Impact of Vitamin D on the Chemopreventive Efficacy of Erlotinib against Oral Cancer

项目摘要 COVID-19的爆发从根本上改变了医学实践， 医疗保健几乎在所有医学专业中发生了翻天覆地的变化。特别是牙科， 由于提供牙科服务涉及密切的“人对人”接触， 护理和治疗程序产生气溶胶，并经常导致牙科保健专业人员 （DHCP）接触/暴露于血液、唾液和呼吸道飞沫。具体而言，大流行病导致 适应诊断和治疗模式，修改临床工作流程和牙科/口腔护理 交付模式。鉴于大流行仍在持续，这些经修改的口服疫苗的影响程度 健康护理提供模式，特别是在高风险患者群体（例如癌症患者）中的健康护理提供模式是未知的。这 正在提交“对现有NIH赠款进行紧急竞争性修订（紧急补充）”的申请 响应PA-18-935，请求为R 01 DE 024595提供补充资金（PI：Seshadri，Mukund）。的 本增刊所建议的研究，是因应最近的冠状病毒而特别发展的。 疾病2019（COVID-19）大流行，以评估癌症患者牙科护理交付延迟的影响。 该建议对NIDCR具有直接和高度的影响。

Project Summary The outbreak of COVID-19 has changed the practice of medicine in a fundamental manner resulting in sweeping changes in healthcare virtually across all medical specialties. Dentistry, in particular, has been dramatically affected by this pandemic, given the close `person-to-person' contact involved in delivering dental care and treatment procedures that produce aerosols and often result in the dental health care professional (DHCP) contact/exposure to blood, saliva and respiratory droplets. Specifically, the pandemic has led to adaptations to diagnostic and treatment paradigms, modifications to clinical workflow and dental/oral care delivery models. Given that the pandemic is still on-going, the magnitude of the impact of these modified oral health care delivery models, especially in high-risk patient populations (e.g. cancer patients) is not known. This application for a “Urgent Competitive Revision to Existing NIH Grants (Urgent Supplement)” is being submitted in response to PA-18-935 to request supplemental funding to the R01DE024595 (PI: Seshadri, Mukund). The research proposed in this supplement was specifically developed in response to the recent coronavirus disease 2019 (COVID-19) pandemic to assess the impact of dental care delivery delays in cancer patients. The proposal is of immediate and high impact to NIDCR.