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The Impact of In Utero E-Cigarette Exposure on Platelet Function and Thrombogenesis

子宫内电子烟暴露对血小板功能和血栓形成的影响

基本信息

批准号：
10640062
负责人：
Fatima Z. Alshbool
金额：
$ 18.94万
依托单位：
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-08 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640062
关键词：
Address Adult Affect Agonist Animal Diseases Animal Model Anti-Inflammatory Agents Automobile Driving Awareness Biochemical Markers Biology Blood Coagulation Factor Blood Platelets Cardiovascular Diseases Cardiovascular system DNA Methylation Data Development Disease Dose Electronic cigarette Elements Epigenetic Process Exposure to Female Female of child bearing age Foundations Gender Goals Health Hemostatic function Human Mediating MicroRNAs Modeling Morbidity - disease rate Mus Nature Pathogenesis Phenotype Physiological Plasma Platelet Activation Play Policies Pregnant Women Prevention Process Public Health Publishing Risk Role Safety Shapes Smoke Smoking Societies Stimulus Therapeutic Thrombin Thrombosis Thrombus Time Tobacco Tobacco Dependence Tobacco smoking behavior Tobacco use Vulnerable Populations cardiovascular disorder risk cardiovascular health clinically relevant cytokine design developmental plasticity electronic cigarette use electronic liquid evidence base experimental study in utero mortality novel platelet function pregnant prenatal exposure receptor response sex thrombogenesis tobacco control tobacco exposure virtual

项目摘要

While smoking has been on the decline, e-cigarette usage has been on the rise; especially in vulnerable populations, including pregnant women, who switch to e-cigarettes due to misperceptions regarding their safety. Furthermore, even though the contribution of traditional smoking to the pathogenesis of thrombotic diseases is well documented, the involvement of e-cigarettes in such disease processes remains unknown. Consequently, the present application outlines studies that address fundamental, mechanistic, epigenetic and clinically-relevant translational aspects of the adverse-health effects of in utero exposure to e-cigarettes, an increasingly popular form of tobacco, in the context of thrombotic disease and platelet biology, and in an e-liquid-, and sex-specific manner. These studies are of paramount significance given the “perceived safety” of e-cigarettes, and will be conducted using a novel/new whole body exposure model. The Aims of this proposal are: Aim 1. Investigate the impact of in utero e-cigarette exposure on platelet-dependent disease states. While there is compelling evidence that e-cigarettes do exert negative health effects, and that in utero exposure to tobacco contributes to thrombogenesis, whether e-cigarettes are associated with an increased risk of thrombotic diseases is yet to be determined. To address this issue, the consequences of in utero e- cigarette exposure on normal hemostasis and whether it participates in the development of thrombotic diseases will be determined. Subsequent studies will assess the impact of in utero e-cigarettes on clotting factors. Aim 2. Investigate the mechanism by which in utero e-cigarette exposure modulates platelet function. It is noteworthy that published data shows that e-cigarettes do enhance platelet function (e.g., aggregation) in adults. Nonetheless, it remains to be determined if in utero e-cigarettes produce similar effects or not. Thus, the overall goal of the experiments proposed in this section is to determine the mechanism and impact of in utero e-cigarette exposure on the various platelet functional responses, specific biochemical markers of platelet activation, pro- and anti-inflammatory, as well as on the platelet epigenetics. Collectively, these experiments will make major contributions to understanding the consequences of in utero exposure to e-cigarettes on platelet activation and cardiovascular human health, its epigenetics, and the mechanism by/through which they exerts these effects, in an e-liquid- and sex- specific manner.

虽然吸烟人数一直在下降，但电子烟的使用量一直在上升；尤其是弱势群体