Training Program in Chemosensory Science

化学传感科学培训计划

• 批准号: 10640572
• 负责人: Daniel W Wesson
• 金额: $ 21.1万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640572
• 关键词: Science; Sensory; Training Programs

ABSTRACT The overall goal of this T32 Institutional National Research Science Award proposal is to support predoctoral training in chemical senses research through the Training Program in Chemosensory Science (TPCS) at the University of Florida. The study of the chemical senses (smell, taste, chemesthesis and internal chemosensing) has broad impacts on human health, including: the effects of smell or taste impairments (e.g., anosmia, phantom tastes, etc.) on eating, nutrition, safety, interpersonal relationships and the incidence of depression; the engagement of normal smell and taste to promote healthy eating; the contribution of maladaptive chemosensory behaviors to overconsumption and its related diseases (e.g., diabetes, hypertension, etc.); and the control of disease vectors and parasites through disruption of host seeking or reproduction. Unfortunately, chemosensory scientists with the appropriate methodological expertise and requisite knowledge in this multidisciplinary field continue to be in short supply. This need creates a strong impetus for building an integrative predoctoral training program in chemosensory science. The chemosensory research community at the University of Florida – highly diverse in research questions and methodologies, but organized and integrated through the UF Center for Smell and Taste – is uniquely positioned to lead this program.The TPCS has four Specific Aims: (1) To conduct a successful program of predoctoral training in chemosensory science composed of a didactic curriculum, a series of chemical senses research-focused discussions, a mentored research experience, a patient outreach experience, and professional development; (2) To link predoctoral trainees with strong research mentors and a multidisciplinary committee of experienced investigators; (3) To recruit talented and diverse trainees from national and local pools of eligible candidates; and (4) To evaluate the program in terms of educational objectives tailored to the pre-doctoral program. This renewal application seeks five years' funding for the TPCS to support four predoctoral students per year (two in each of two years of training support per trainee) with the aim of producing independent scientists capable of making significant contributions to the science of smell, taste and chemesthesis. At the conclusion of the period of support, a diverse group of predoctoral trainees will have been mentored and taught the advanced methods, fundamental knowledge, and multidisciplinary approaches necessary to further chemosensory research. Together, this program provides a comprehensive training in chemosensory science that will effectively prepare our trainees for the wealth of chemosensory science careers available.

摘要 这个T32机构国家研究科学奖提案的总体目标是支持博士前 通过化学传感科学培训计划（TPCS）进行化学传感研究培训， 佛罗里达大学。化学感觉（嗅觉、味觉、化学感觉和内部感觉）的研究 化学传感）对人类健康具有广泛的影响，包括：嗅觉或味觉损伤的影响（例如， 嗅觉丧失、幻味等）饮食、营养、安全、人际关系和 抑郁症;参与正常的嗅觉和味觉，以促进健康饮食;的贡献， 对过度消费及其相关疾病的不适应化学感受行为（例如，糖尿病、 高血压等）;以及通过破坏寻找寄主的过程来控制病媒和寄生虫， 生殖不幸的是，具有适当方法学专业知识和 这一多学科领域的必要知识仍然短缺。这种需要创造了一个强大的 推动建立一个综合的博士前培训计划在化学传感科学。化学感受 佛罗里达大学的研究社区-研究问题和方法高度多样化，但 组织和通过用友中心的风味和味道集成-是独特的定位，以引领这一点 计划。TPCS有四个具体目标：（1）进行博士前培训的成功计划， 化学感官科学组成的一个教学课程，一系列的化学感官研究为重点 讨论，指导研究经验，患者外展经验和专业发展;（2） 将博士前学员与强大的研究导师和经验丰富的多学科委员会联系起来 （3）从国家和地方合格候选人库中招聘有才能和多样化的受训人员; （4）根据博士预科课程的教育目标来评估该课程。这 更新申请寻求TPCS五年的资金，每年支持四名博士预科生（两名在 每名受训人员两年的培训支助），目的是培养独立科学家， 对嗅觉、味觉和化学感觉科学做出了重大贡献。在这一期间结束时 支持，一个多元化的博士前学员群体将得到指导和教授先进的方法， 基础知识和多学科的方法，需要进一步的化学传感器研究。 总之，该计划提供了一个全面的培训化学传感科学，将有效地准备 我们的学员为丰富的化学传感科学的职业生涯可用。

项目成果

TAPPing into the potential of inducible tau/APP transgenic mice.

挖掘可诱导 tau/APP 转基因小鼠的潜力。

• DOI: 10.1111/nan.12791
• 发表时间: 2022
• 期刊: Neuropathology and applied neurobiology
• 影响因子: 5
• 作者: Xu,Guilian;Ulm,BrittanyS;Howard,John;Fromholt,SusanE;Lu,Qing;Lee,BrianBenedict;Walker,Ariel;Borchelt,DavidR;Lewis,Jada
• 通讯作者: Lewis,Jada

Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts.

表达非典型嗅觉受体鸟类环酶D的感觉神经元才能通过各种社会环境中小鼠获取气味偏好。

• DOI: 10.1016/j.physbeh.2020.113150
• 发表时间: 2020-12-01
• 期刊: Physiology & behavior
• 影响因子: 2.9
• 作者: Zimmerman AD;Nagy CR;Munger SD
• 通讯作者: Munger SD

Neuron-specific cilia loss differentially alters locomotor responses to amphetamine in mice.

• DOI: 10.1002/jnr.24755
• 发表时间: 2021-03
• 期刊: Journal of neuroscience research
• 影响因子: 4.2
• 作者: Ramos C;Roberts JB;Jasso KR;Ten Eyck TW;Everett T;Pozo P;Setlow B;McIntyre JC
• 通讯作者: McIntyre JC

Olfactory subsystems associated with the necklace glomeruli in rodents.

• DOI: 10.1007/s00441-020-03388-2
• 发表时间: 2021-01
• 期刊: Cell and tissue research
• 影响因子: 3.6
• 作者: Zimmerman AD;Munger SD
• 通讯作者: Munger SD