SPeCTRE 2.0: The Sunflower Pediatric Clinical Trials Research Extension

项目摘要/摘要 生活在农村和服务不足社区的儿童健康状况较差，健康状况也较差 而不是生活在其他地区的儿童。我们的堪萨斯州就是这个问题的例证，农村儿童的死亡率较低。 免疫接种率、婴儿死亡率和肥胖率高于城市和郊区 对口单位。此外，来自农村和服务不足地区的儿童和家庭更不可能参与 临床试验，可以研究这些和其他健康状况，并最终导致健康状况的改善 对于这些农村和未得到充分服务的儿童和家庭。本申请的目的是建议 堪萨斯州，一个以农村为主的州，更新了其作为儿童健康结果临床站点的地位 (ECHO)IDEA国家儿科临床试验网络(ISPCTN)。我们使用此应用程序的目标是：1) 确保堪萨斯州农村和服务不足的儿童参与多中心临床试验研究，以及2) 完善我州儿科临床试验基础设施。目前的应用，向日葵儿科 临床试验研究扩展(SPECTE 2.0)有三个主要目标，专注于改善研究 通过我们州临床医生和研究人员的专业技能发展，扩大临床 在我们州对农村和服务不足的儿童进行试验，并评估和改进 网络中临床试验的效率。我们建议有一个强大的管理团队和详细的管理 计划支持这项工作，并在全州拥有广泛的网络来支持我们的活动，如 有计划的。我们的网站在最初的资金周期中非常富有成效，并将在#年扩大这些活动 幽灵2.0。我们提出了一个非常强大的临床技能发展计划，重点是实施科学 和个性化的培训计划，充分利用我们强大的现有校园资源和我们的临床 堪萨斯州的翻译科学奖(CTSA)被称为前沿。正如我们的农村参与计划中指出的那样， 我们计划通过我们的初级临床站点和我们的利益相关者吸引社区和提供商 咨询委员会网站。我们还注意到，堪萨斯州是一个高度农村的州，有大量的儿科 我们将把农村和未得到充分服务的患者带到网络中。最后，我们的应用程序包括一个 疫苗教育与研究合作课程的临床试验方案， 这是一项试验，该网络可能会考虑进行潜在的未来传播。评选结果 目前的工作可能会改善堪萨斯州农村儿童和服务不足儿童的健康状况 以及改善我们的想法状态的基础设施，以支持未来的儿科临床试验。

Project Summary/Abstract Children living in rural and underserved communities experience poorer health and worse health outcomes than children living in other areas. Our state, Kansas, exemplifies this problem, with rural children having lower immunization rates, higher infant mortality rates, and higher rates of obesity than their urban and suburban counterparts. Also, children and families from rural and underserved areas are much less likely to participate in clinical trials, which could study these and other health conditions and ultimately lead to improvement in health for these rural and underserved children and families. The purpose of the current application is to propose that the state of Kansas, a largely rural state, renew its status as a Clinical Site of the Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ISPCTN). Our goals with this application are: 1) to assure that rural and underserved children in Kansas participate in multicenter clinical trials research, and 2) to improve the infrastructure for pediatric clinical trials in our state. The current application, Sunflower Pediatric Clinical Trials Research Extension (SPeCTRE 2.0), has three primary aims focused on improving research capacity through professional skills development of clinicians and researchers in our state, expanding clinical trials to rural and underserved children in our state, and evaluating and improving the effectiveness and efficiency of clinical trials in the network. We propose a strong administrative team and detailed administrative plan to support this work and have an extensive network throughout our state to support our activities as planned. Our site was very productive during the initial funding cycle and will expand on these activities during SPeCTRE 2.0. We propose a very strong Clinical Skills Development Plan focused on implementation science and individualized training plans that capitalizes upon our strong existing campus resources and our Clinical and Translational Science Award (CTSA) in Kansas called Frontiers. As noted in our Rural Engagement Plan, we plan to engage both communities and providers through our Primary Clinical Sites and our Stakeholder Advisory Committee Sites. We also note that Kansas is a highly rural state with a high volume of pediatric patients who are rural and underserved who we will bring to the network. Finally, our application includes a Clinical Trial Proposal of the CoVER (The Collaboration for Vaccine Education and Research) curriculum, which is a trial that may be considered by the network for potential future dissemination. The results of the current work could lead to improvement in the health of rural and underserved children in the state of Kansas and improvements in the infrastructure in our IDeA state to support future pediatric clinical trials.