Impact of Vitamin D on the Chemopreventive Efficacy of Erlotinib against Oral Cancer

项目摘要 新冠肺炎的爆发从根本上改变了医疗实践，导致 几乎所有医疗专业的医疗保健都发生了彻底的变化。尤其是牙科，一直以来 受这场大流行的严重影响，因为在提供牙科服务时涉及到密切的人与人之间的接触 产生气雾剂的护理和治疗程序，通常导致牙科保健专业人员 接触/接触血液、唾液和呼吸道飞沫。具体地说，大流行导致了 适应诊断和治疗模式、修改临床工作流程和牙科/口腔护理 交付模式。鉴于大流行仍在继续，这些经修改的口服药物的影响程度 卫生保健提供模式，特别是在高危患者群体(例如癌症患者)中的模式尚不清楚。这 正在提交“对现有NIH补助金的紧急竞争性修订(紧急补充)”的申请 应PA-18-935的要求，向R01DE024595(PI：Seshadri，Mukund)申请补充资金。这个 本附录中提出的研究是针对最近的冠状病毒而专门开发的 疾病2019(新冠肺炎)大流行，以评估癌症患者牙科护理服务延误的影响。 这项提议对NIDCR具有立竿见影的影响。

Project Summary The outbreak of COVID-19 has changed the practice of medicine in a fundamental manner resulting in sweeping changes in healthcare virtually across all medical specialties. Dentistry, in particular, has been dramatically affected by this pandemic, given the close `person-to-person' contact involved in delivering dental care and treatment procedures that produce aerosols and often result in the dental health care professional (DHCP) contact/exposure to blood, saliva and respiratory droplets. Specifically, the pandemic has led to adaptations to diagnostic and treatment paradigms, modifications to clinical workflow and dental/oral care delivery models. Given that the pandemic is still on-going, the magnitude of the impact of these modified oral health care delivery models, especially in high-risk patient populations (e.g. cancer patients) is not known. This application for a “Urgent Competitive Revision to Existing NIH Grants (Urgent Supplement)” is being submitted in response to PA-18-935 to request supplemental funding to the R01DE024595 (PI: Seshadri, Mukund). The research proposed in this supplement was specifically developed in response to the recent coronavirus disease 2019 (COVID-19) pandemic to assess the impact of dental care delivery delays in cancer patients. The proposal is of immediate and high impact to NIDCR.