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Understanding how social connectedness protects older adults' cognitive health: the role of social cognition

了解社会联系如何保护老年人的认知健康：社会认知的作用

基本信息

批准号：
10642747
负责人：
Anne Catherine Krendl
金额：
$ 71.68万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10642747
关键词：
Acquaintances Affect Aging Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Biological Process Brain Brain region Characteristics Clinical Cognitive Cognitive aging Cognitive deficits Complex Dementia Elderly Exercise Face Family Family member Friends Functional Magnetic Resonance Imaging Funding Goals Health Healthcare Systems Impaired cognition Impairment Individual Infrastructure Interdisciplinary Study Intervention Interview Knowledge Link Longevity Measures Mediating Memory Meta-Analysis Methods Mind Neurocognitive Participant Pathway interactions Peripheral Persons Prevalence Process Public Health Reproducibility Research Research Personnel Resources Rest Role Science Site Social Interaction Social Network Social Processes Structure Taxes Testing Time Work age related burden of illness cognitive ability cognitive function cognitive performance cohort improved innovation insight lifestyle intervention longitudinal design member mental state mild cognitive impairment neurobiological mechanism neuroimaging novel recruit resilience response social social cognition social engagement social implication social interventions social neuroscience social relationships sociodemographic variables theories

项目摘要

PROJECT SUMMARY Social and lifestyle interventions are a promising innovation for delaying the onset of Alzheimer’s disease (AD) and related dementias. Extensive work has shown that maintaining social connectedness through personal social networks (the group of family members, friends, and other acquaintances in which individuals are socially embedded) confers resilience to cognitive decline and AD. The current proposal uses an interdisciplinary and multi-method approach to elucidate the mechanism by which this occurs. To date, existing research has focused on the implications of social networks for one neurocognitive pathway – general cognitive ability. The current proposal tests the novel prediction that a different pathway – social cognitive function – is a key component underlying the linkages between social networks, general cognitive function, and AD resilience. Social cognitive function – the process by which people understand, store, and apply information about others – is essential for successfully navigating social interactions, and declines over the lifespan. The proposed work explores the prediction that exercising social cognitive abilities through complex social interactions within their personal social networks stimulates older adults’ general cognitive function, thereby improving their resilience. In Aim 1, we examine the relationship between older adults’ social networks and their social cognitive function, as well as the possibility that having better social cognitive function may be protective for general cognitive function. Aim 2 uses a novel neuroimaging approach to identify the neurobiological mechanisms that give rise to the relationship between social networks and social cognitive function. Finally, Aim 3 uses a longitudinal design to gain insight into the causal relationship between social network dynamics, social cognitive decline, and general cognitive decline. The proposed study is interdisciplinary, combining cutting-edge methods from the social and biomedical sciences, and leveraging the resources of funded centers for AD, neuroimaging, and network science. The long-term goal of this project is to improve the clinical course of AD, and reduce the prevalence and public health impact of dementia. By increasing our understanding of the links between biological and social processes, this project may help identify novel targets for intervention to reduce the burden of AD on individuals, families, and the health care system.

项目概要社会和生活方式干预是延缓疾病发生的一项有前途的创新阿尔茨海默氏病 (AD) 和相关痴呆症。大量的工作表明通过个人社交网络（家庭群体）维持社会联系成员、朋友和个人融入社会的其他熟人）赋予对认知能力下降和 AD 的恢复能力。当前的提案使用跨学科和多方法的方法来阐明这一机制发生。迄今为止，现有的研究主要集中在社交网络对一种神经认知途径——一般认知能力。目前的提案测试了新颖的预测表明不同的途径——社会认知功能——是一个关键组成部分社交网络、一般认知功能和 AD 之间联系的基础弹力。社会认知功能——人们理解、存储、并应用有关他人的信息——对于成功驾驭社交至关重要相互作用，并在整个生命周期中下降。拟议的工作探讨了预测通过复杂的社交互动来锻炼社交认知能力个人社交网络刺激老年人的一般认知功能，从而提高他们的适应能力。在目标 1 中，我们研究了老年人的社交网络及其社交认知功能，以及拥有的可能性更好的社会认知功能可能对一般认知功能有保护作用。目标2 使用一种新颖的神经影像学方法来识别神经生物学机制引起社交网络与社会认知功能之间的关系。最后，目标3采用纵向设计来洞察因果关系社交网络动态、社交认知衰退和一般认知之间的关系衰退。拟议的研究是跨学科的，结合了前沿方法来自社会和生物医学科学，并利用资助的资源 AD、神经影像和网络科学中心。本项目的长期目标是为了改善 AD 的临床病程，并降低患病率和公共卫生痴呆症的影响。通过增加我们对生物之间联系的理解和社会进程，该项目可能有助于确定新的干预目标减轻 AD 对个人、家庭和医疗保健系统的负担。