Impact of vestibular loss on central vestibular pathways in aging adults
前庭丧失对老年人中枢前庭通路的影响
基本信息
- 批准号:10487441
- 负责人:
- 金额:$ 40.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAdultAgingAlzheimer&aposs DiseaseAnimal ModelAnteriorArithmeticAtrophicBaltimoreBasal GangliaBiomedical EngineeringBrainBrain regionCell NucleusClinicalClinical SkillsCognitiveComplexDataDorsalElderlyEquilibriumGaitGrantHippocampus (Brain)HumanImage AnalysisImpaired cognitionIndividualInfrastructureInterventionLabyrinthLinkLongitudinal StudiesMagnetic Resonance ImagingMeasuresMediatingModelingMotion PerceptionMotorMotor CortexNamesNational Institute on Deafness and Other Communication DisordersNeuraxisParietalPathway interactionsPerformancePeripheralPhysiologyPilot ProjectsPosturePrefrontal CortexPublic HealthReflex actionResearchSensorySignal TransductionSomatosensory CortexStructureSystemTechniquesThalamic structureTimeVentral Lateral Thalamic NucleusVentral Posterior NucleusVestibular lossVestibular nucleus structureage relatedanalysis pipelineanimal databehavior measurementcognitive abilitycognitive processcognitive skillcomputer infrastructureemerging adultexecutive functionhealthy agingimaging facilitiesimaging scienceneurocognitive testneuroimagingnovelpreventputamensensory systemshape analysisskillsspatial memoryvestibular pathwayway finding
项目摘要
Emerging research is providing compelling evidence that the vestibular system contributes not only to basic
reflexes (e.g. vestibulo-ocular, postural) but also to complex cognitive processes including spatial memory
and navigation; self-motion perception and motor planning; and executive function. Vestibular function
declines with healthy aging, and studies from our group and others have shown that vestibular loss in aging
adults is associated with known age-related reductions in cognitive skills including spatial memory and
navigation ability, and self-motion perception and motor planning. In a pilot study supported by the NIDCD,
we found that older adults with vestibular loss had reduced hippocampal volumes, as well as atrophy of
subfields of the thalamus and the basal ganglia. During this pilot study, our group built a pipeline for analysis
of neuroimaging data from the Baltimore Longitudinal Study of Aging (BLSA) at the Center for Imaging
Science (CIS) in the Johns Hopkins Department of Biomedical Engineering. We established the
computational infrastructure for both volumetric analysis and shape analysis. In this proposal, we seek to
leverage this infrastructure to more comprehensively investigate the impact of aging on three core central
vestibular pathways, and examine the link between structural changes in these pathways and functional
changes in clinical skills mediated by these pathways. Specifically, we aim to: Aim 1 Investigate the
relationship between peripheral vestibular sensory loss associated with aging and the structure of central
vestibular pathways, specifically considering 3 primary central vestibular pathways: 1) spatial cognitive; 2)
sensorimotor; 3) prefrontal cortex (executive function). Aim 2 Examine the longitudinal relationships
between peripheral vestibular loss and structural changes in central vestibular pathways using longitudinal
models and also the novel change-point model in aging adults. Aim 3 Explore the association between
structural changes in central vestibular pathways and clinical functional changes cross-sectionally and
longitudinally. This proposal represents a unique opportunity to leverage strengths in vestibular physiology
and computational neuroimaging to increase our fundamental understanding of the impact of healthy aging
on central vestibular networks, and associated clinical consequences. Findings from this study will be used
to drive further critical research questions, including 1) Does vestibular loss contribute to the accelerated
decline in cognitive ability and brain structure that occurs in individuals with cognitive impairment and
Alzheimer’s disease; and 2) Can vestibular interventions for vestibular loss prevent/mitigate changes in
central vestibular pathways?
新兴的研究提供了令人信服的证据,表明前庭系统不仅对基本神经系统有贡献
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Yuri Agrawal其他文献
Yuri Agrawal的其他文献
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{{ truncateString('Yuri Agrawal', 18)}}的其他基金
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
前庭疗法减少阿尔茨海默病患者跌倒的临床试验
- 批准号:
10611308 - 财政年份:2021
- 资助金额:
$ 40.94万 - 项目类别:
Impact of vestibular loss on central vestibular pathways in aging adults
前庭丧失对老年人中枢前庭通路的影响
- 批准号:
10274617 - 财政年份:2021
- 资助金额:
$ 40.94万 - 项目类别:
Impact of vestibular loss on central vestibular pathways in aging adults
前庭丧失对老年人中枢前庭通路的影响
- 批准号:
10643891 - 财政年份:2021
- 资助金额:
$ 40.94万 - 项目类别:
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
前庭疗法减少阿尔茨海默病患者跌倒的临床试验
- 批准号:
10341139 - 财政年份:2021
- 资助金额:
$ 40.94万 - 项目类别:
Impact of vestibular loss on central vestibular pathways in aging adults
前庭丧失对老年人中枢前庭通路的影响
- 批准号:
10990150 - 财政年份:2021
- 资助金额:
$ 40.94万 - 项目类别:
Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease
前庭疗法减少阿尔茨海默病患者跌倒的临床试验
- 批准号:
10993253 - 财政年份:2021
- 资助金额:
$ 40.94万 - 项目类别:
Contribution of sensorimotor function to risk and pathogenic mechanisms of Alzheimer's disease and related dementias
感觉运动功能对阿尔茨海默病和相关痴呆的风险和致病机制的贡献
- 批准号:
10318172 - 财政年份:2019
- 资助金额:
$ 40.94万 - 项目类别:
Contribution of sensorimotor function to risk and pathogenic mechanisms of Alzheimer's disease and related dementias
感觉运动功能对阿尔茨海默病和相关痴呆的风险和致病机制的贡献
- 批准号:
10534237 - 财政年份:2019
- 资助金额:
$ 40.94万 - 项目类别:
Does vestibular loss predict falls in patients with Alzheimer's Disease?
前庭丧失是否预示着阿尔茨海默病患者会跌倒?
- 批准号:
9915832 - 财政年份:2018
- 资助金额:
$ 40.94万 - 项目类别:
Does vestibular loss predict falls in patients with Alzheimer's Disease?
前庭丧失是否预示着阿尔茨海默病患者会跌倒?
- 批准号:
9763435 - 财政年份:2018
- 资助金额:
$ 40.94万 - 项目类别:
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