Immunological Mechanisms of Disease Training Program

疾病免疫机制培训计划

• 批准号: 9791561
• 负责人: AMY S MAJOR
• 金额: $ 29.41万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-05 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9791561
• 关键词: Disease; Immunologics; Training Programs

SUMMARY The Vanderbilt University School of Medicine Immunological Mechanisms of Disease Training Program (IMDTP) will fill a much-needed gap in the training of basic immunologic mechanisms of human disease. The clinical translation of basic science immunology to benefit human health now requires the development of scientists with appreciation of both inflammation and the tissues in which it occurs. The primary focus of the IMDTP will be to provide pre- and postdoctoral trainees with the expertise necessary to make novel discoveries in basic immunology and to translate these discoveries to human disease. The IMDTP will provide trainees a skill set to address how the immune system is regulated and functions in complex tissues in human disease by integrating basic immunology and principles of pathology with a particular emphasis on chronic, inflammatory diseases, and cancer. A long-term goal of the IMDTP will be to not only train the next generation of research scientists in basic immunology, but to emphasize the importance of using acquired knowledge as a translational platform on which to develop new therapies and interventions with a high regard for responsible conduct of research and reproducibility. We plan to use an interdisciplinary training approach building upon the Vanderbilt University program in Molecular Pathology and Immunology. The training faculty has been specifically recruited from the greater Vanderbilt scientific community conducting immunology-based research of chronic inflammatory diseases and consists of twenty-six highly productive faculty with successful mentoring records. In order to also allow for the training of future mentors, three mentors are at the Assistant Professor level. All of the faculty mentors have successful histories training predoctoral and postdoctoral scientists and have primary interests in immune- and inflammatory-based mechanisms of disease. These research programs will provide highly developed, diverse, and interdisciplinary training opportunities. All trainees will acquire and expand their skills in critical thinking, oral and written communication and interrogation of the literature. These primary functions of the IMDTP will be facilitated through our bi-weekly immunology and pathology seminar series and annual research symposium. Training will include participation in courses and modules on both basic immunology and pathology of disease processes. In addition, we will provide each trainee with the necessary instruction on responsible conduct in science, rigor and reproducibility in research and information on alternative career options. Funds are requested to support three predoctoral and two postdoctoral trainees. Thoughtful mentoring of these trainees, made possible by the IMDTP, will ensure the future of translational research focused on immunologic mechanisms of disease.

概括 范德比尔特大学医学院免疫学疾病培训机制 计划（IMDTP）将在培训基本免疫机制的培训中填补急需的空白 人类疾病。基础科学免疫学的临床翻译现在使人类健康受益 需要对科学家的发展，并欣赏炎症和组织 它发生。 IMDTP的主要重点是向博士后学员提供 在基本免疫学上发现新颖的发现并翻译这些新颖的专业知识 发现人类疾病。 IMDTP将为受训者提供一项技能，以解决如何免疫 通过整合基本 免疫学和病理学原理，特别着重于慢性炎症 疾病和癌症。 IMDTP的长期目标不仅是训练下一代 基本免疫学的研究科学家，但要强调使用获得的重要性 知识是一种转化平台，以此来开发新的疗法和干预措施 高度重视负责任的研究和可重复性。我们计划使用 跨学科的培训方法在范德比尔特大学分子计划基础上建立 病理学和免疫学。培训教师是从更大的 范德比尔特科学界基于免疫学的慢性炎症研究 疾病和由26个高产教师组成，并具有成功的指导记录。在 为了允许对未来的导师进行培训，三位导师在助理教授 等级。所有教师的导师都有成功的历史培训培训前和博士后 科学家，对疾病的免疫和炎症机制具有主要兴趣。 这些研究计划将提供高度发达，多样化和跨学科培训 机会。所有学员将获得和扩大他们在批判性思维，口头和书面方面的技能 文学的沟通和审讯。 IMDTP的这些主要功能将是 通过我们每两周的免疫学和病理研讨会和年度研究促进 座谈会。培训将包括参加基本免疫学和模块的课程和模块 疾病过程的病理。此外，我们将为每个学员提供必要的 有关科学，严格和可重复性的负责任行为的指导，有关研究和信息的信息 替代职业选择。要求资金支持三个前肠和两个博士后 学员。 IMDTP使这些受训者成为可能的周到的指导将确保未来 转化研究的重点是疾病的免疫机制。