Shape Memory Polymer Foams for Hemorrhage Control in Traumatic Wounds

用于控制外伤出血的形状记忆聚合物泡沫

• 批准号: 10638377
• 负责人: Michaela Christina Kollisch-Singule
• 金额: $ 18.73万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10638377
• 关键词: Address; Affect; Aftercare; Analgesics; Animals; Architecture; Biocompatible Materials; Blood; Body Temperature; Cellulose; Cessation of life; Chitosan; Clinical; Coagulation Process; Data; Device Designs; Devices; Dryness; European Union; Excision; Exposure to; Family suidae; Fibrin; Focal Infection; Future; Future Generations; Goals; Gunshot wound; Heating; Hemorrhage; Hemostatic Agents; Hemostatic function; High temperature of physical object; Hospitals; Hour; Human; In Vitro; Injury; Japan; Limb structure; Liver; Memory; Mission; Modeling; Monitor; Outcome; Patients; Peripheral Vascular Diseases; Polymers; Porosity; Property; Public Health; Research; Safety; Shapes; Site; Sterile coverings; System; Techniques; Time; Tissues; Tourniquets; Training; Trauma; United States; United States Food and Drug Administration; United States National Institutes of Health; Water; Work; Wound models; antimicrobial; biomaterial compatibility; clinical translation; clinically relevant; combat; design; expectation; femoral artery; implantation; improved; improved outcome; in vivo; infection risk; liver injury; pre-clinical; pressure; remote location; survival outcome; traumatic wound; wound

PROJECT SUMMARY/ABSTRACT Uncontrolled hemorrhage is the primary cause of trauma-related death, and approximately half of hemorrhage deaths occur before the patient reaches the hospital. Current techniques for hemorrhage control are insufficient for a large number of wounds and do not adequately address non-compressible hemorrhages. Thus, there is a critical need for improved hemostatic dressing materials that are inexpensive, easy to apply, effective, and safe to use over prolonged time frames. In the absence of such treatment options, tragic deaths from uncontrolled bleeding will continue. The long-term goal of the proposed work is to provide an accessible option for hemorrhage control that can be used with minimal training in remote situations. The overall objectives in this application are to characterize efficacy of a promising biomaterial platform, shape memory polymer (SMP) foams, in clinically-relevant hemorrhage models and to develop easy-to-use storage and delivery devices. In preliminary work in a porcine grade V liver injury, SMP foam treatment provided faster hemostasis, reduced total blood loss, and improved survival relative to treatment with clinical controls. The rationale for the proposed work is that future clinical translation efforts will be enabled by an improved understanding of how foam properties affect hemorrhage control and expanded pre-clinical characterization of this promising platform. To achieve these objectives, the following specific aims will be pursued: Specific Aim 1: Evaluate effects of SMP foam architectures on hemorrhage control in in vitro wound models, and design storage and delivery devices for non-compressible torso wounds and compressible extremity wounds. Specific Aim 2: Characterize SMP foam efficacy in vivo in a non-compressible grade V liver injury. Specific Aim 3: Characterize SMP foam application, efficacy, removal, and safety in vivo in a compressible femoral artery injury. At the completion of these studies, the expectation is to have clinically-relevant SMP foam- based hemostatic device designs for use in compressible and non-compressible traumatic wounds. The primary positive impact of these studies will be a hemostatic dressing that is easy- to-use and effective in a range of hemorrhagic wound types.

项目摘要/摘要 不受控制的出血是创伤相关死亡的主要原因， 一半的出血死亡发生在病人到达医院之前。的当前技术 出血控制对于大量伤口是不够的， 不可压缩的泡沫。因此，迫切需要改进的止血敷料 材料便宜，易于应用，有效，长时间使用安全 跳转如果没有这样的治疗方案，不受控制的出血造成的悲惨死亡将 继续 拟议工作的长期目标是为出血提供一个可访问的选择 在远程情况下，只需经过最少的培训即可使用。这方面的总体目标 应用是表征一种有前途的生物材料平台，形状记忆 聚合物（SMP）泡沫，在临床相关的出血模型，并开发易于使用 存储和输送装置。在猪V级肝损伤的初步工作中，SMP泡沫 治疗提供了更快的止血，减少总失血量，并提高生存率， 临床对照治疗。拟议工作的理由是，未来的临床 通过更好地了解泡沫特性如何影响 出血控制和扩展的临床前表征这个有前途的平台。 为实现这些目标，将努力实现以下具体目标： 具体目的1：评价SMP泡沫结构对体外出血控制的影响 伤口模型，并为不可压缩的躯干伤口设计存储和输送装置， 可压缩的四肢伤口 具体目标2：表征SMP泡沫在不可压缩的V级肝脏中的体内功效 损伤 具体目标3：表征体内SMP泡沫的应用、功效、去除和安全性 压迫性股动脉损伤 在这些研究完成后，预期将有临床相关的SMP泡沫- 用于可压缩和不可压缩创伤的基于止血装置的设计 伤口这些研究的主要积极影响将是止血敷料， 在一系列出血性伤口类型中使用和有效。