Acquisition of a 7T MR scanner for Translational Imaging Research at Roswell Park

购买一台 7T MR 扫描仪用于罗斯威尔公园的转化成像研究

• 批准号: 10176803
• 负责人: Mukund Seshadri
• 金额: $ 200万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176803
• 关键词: 20 year old; Aging; Applications Grants; Buffaloes; Comprehensive Cancer Center; Custom; Electronics; Faculty; Failure; Fee-for-Service Plans; Functional Imaging; Funding; Growth; Image; Imaging technology; Institution; Investigation; Magnetic Resonance Imaging; New York; Oncology; Radiology Specialty; Research; Research Personnel; Resource Sharing; Risk; S10 grant; Secure; Services; United States National Institutes of Health; Universities; anatomic imaging; cancer imaging; faculty research; instrument; member; molecular imaging; pre-clinical research; preclinical imaging; prevent; programs

Project Summary The purpose of this S10 grant application is to secure funding to replace a technically outdated 4.7T magnetic resonance imaging (MRI) scanner for the Translational Imaging Shared Resource (TISR) at Roswell Park Comprehensive Cancer Center. For nearly two decades, the TISR at Roswell Park has been providing customized scientific and technical preclinical imaging services on a fee for service basis to NIH funded investigators at Roswell Park, the State University of New York at Buffalo and neighboring academic institutions in Western New York. It is a heavily utilized by over 50 Roswell Park and UB faculty members who are conducting basic and translational investigations in oncology and radiology. The existing 4.7T magnet was purchased through a combination of institutional and state funds and was the first MR scanner installed in WNY dedicated for preclinical research. Since 2001, TISR has catered to the imaging needs of 168 users, out of whom 105 utilized the existing 4.7T MR scanner. However, this aging instrument has encountered two soft quenches in the last 10 years, and has outdated electronics that lack upgrading capabilities. These limitations pose a significant risk to faculty and research programs at the only NCI designated Comprehensive Cancer Center in the state of New York outside of Manhattan. Another technical failure of the present ~20-year-old MR scanner would be catastrophic and seriously jeopardize the conduct of active NIH/NCI funded research at Roswell Park and prevent our faculty from pursuing new projects utilizing MRI for anatomic, functional and molecular imaging of cancer. Acquisition of an upgraded instrument is therefore a critical need that will not only enable TISR to meet the existing demand for this imaging technology but also facilitate further growth of TISR.

项目摘要 此S10补助金申请的目的是确保资金，以取代技术上过时的4.7T磁 Roswell Park平移成像共享资源（TISR）的共振成像（MRI）扫描仪 综合癌症中心。近二十年来，罗斯韦尔公园的TISR一直在提供 定制的科学和技术临床前成像服务，以服务收费为基础，由NIH资助 罗斯韦尔公园，布法罗的纽约州立大学和邻近学术机构的调查人员 纽约西部的机构。这是一个大量使用超过50罗斯韦尔公园和UB教师谁 正在进行肿瘤学和放射学的基础和转化研究。现有的4.7T磁铁 通过机构和国家基金的组合购买，是第一台安装在 WNY致力于临床前研究。自2001年以来，TISR已经满足了168名用户的成像需求， 其中105例使用现有的4.7T MR扫描仪。然而，这种老化的仪器遇到了两个软 在过去的10年里淬火，并有过时的电子产品，缺乏升级能力。这些限制 对NCI唯一指定的综合癌症的教师和研究计划构成重大风险 位于曼哈顿外的纽约中心。当前~20岁MR的另一个技术故障 扫描仪将是灾难性的，并严重危及NIH/NCI资助的研究的进行 罗斯韦尔公园和防止我们的教师追求新的项目利用MRI的解剖，功能和 癌症的分子成像因此，购置升级仪器是一项关键需求， 使TISR能够满足对这种成像技术的现有需求，但也促进了TISR的进一步发展。