Detecting and classifying non-fluent speech in aphasia using machine learning

使用机器学习对失语症患者的不流利言语进行检测和分类

• 批准号: 10647054
• 负责人: Claire Elizabeth Cordella
• 金额: $ 0.25万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647054
• 关键词: Acoustics; Affect; American; Aphasia; Articulation; Clinical; Code; Cognitive; Communication; Databases; Diagnostic; Feeling; Functional disorder; Future; Goals; Impaired cognition; Impairment; Individual; Intervention; Language; Life; Light; Linear Regressions; Linguistics; Long-Term Effects; Machine Learning; Measures; Mental Depression; Modeling; Monitor; Motor; Output; Patients; Persons; Population; Predictive Value; Proxy; Research; Sampling; Scheme; Social isolation; Source; Speech; Standardization; Surface; Techniques; Testing; Time; Training; Validation; Work; accurate diagnosis; cognitive function; cohort; disability; experience; functional outcomes; indexing; inter-individual variation; interest; language impairment; lexical retrieval; machine learning classifier; novel; novel diagnostics; novel strategies; post stroke; predictive modeling; prospective; recruit; social; stroke-induced aphasia; supervised learning; syntax; treatment planning; treatment response

PROJECT SUMMARY Among the approximately 2 million Americans living with post-stroke aphasia, many experience difficulties with verbal expression that render everyday communication effortful, inefficient, and stressful.1,32 For persons with aphasia (PWA), speech non-fluency is often experienced as a visible disability with significant social consequences.36,37 Given this functional salience, speech fluency is an important construct to assess, monitor, and treat. It is, however, a longstanding clinical challenge to index fluency in a way that is comprehensive, interpretable, and efficient,7 and current approaches rely on either expert clinician ratings or time-intensive linguistic analyses using detailed coding. Temporal acoustic measures, by contrast, are objective measures that can be automatically or semi-automatically derived from connected speech. Prior research has demonstrated that the rate and rhythm of speech output reflect underlying impairments in both speech and language (e.g., motor speech, lexical retrieval), suggesting the utility of temporal acoustic measures to index non-fluency in PWA. The goal of the current study is to investigate the feasibility of using automated temporal acoustic features to identify non-fluent aphasia and to better understand the latent speech, language, and cognitive constructs underlying these surface speech features. To achieve this goal, we leverage machine learning techniques as part of a predictive modeling approach to identify speech features whose clinical utility can be generalized to inform future assessment of fluency in aphasia. In Aim 1, we will investigate whether temporal acoustic features accurately predict fluency status using a supervised machine learning approach (Aim 1a), and which features are most important to clinical distinctions of interest (fluent v. non-fluent; present v. absent motor speech impairment; Aim 1b). In Aim 2, we will determine the underlying speech, language, and cognitive contributors to inter-individual variability in temporal acoustic measures, thereby augmenting the explanatory power of study results. These aims are a first step toward an interpretable and automatable predictive model of fluency in PWA that can be generalized to novel diagnostic situations. Results of this research will help clinicians identify important features for efficient assessment of and treatment planning for patients as well as provide a mechanistic understanding of surface level features by mapping those features to explanatory clinical sub-constructs.

项目总结