dementia and activity of disease emphasizing the oldest old; 2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; 3) Neuropathology of brain aging and late life dementia; 4) Novel testing of novel treatments, and 5) Improving education and sharing knowledge about dementia. To attain these goals and objectives, the OADRC Specific Aims are to: 1. Catalyze and sustain innovative research and discovery in Alzheimer Disease and related disorders through an organizational infrastructure supporting a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. 2. Focus the innovation and discovery infrastructure of the center toward specific areas of emphasis: (1) Preclinical dementia and activity of disease emphasizing the oldest old; (2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; (3) Neuropathology of brain aging and late life dementia; (4) Novel testing of novel treatments; and (5) Improving education and knowledge about dementia. 3. Provide the necessary materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. 4. Contribute to the national research commons relevant to Alzheimer’s disease and related disorders. 5. Provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders such as clinicians, patients and diverse family members to address the challenges of dementia.