Impact of vestibular loss on central vestibular pathways in aging adults

前庭丧失对老年人中枢前庭通路的影响

基本信息

  • 批准号:
    10643891
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-15 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

Emerging research is providing compelling evidence that the vestibular system contributes not only to basic reflexes (e.g. vestibulo-ocular, postural) but also to complex cognitive processes including spatial memory and navigation; self-motion perception and motor planning; and executive function. Vestibular function declines with healthy aging, and studies from our group and others have shown that vestibular loss in aging adults is associated with known age-related reductions in cognitive skills including spatial memory and navigation ability, and self-motion perception and motor planning. In a pilot study supported by the NIDCD, we found that older adults with vestibular loss had reduced hippocampal volumes, as well as atrophy of subfields of the thalamus and the basal ganglia. During this pilot study, our group built a pipeline for analysis of neuroimaging data from the Baltimore Longitudinal Study of Aging (BLSA) at the Center for Imaging Science (CIS) in the Johns Hopkins Department of Biomedical Engineering. We established the computational infrastructure for both volumetric analysis and shape analysis. In this proposal, we seek to leverage this infrastructure to more comprehensively investigate the impact of aging on three core central vestibular pathways, and examine the link between structural changes in these pathways and functional changes in clinical skills mediated by these pathways. Specifically, we aim to: Aim 1 Investigate the relationship between peripheral vestibular sensory loss associated with aging and the structure of central vestibular pathways, specifically considering 3 primary central vestibular pathways: 1) spatial cognitive; 2) sensorimotor; 3) prefrontal cortex (executive function). Aim 2 Examine the longitudinal relationships between peripheral vestibular loss and structural changes in central vestibular pathways using longitudinal models and also the novel change-point model in aging adults. Aim 3 Explore the association between structural changes in central vestibular pathways and clinical functional changes cross-sectionally and longitudinally. This proposal represents a unique opportunity to leverage strengths in vestibular physiology and computational neuroimaging to increase our fundamental understanding of the impact of healthy aging on central vestibular networks, and associated clinical consequences. Findings from this study will be used to drive further critical research questions, including 1) Does vestibular loss contribute to the accelerated decline in cognitive ability and brain structure that occurs in individuals with cognitive impairment and Alzheimer’s disease; and 2) Can vestibular interventions for vestibular loss prevent/mitigate changes in central vestibular pathways?
新兴研究提供了令人信服的证据,证明前庭系统不仅有助于基本功能 反射(例如前庭眼反射、姿势反射)以及复杂的认知过程,包括空间记忆 和导航;自我运动感知和运动规划;和执行功能。前庭功能 随着健康的衰老而下降,我们小组和其他人的研究表明,随着年龄的增长,前庭功能的丧失 成年人与已知的与年龄相关的认知技能(包括空间记忆和认知能力)下降有关。 导航能力、自我运动感知和运动规划。在 NIDCD 支持的一项试点研究中, 我们发现,患有前庭丧失的老年人的海马体积减少,并且大脑萎缩。 丘脑和基底神经节的子区域。在这项试点研究中,我们小组建立了一个分析管道 来自成像中心巴尔的摩纵向衰老研究 (BLSA) 的神经影像数据 约翰霍普金斯大学生物医学工程系科学(CIS)。我们建立了 用于体积分析和形状分析的计算基础设施。在本提案中,我们力求 利用这一基础设施更全面地调查老龄化对三个核心中枢的影响 前庭通路,并检查这些通路的结构变化和功能之间的联系 这些途径介导的临床技能的变化。具体来说,我们的目标是: 目标 1 调查 衰老相关外周前庭感觉丧失与中枢结构的关系 前庭通路,特别考虑 3 个主要的中枢前庭通路:1)空间认知; 2) 感觉运动; 3)前额皮质(执行功能)。目标 2 检查纵向关系 使用纵向研究外周前庭损失与中央前庭通路结构变化之间的关系 模型以及老年人的新颖变点模型。目标 3 探索之间的关联 中央前庭通路的结构变化和临床功能的横断面变化 纵向。该提案代表了利用前庭生理学优势的独特机会 和计算神经影像,以增进我们对健康老龄化影响的基本了解 中枢前庭网络以及相关的临床后果。这项研究的结果将被用于 推动进一步的关键研究问题,包括 1) 前庭损失是否会导致加速 认知障碍患者的认知能力和大脑结构下降 阿尔茨海默病; 2) 针对前庭功能丧失的前庭干预能否预防/减轻前庭功能的变化? 中枢前庭通路?

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Yuri Agrawal其他文献

Yuri Agrawal的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Yuri Agrawal', 18)}}的其他基金

Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
前庭疗法减少阿尔茨海默病患者跌倒的临床试验
  • 批准号:
    10611308
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Impact of vestibular loss on central vestibular pathways in aging adults
前庭丧失对老年人中枢前庭通路的影响
  • 批准号:
    10274617
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Impact of vestibular loss on central vestibular pathways in aging adults
前庭丧失对老年人中枢前庭通路的影响
  • 批准号:
    10487441
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
前庭疗法减少阿尔茨海默病患者跌倒的临床试验
  • 批准号:
    10341139
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Impact of vestibular loss on central vestibular pathways in aging adults
前庭丧失对老年人中枢前庭通路的影响
  • 批准号:
    10990150
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
前庭疗法减少阿尔茨海默病患者跌倒的临床试验
  • 批准号:
    10993253
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Contribution of sensorimotor function to risk and pathogenic mechanisms of Alzheimer's disease and related dementias
感觉运动功能对阿尔茨海默病和相关痴呆的风险和致病机制的贡献
  • 批准号:
    10318172
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Contribution of sensorimotor function to risk and pathogenic mechanisms of Alzheimer's disease and related dementias
感觉运动功能对阿尔茨海默病和相关痴呆的风险和致病机制的贡献
  • 批准号:
    10534237
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Does vestibular loss predict falls in patients with Alzheimer's Disease?
前庭丧失是否预示着阿尔茨海默病患者会跌倒?
  • 批准号:
    9915832
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
Does vestibular loss predict falls in patients with Alzheimer's Disease?
前庭丧失是否预示着阿尔茨海默病患者会跌倒?
  • 批准号:
    9763435
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
  • 批准号:
    24K16488
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
  • 批准号:
    10100360
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
  • 批准号:
    24K04974
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
  • 批准号:
    23K01686
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
  • 批准号:
    23K01692
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
  • 批准号:
    23K01695
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
  • 批准号:
    23K01713
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
  • 批准号:
    2312319
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
  • 批准号:
    23K01715
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
  • 批准号:
    10585388
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了