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Translational Imaging Shared Resource

转化成像共享资源

基本信息

批准号：
10641720
负责人：
Mukund Seshadri
金额：
$ 7.68万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-06-16 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10641720
关键词：
Advisory Committees American Association of Cancer Research Animal Cancer Model Animal Disease Models Animals Award Awareness Basic Science Cancer Center Cancer Center Support Grant Committee Members Communication Comprehensive Cancer Center Consultations Data Detection Disease Doctor of Philosophy Ensure Environment Equity Evaluation Faculty Feedback Foundations Functional Imaging Funding Future Grant Image Image Analysis Imaging technology International Investigational Therapies Journals Legal patent Magnetic Resonance Imaging Malignant Neoplasms Monitor Nanotechnology Nature Needs Assessment Oncology Patients Peer Review Play Policies Positron-Emission Tomography Privatization Protocols documentation Publications Radiology Specialty Reporting Research Research Design Research Personnel Research Support Resource Sharing Resources Role Scheme Science Services Site Structure Therapeutic Time Training Translational Research Translations Tumor Biology United States National Institutes of Health Universities Update anatomic imaging anticancer research bioimaging bioluminescence imaging clinical application clinical imaging clinical translation cost effective experience fluorescence imaging image translation imaging modality improved in vivo imaging instrumentation meetings member multimodality non-invasive imaging operation optical imaging photoacoustic imaging posters pre-clinical preclinical imaging preclinical trial programs quantitative imaging research study single photon emission computed tomography technology platform theranostics translational goal ultrasound

项目摘要

The overall mission of the Translational Imaging Shared Resource (TISR) is to provide state-of-the-art preclinical and translational imaging services to investigators at Roswell Park in a time-efficient and cost- effective manner. The resource provides users access to advanced imaging modalities including magnetic resonance imaging (MRI), ultrasound (US), photoacoustic imaging (PAI), fluorescence and bioluminescence imaging (BLI). The resource is led by two PhD faculty with extensive experience in preclinical and clinical imaging, and is the only shared resource within 200 miles of Buffalo that allows for multimodal anatomic and functional imaging of small and large animal models of disease. TISR served a total of 67 Roswell users, of which 60 (90%) were CCSG members, including 46 CCSG members with peer reviewed funding and 14 CCSG members without peer reviewed funding from all five research programs who are conducting basic and translational investigations in oncology, radiology and cancer therapeutics. This has led to 4 patents and 71 peer-reviewed publications including several publications in top-tier cancer and imaging journals. In the past 5 years, TISR has provided imaging services for 41 NIH grants and 6 DoD grants. TISR was also awarded two NIH S10 shared instrumentation grants that enabled expansion of its imaging services to include state-of-the- art optical and optoacoustic imaging methods. The resource provides cancer center members 24/7 access to and training in the application of non-invasive imaging technologies for their cancer research needs. The specific aims of the TISR are to: 1) Provide Roswell Park investigators with access to state-of-the-art in vivo imaging technologies; 2) Develop customized imaging protocols and quantitative image analysis schemes to conduct preclinical trials of experimental therapeutics in small and large animal models of cancer; 3) Establish a technology platform that facilitates clinical translation of imaging methods for improved disease detection and therapy monitoring in patients. An integral part of TISR operations is the continual assessment of need for expanding and/or updating imaging technology through evaluation of current demand, feedback from existing users and anticipated future research needs of cancer center members. Future plans for TISR include upgrading the existing MRI instrumentation and expansion of imaging services to include PET/SPECT and CT.

平移成像共享资源（TISR）的总体任务是提供最先进的技术