Cognitive Health and Modifiable Factors of Daily Sleep and Activities Among Dementia Family Caregivers

痴呆症家庭护理人员的认知健康状况以及日常睡眠和活动的可改变因素

• 批准号: 10643624
• 负责人: Yin Liu
• 金额: $ 13.98万
• 依托单位: UTAH STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643624
• 关键词: Abbreviations; Acceleration; Accelerometer; Activities of Daily Living; Address; Affect; Aging; Alzheimer' s disease related dementia; American; Anxiety; Area; Behavior; Biological; Biological Markers; Caregivers; Caring; Characteristics; Chronic stress; Clinical; Cognition; Cognitive; Communities; Complex; Data Reporting; Dementia; Dementia caregivers; Development; Distress; Education; Elderly; Elements; Emotional; Evidence based intervention; Exercise; Family; Family Caregiver; Friends; Future; Goals; Growth; Hair; Health; Health behavior; Hydrocortisone; Individual; Institutionalization; Intervention; K-Series Research Career Programs; Knowledge; Link; Measures; Mediating; Mental Depression; Mental Health; Mentors; Mentorship; Music; Neurocognitive; Outcome; Patient Self-Report; Personal Satisfaction; Persons; Quality of Care; Regulation; Research; Research Personnel; Risk; Risk Factors; Science; Scientist; Severities; Sleep; Sleep disturbances; Social Controls; Social Environment; Socialization; Specific qualifier value; Stress; Training; Training Programs; actigraphy; age related; aging population; anxiety symptoms; biobehavior; biopsychosocial; care giving burden; career; caregiver interventions; caregiving; caregiving research; clinical care; cognitive benefits; cognitive function; comorbidity; dementia care; dementia caregiving; demographics; depressive symptoms; design; diaries; disability; experience; family caregiving; follow-up; improved; informal care; innovation; insight; interest; longitudinal design; member; mortality; multilevel analysis; neuropsychiatric symptom; novel; poor sleep; preservation; primary caregiver; programs; promote resilience; protective factors; residence; resilience; skills; sleep behavior; sleep health; sleep quality; sleep regulation; social; therapy design

PROJECT SUMMARY Approximately 16 million Americans serve as family caregivers for a person with Alzheimer's disease and related dementias and this care can take a physical and emotional toll. Understudied is how this informal care can affect caregiver cognitive health and associated daily sleep and activities, all of which are modifiable health behaviors. Engaging in personally meaningful, and cognitively stimulating activities can benefit cognitive and sleep health among dementia care dyads. Despite the importance of activity engagement for cognitive functioning and sleep quality, existing assessment of activities and outcomes is often self-reported asynchronously at global levels. Contemporaneous assessment of activities, sleep, and cognitive health and well-being would significantly advance research in this area by 1) conducting objective assessments on daily sleep and activities within a dyadic context, 2) determining how the social context of caregivers' assistance for the individuals with dementia's activity engagement moderates the associations between cognitive health and well-being, and daily sleep and activities, and 3) determining how a chronic stress biomarker, hair cortisol concentration, mediates the activities- and sleep-cognition associations in naturalistic settings. The proposed mentored career development award combines a rigorous program of research, mentorship, and didactics to facilitate the candidate's growth toward an overall career goal of becoming an independent investigator focused on informing the design of interventions for aging caregiving dyads with complex care needs including dementia to improve both partners' well- being. The training aims will assist the candidate in acquiring: 1) grounded knowledge of clinical care and educational needs among care dyads relating to neurocognitive assessment, functioning, and understanding the clinical aspects of dementia, 2) specialized skills in the assessment, analysis, and interpretation of daily sleep and activity measures and the biological measure of chronic stress that link to the dementia care situation and specifically to caregiver cognitive health and well-being, and 3) expertise in the application of intensive repeated measures designs that will generate novel insights on proximal risk and protective factors for poor caregiver outcomes within the dyadic context. The training aims seek to further develop the candidate's expertise as an interdisciplinary researcher in the area of later-life dementia family caregiving and align closely with the research aims to: 1) quantify caregiver daily sleep characteristics with actigraphy and determine their associations with caregiver cognitive functioning and well-being; 2) quantify caregiver daily activity characteristics with accelerometry and determine their associations with caregiver cognitive functioning and well-being; and 3) To characterize how caregiver assistance for PLwD's activity engagement moderates, and how hair cortisol concentration mediates associations of sleep➔cognition and activities➔cognition. An integrated, biopsychosocial approach to identifying protective factors that promote resilience and reduce harmful risk factors will inform the development of future targeted caregiver interventions in the dyadic context for a highly vulnerable aging population.

项目摘要 大约有1600万美国人担任阿尔茨海默病患者及其相关疾病的家庭照顾者。 痴呆症和这种照顾可以采取身体和情感的代价。未充分研究的是这种非正式护理如何影响护理人员 认知健康和相关的日常睡眠和活动，所有这些都是可改变的健康行为。从事 个人有意义的，认知刺激活动可以有益于痴呆症护理中的认知和睡眠健康 二分体尽管活动参与对认知功能和睡眠质量的重要性，但现有的评估 在全球一级，活动和成果的自我报告往往是不同步的。对活动的同期评估， 睡眠，认知健康和幸福将大大推进这一领域研究，1）进行客观的 在二元背景下对日常睡眠和活动进行评估，2）确定照顾者的社会背景如何 对痴呆症患者的活动参与的帮助调节了认知健康 和健康，以及日常睡眠和活动，以及3）确定慢性压力生物标志物，头发皮质醇 集中，介导的活动和睡眠认知协会在自然的设置。拟议的指导 职业发展奖结合了严格的研究计划，指导，和教学法，以促进候选人的 成长为一个整体的职业目标，成为一个独立的调查员，重点是通知设计 针对老年人的干预措施，包括痴呆症，以改善双方的健康， 存在培训目标将帮助候选人获得：1）临床护理和教育的基础知识 护理二人组中与神经认知评估、功能和理解临床方面有关的需求 痴呆症，2）评估，分析和解释日常睡眠和活动措施的专业技能， 慢性压力的生物学测量，与痴呆症护理情况，特别是护理人员的认知健康有关 和福祉，以及3）在应用密集的重复测量设计，将产生新的见解的专业知识 在二元背景下，对护理者结果不佳的近端风险和保护因素进行研究。培训的目的是 进一步发展候选人作为晚年痴呆症家庭领域跨学科研究人员的专业知识 与研究目标密切相关并保持一致：1）使用活动记录仪量化护理人员的日常睡眠特征 并确定其与照顾者认知功能和幸福感的关联; 2）量化照顾者的日常活动 特征与加速度计，并确定其与护理人员的认知功能和福祉的关联; 以及3）描述PLwD的活动参与的护理人员帮助如何调节，以及头发皮质醇如何调节PLwD的活动参与。 注意力集中介导睡眠-认知和活动-认知的关联。一个综合的，生物心理社会的 确定促进复原力和减少有害风险因素的保护因素的方法将为 为高度脆弱的老龄化人口制定未来有针对性的护理干预措施。