The Graduate Program in Tropical Infectious Diseases (GPiTID)

热带传染病研究生项目 (GPiTID)

• 批准号: 10641789
• 负责人: Phyllis J. Kanki
• 金额: $ 20.78万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10641789
• 关键词: Communicable Diseases; programs

This proposal is the renewal of a training initiative for predoctoral training in Tropical Infectious Diseases, now called The Graduate Program in Tropical Infectious Diseases (GPiTID) and requests funding for six trainees for five years. The goal of this training grant is two-fold: to train the next generation of global health leaders and to train students to advance scientific achievements toward the control of infectious diseases. The GPiTID is distinct in many aspects – the training is embedded in a school of public health but focuses on the fundamental scientific discovery using cutting edge approaches of genomics, cell biology, immunology, population biology and gene editing coupled with the epidemiology of diseases in their natural setting to address major infections both that pose a threat to public health both in the US and abroad. There is a focus on fundamental scientific training but in the context of the diseases as holistic problems and with an emphasis on fundamental discoveries that could lead to new interventions including drug, vaccine and insecticide development. The Principal Investigators of the program are Professor Dyann Wirth, Richard Pearson Strong Professor, Department of Immunology and Infectious Diseases, Senior Associate Member at the Broad Institute, and Faculty Chair of the Harvard Integrated Life Sciences (HILS) Ph.D. Program, Professor Phyllis Kanki of the Department of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health and Professor Eric Rubin, the Irene Heinz Given Professor and Chair, Department of Immunology and Infectious Diseases. The training program will be housed in the Department of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health, centrally located in the Longwood Medical Area of Boston, MA. Trainees have the opportunity to interact with students from diverse professional and personal backgrounds including a large number of international students from countries where infectious diseases remain a major health threat, leading to over 50% of overall early childhood morality in many countries and devastating young adult populations in their most productive years. The trainees in GPiTID attend introductory classes in epidemiology, biostatistics and the history of public health with students from all HSPH academic programs including the professional degrees of MPH and DrPH. The GPiTID also offers students opportunities at the interface of laboratory science and translational applications in the form of two special programs, one an opportunity to conduct part of their thesis work in a disease endemic setting and a second to train in the Clinical-Laboratory Partnership in Infectious Disease (CLP-ID) program. Appointments will be in 1-year intervals.

这项提议是对热带传染病博士前培训计划的更新 疾病，现在称为热带传染病研究生课程(GPiTID)和 要求为六名受训人员提供为期五年的资助。这笔培训补助金的目标有两个：培训 下一代全球卫生领导者和培养学生推进科学 在控制传染病方面取得的成就。GPiTID在许多方面都是不同的 -培训嵌入公共卫生学院，但侧重于基础科学 使用基因组学、细胞生物学、免疫学、种群的前沿方法进行发现 生物学和基因编辑与自然环境下的疾病流行病学相结合， 应对对美国和国外公共卫生构成威胁的重大感染。 重点放在基础科学培训上，但在疾病方面是整体性的 问题，并强调可能导致新干预措施的根本性发现 包括药物、疫苗和杀虫剂的开发。该项目的首席调查员 分别是免疫学系Dyann Wirth教授、Richard Pearson Strong教授和 传染病，布罗德研究所高级准会员， 哈佛大学综合生命科学(HILS)博士项目， 哈佛大学公共卫生学院免疫学和传染病系 健康与埃里克·鲁宾教授，艾琳·海因茨教授 免疫学和传染病。培训方案将设在 哈佛大学公共卫生学院免疫学和传染病， 位于马萨诸塞州波士顿的朗伍德医疗区。实习生有机会 与来自不同专业和个人背景的学生互动，包括 来自传染病仍是主要疾病的国家的国际学生人数 健康威胁，导致许多国家和地区儿童道德总水平的50%以上 在他们生产力最高的年龄段，这对年轻的成年人造成了毁灭性的打击。GPiTID的学员 参加流行病学、生物统计学和公共卫生史的入门课程 来自HSPH所有学术项目的学生，包括公共卫生硕士和公共卫生硕士专业学位 博士。GPiTID还为学生提供实验室科学和 翻译申请以两个特别计划的形式进行，其中一个有机会进行部分 他们的论文中有一半是在疾病流行的背景下工作，另一个是在临床实验室接受培训 传染病伙伴关系(CLP-ID)计划。预约将每隔一年进行一次。

项目成果

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.

恶性疟原虫对二氢乳清酸脱氢酶抑制剂的附带敏感性的鉴定。

• DOI: 10.1021/acsinfecdis.7b00217
• 发表时间: 2018
• 期刊: ACS infectious diseases
• 影响因子: 5.3
• 作者: Ross,LeilaSaxby;Lafuente-Monasterio,MariaJosé;Sakata-Kato,Tomoyo;Mandt,RebeccaEK;Gamo,FranciscoJavier;Wirth,DyannF;Lukens,AmandaK
• 通讯作者: Lukens,AmandaK

The Intracellular Amastigote of Trypanosoma cruzi Maintains an Actively Beating Flagellum.

• DOI: 10.1128/mbio.03556-22
• 发表时间: 2023-04-25
• 期刊: mBio
• 影响因子: 6.4

The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas.

• DOI: 10.1128/mbio.01092-17
• 发表时间: 2017-08-15
• 期刊: mBio
• 影响因子: 6.4
• 作者: Kurthkoti K;Amin H;Marakalala MJ;Ghanny S;Subbian S;Sakatos A;Livny J;Fortune SM;Berney M;Rodriguez GM
• 通讯作者: Rodriguez GM

Tools for Anopheles gambiae Transgenesis.

• DOI: 10.1534/g3.115.016808
• 发表时间: 2015-04-13
• 期刊: G3 (Bethesda, Md.)
• 作者: Volohonsky G;Terenzi O;Soichot J;Naujoks DA;Nolan T;Windbichler N;Kapps D;Smidler AL;Vittu A;Costa G;Steinert S;Levashina EA;Blandin SA;Marois E
• 通讯作者: Marois E

Engineering the control of mosquito-borne infectious diseases.

• DOI: 10.1186/s13059-014-0535-7
• 发表时间: 2014-11-15
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Gabrieli P;Smidler A;Catteruccia F
• 通讯作者: Catteruccia F