Novel Biofilm Inhibitors of Oral Streptococci
新型口腔链球菌生物膜抑制剂
基本信息
- 批准号:10640889
- 负责人:
- 金额:$ 13.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AbscessAdsorptionAffectAffinityAmmoniumAnimal ModelAreaBacteriaBiologicalBiological AssayCaries preventionCell SurvivalCellsCellular AssayCeriumChemical ModelsChemicalsChildChildhoodChronic DiseaseClinicalDNADentalDental CareDental EnamelDental PulpDental cariesDentinDentistryDevelopmentDiseaseElectron MicroscopyElectron energy loss spectroscopyEnzyme InhibitionEnzymesEpithelial CellsEstheticsEtiologyExhibitsExposure toFibroblastsFoundationsFutureGingivaGlucosyltransferasesGoalsGrowthHealthHepG2HepatocyteHumanHydrolysisHydroxyapatitesIn VitroInvestigationIon ExchangeLiteratureMentorsMethodologyMethodsMicrobial BiofilmsModelingNBL1 geneOralOral MedicineOxidantsPatientsPhosphoric Monoester HydrolasesPolysaccharidesPostdoctoral FellowPredispositionPreventiveProductionResearchResearch PersonnelResolutionSalivaSaltsScanningSilverSocietiesSodium ChlorideSpectrum AnalysisStainsStreptococcusStreptococcus mutansStreptococcus sobrinusStructureStudy modelsSurfaceTechniquesTestingTimeTissuesTooth LossTooth structureTopical applicationToxic effectTransmission Electron MicroscopyWorkabsorptionantimicrobialbactericidecerium oxide nanoparticleclinical applicationcost effectivedemineralizationefficacy testingextracellularhigh resolution imaginghuman tissueinhibitorintestinal epitheliumlow socioeconomic statusmacromoleculemicrobiotananoparticlenoveloral painoral streptococcipediatric patientsself esteemstandard of caretooth surfacetranslational modeltreatment choice
项目摘要
PROJECT SUMMARY/ABSTRACT
Dental caries is the most common childhood disease in today’s society. Untreated dental caries contributes to
oral pain, abscess development, tooth loss and poor esthetics affecting both the health and self-esteem of
children. Restorative dental procedures are the standard of care in the treatment of dental caries yet often are
not feasible for those children of low socioeconomic status. Long lasting preventive methods are the treatment
of choice in such patients that cannot routinely see dental professionals. The etiology of dental caries in pediatric
patients is attributed to tooth-borne biofilms comprising Streptococcus mutans and Streptococcus sobrinus. This
bacteria-based etiology has led clinicians to turn to tooth-applied, bactericidal silver (Ag) agents as a cost-
effective method to arrest dental caries. However, Ag use is associated with tooth staining, tissue toxicity and
disruption of the microbiota calling into question their repeated application and long-term use. This proposal
sets forth the first example of cerium oxide nanoparticles (CeO2-NP) as non-bactericidal biofilm inhibitors of oral
Streptococci. Preliminary results demonstrate in vitro biofilm inhibition of S. mutans and S. sobrinus by CeO2-
NP prepared by Ce(IV) ammonium salt hydrolysis. CeO2-NP prepared by the current methodology have exhibited
a higher efficacy in limiting in vitro biofilm formation as compared to AgNO3, the current standard for topical
treatment in pediatric dental caries arrest. Importantly, the mechanism of biofilm inhibition by CeO2-NP is non-
bactericidal as opposed to AgNO3. A significant challenge of tooth-applied agents is maintaining a clinically
effective concentration of the agent at the tooth surface. This proposal is unique in that it sets forth not only non-
bactericidal biofilm inhibitors for tooth application, but a method of retaining them at the enamel surface for an
extended period of time. Cerium salts have a well-known affinity for hydroxyapatite and have been shown to
limit demineralization (erosion) of the enamel surface with acidic challenge. Hydroxyapatite is a dynamic
structure that facilitates surface chemical exchange of ions and nanoparticles of varying size with simple topical
administration. Given the known affinity of Ce-agents for the enamel surface, we propose the incorporation of
the novel biofilm inhibiting CeO2-NP agents of this proposal onto the enamel surface via adsorption. The
objectives of this proposal are to investigate potential extracellular mechanisms of biofilm inhibition by CeO2-NP
as well as the chemical interaction of CeO2-NP with hydroxyapatite surfaces and its efficacy in translation model
studies.
项目总结/文摘
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Nanoceria Aggregate Formulation Promotes Buffer Stability, Cell Clustering, and Reduction of Adherent Biofilm in Streptococcus mutans.
- DOI:10.1021/acsbiomaterials.3c00174
- 发表时间:2023-07
- 期刊:
- 影响因子:5.8
- 作者:K. Ellepola;L. Bhatt;Lin Chen;Chen Han;Forough Jahanbazi;R. Klie;Francisco J. Lagunas Vargas;Yuanbing Mao;Kirill Novakovsky;Bibash Sapkota;R. Pesavento
- 通讯作者:K. Ellepola;L. Bhatt;Lin Chen;Chen Han;Forough Jahanbazi;R. Klie;Francisco J. Lagunas Vargas;Yuanbing Mao;Kirill Novakovsky;Bibash Sapkota;R. Pesavento
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