Immunological Mechanisms of Disease Training Program

疾病免疫机制培训计划

• 批准号: 10640277
• 负责人: AMY S MAJOR
• 金额: $ 30.04万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-05 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10640277
• 关键词: Disease; Immunologics; Training Programs

SUMMARY The Vanderbilt University School of Medicine Immunological Mechanisms of Disease Training Program (IMDTP) will fill a much-needed gap in the training of basic immunologic mechanisms of human disease. The clinical translation of basic science immunology to benefit human health now requires the development of scientists with appreciation of both inflammation and the tissues in which it occurs. The primary focus of the IMDTP will be to provide pre- and postdoctoral trainees with the expertise necessary to make novel discoveries in basic immunology and to translate these discoveries to human disease. The IMDTP will provide trainees a skill set to address how the immune system is regulated and functions in complex tissues in human disease by integrating basic immunology and principles of pathology with a particular emphasis on chronic, inflammatory diseases, and cancer. A long-term goal of the IMDTP will be to not only train the next generation of research scientists in basic immunology, but to emphasize the importance of using acquired knowledge as a translational platform on which to develop new therapies and interventions with a high regard for responsible conduct of research and reproducibility. We plan to use an interdisciplinary training approach building upon the Vanderbilt University program in Molecular Pathology and Immunology. The training faculty has been specifically recruited from the greater Vanderbilt scientific community conducting immunology-based research of chronic inflammatory diseases and consists of twenty-six highly productive faculty with successful mentoring records. In order to also allow for the training of future mentors, three mentors are at the Assistant Professor level. All of the faculty mentors have successful histories training predoctoral and postdoctoral scientists and have primary interests in immune- and inflammatory-based mechanisms of disease. These research programs will provide highly developed, diverse, and interdisciplinary training opportunities. All trainees will acquire and expand their skills in critical thinking, oral and written communication and interrogation of the literature. These primary functions of the IMDTP will be facilitated through our bi-weekly immunology and pathology seminar series and annual research symposium. Training will include participation in courses and modules on both basic immunology and pathology of disease processes. In addition, we will provide each trainee with the necessary instruction on responsible conduct in science, rigor and reproducibility in research and information on alternative career options. Funds are requested to support three predoctoral and two postdoctoral trainees. Thoughtful mentoring of these trainees, made possible by the IMDTP, will ensure the future of translational research focused on immunologic mechanisms of disease.

摘要 范德比尔特大学医学院疾病免疫机制培训 计划(IMDTP)将填补在基本免疫机制培训方面亟需的空白 人类疾病。基础科学免疫学的临床翻译，造福人类健康 需要科学家发展对炎症和组织的了解 它就会发生。IMDTP的主要重点将是为博士后和博士后学员提供 在基础免疫学方面取得新发现所需的专业知识并将这些 人类疾病的发现。IMDTP将为学员提供一套技能，以解决如何免疫 系统在人类疾病复杂组织中的调节和功能是通过整合基础 免疫学和病理学原理，特别强调慢性炎症性疾病 疾病和癌症。IMDTP的长期目标将不仅是培训下一代 研究基础免疫学的科学家，但强调使用获得性免疫的重要性 将知识作为翻译平台，在此平台上开发新的疗法和干预措施 高度重视负责任的研究和重现性。我们计划使用一个 以范德比尔特大学分子专业为基础的跨学科培训方法 病理学和免疫学。培训教员是专门从大中华区招募的 范德比尔特科学界开展以免疫学为基础的慢性炎症研究 由26名高生产率的教师组成，他们有成功的指导记录。在……里面 为了也能培训未来的导师，助理教授有三名导师 水平。所有的教师导师都有培养博士后和博士后的成功历史。 科学家主要对基于免疫和炎症的疾病机制感兴趣。 这些研究项目将提供高度发达、多样化和跨学科的培训。 机遇。所有受训人员将获得并扩展其批判性思维的口头和书面技能 文献的传播与审问。IMDTP的这些主要职能是 通过我们每两周一次的免疫学和病理学系列研讨会和年度研究促进 研讨会。培训将包括参加基础免疫学和 疾病过程的病理学。此外，我们将为每位学员提供必要的 关于科学中负责任的行为、研究中的严谨性和重现性的指导以及关于 另类职业选择。请拨资金支持三名博士后和两名博士后 实习生。通过IMDTP对这些受训人员进行周到的指导，将确保未来 翻译研究的重点是疾病的免疫学机制。