Impact of vestibular loss on central vestibular pathways in aging adults

前庭丧失对老年人中枢前庭通路的影响

• 批准号: 10487441
• 负责人: Yuri Agrawal
• 金额: $ 40.94万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10487441
• 关键词: Accounting; Adult; Aging; Alzheimer' s Disease; Animal Model; Anterior; Arithmetic; Atrophic; Baltimore; Basal Ganglia; Biomedical Engineering; Brain; Brain region; Cell Nucleus; Clinical; Clinical Skills; Cognitive; Complex; Data; Dorsal; Elderly; Equilibrium; Gait; Grant; Hippocampus (Brain); Human; Image Analysis; Impaired cognition; Individual; Infrastructure; Intervention; Labyrinth; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Modeling; Motion Perception; Motor; Motor Cortex; Names; National Institute on Deafness and Other Communication Disorders; Neuraxis; Parietal; Pathway interactions; Performance; Peripheral; Physiology; Pilot Projects; Posture; Prefrontal Cortex; Public Health; Reflex action; Research; Sensory; Signal Transduction; Somatosensory Cortex; Structure; System; Techniques; Thalamic structure; Time; Ventral Lateral Thalamic Nucleus; Ventral Posterior Nucleus; Vestibular loss; Vestibular nucleus structure; age related; analysis pipeline; animal data; behavior measurement; cognitive ability; cognitive process; cognitive skill; computer infrastructure; emerging adult; executive function; healthy aging; imaging facilities; imaging science; neurocognitive test; neuroimaging; novel; prevent; putamen; sensory system; shape analysis; skills; spatial memory; vestibular pathway; way finding

Emerging research is providing compelling evidence that the vestibular system contributes not only to basic reflexes (e.g. vestibulo-ocular, postural) but also to complex cognitive processes including spatial memory and navigation; self-motion perception and motor planning; and executive function. Vestibular function declines with healthy aging, and studies from our group and others have shown that vestibular loss in aging adults is associated with known age-related reductions in cognitive skills including spatial memory and navigation ability, and self-motion perception and motor planning. In a pilot study supported by the NIDCD, we found that older adults with vestibular loss had reduced hippocampal volumes, as well as atrophy of subfields of the thalamus and the basal ganglia. During this pilot study, our group built a pipeline for analysis of neuroimaging data from the Baltimore Longitudinal Study of Aging (BLSA) at the Center for Imaging Science (CIS) in the Johns Hopkins Department of Biomedical Engineering. We established the computational infrastructure for both volumetric analysis and shape analysis. In this proposal, we seek to leverage this infrastructure to more comprehensively investigate the impact of aging on three core central vestibular pathways, and examine the link between structural changes in these pathways and functional changes in clinical skills mediated by these pathways. Specifically, we aim to: Aim 1 Investigate the relationship between peripheral vestibular sensory loss associated with aging and the structure of central vestibular pathways, specifically considering 3 primary central vestibular pathways: 1) spatial cognitive; 2) sensorimotor; 3) prefrontal cortex (executive function). Aim 2 Examine the longitudinal relationships between peripheral vestibular loss and structural changes in central vestibular pathways using longitudinal models and also the novel change-point model in aging adults. Aim 3 Explore the association between structural changes in central vestibular pathways and clinical functional changes cross-sectionally and longitudinally. This proposal represents a unique opportunity to leverage strengths in vestibular physiology and computational neuroimaging to increase our fundamental understanding of the impact of healthy aging on central vestibular networks, and associated clinical consequences. Findings from this study will be used to drive further critical research questions, including 1) Does vestibular loss contribute to the accelerated decline in cognitive ability and brain structure that occurs in individuals with cognitive impairment and Alzheimer’s disease; and 2) Can vestibular interventions for vestibular loss prevent/mitigate changes in central vestibular pathways?

新兴的研究提供了令人信服的证据，表明前庭系统不仅对基本神经系统有贡献