Oregon Alzheimer's Disease Research Center

项目概要：总体 俄勒冈州阿尔茨海默病研究中心（OADRC）的总体目标是双重的：（1）关注 早期发现变化，以确定支持健康大脑老化和向健康大脑过渡的机制。 MCI和早期痴呆，（2）促进开发有效的治疗方法，以防止或限制这些转变。 为了实现这些目标，组织了八个核心和一个研究教育组成部分，以促进和 通过一个持续的创新研究和发现阿尔茨海默病和相关痴呆症（ADRD）， 组织基础架构，支持由领先的 技术和方法，多学科科学家，授权的研究志愿者，以及受启发的 非专业和专业利益相关者社区。OADC提供必要的材料， 通过特征鲜明的研究参与者、生物标本、脑组织、数据提供进行研究 和分析。OADRC专注于强调的特定领域：1）临床前痴呆和活动， 疾病强调最古老的老年人; 2）通过外周研究捕获的有意义变化的标志物 生物标志物、神经影像学和连续的家庭行为监测; 3）脑老化的神经病理学 和晚年痴呆症; 4）新疗法的新测试，以及5）改善教育和分享知识 关于痴呆症。 为了实现这些目标，OADRC的具体目标是： 1.通过以下方式促进和维持阿尔茨海默病及相关疾病的创新研究和发现 一个组织基础设施，支持由领先的 技术和方法，多学科科学家，授权的研究志愿者，以及受启发的 非专业和专业利益相关者社区。 2.将中心的创新和发现基础设施集中在特定的重点领域：（1） 临床前痴呆和疾病的活动性，强调最年长的老年人;（2）有意义的变化的标志物 通过外周生物标志物、神经影像学和持续的家庭行为研究捕获 监测;（3）脑老化和老年痴呆症的神经病理学;（4）新疗法的新测试; （5）加强对痴呆症的教育和知识。 3.提供必要的材料，以支持科学通过良好的特点研究参与者， 生物标本、脑组织、数据提供和分析。 4.为与阿尔茨海默病和相关疾病相关的国家研究共同点做出贡献。 5.为教育和培训新科学家以及教育和 告知关键利益相关者，如临床医生、患者和不同的家庭成员， 痴呆症的挑战

Project Summary: Overall The overarching goal of the Oregon Alzheimer’s Disease Research Center (OADRC) is twofold: (1) to focus on early detection of change in order to define mechanisms supporting healthy brain aging and the transition to MCI and early dementia, and (2) to facilitate developing effective therapies to prevent or limit these transitions. To achieve these objectives, eight cores and a Research Education Component are organized to catalyze and sustain innovative research and discovery in Alzheimer Disease and related dementias (ADRD) through an organizational infrastructure that supports a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. The OADC provides the necessary materials to support research through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. The OADRC focuses on specific areas of emphasis: 1) Preclinical dementia and activity of disease emphasizing the oldest old; 2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; 3) Neuropathology of brain aging and late life dementia; 4) Novel testing of novel treatments, and 5) Improving education and sharing knowledge about dementia. To attain these goals and objectives, the OADRC Specific Aims are to: 1. Catalyze and sustain innovative research and discovery in Alzheimer Disease and related disorders through an organizational infrastructure supporting a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. 2. Focus the innovation and discovery infrastructure of the center toward specific areas of emphasis: (1) Preclinical dementia and activity of disease emphasizing the oldest old; (2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; (3) Neuropathology of brain aging and late life dementia; (4) Novel testing of novel treatments; and (5) Improving education and knowledge about dementia. 3. Provide the necessary materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. 4. Contribute to the national research commons relevant to Alzheimer’s disease and related disorders. 5. Provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders such as clinicians, patients and diverse family members to address the challenges of dementia.