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Neuroimaging Core

神经影像核心

基本信息

批准号：
10643946
负责人：
HENRY RUSINEK
金额：
$ 29.31万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10643946
关键词：
Aging Algorithms Alzheimer&apos s Disease Alzheimer&apos s disease model Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Amyloid Amyloid beta-Protein Anatomy Animal Model Archives Atrophic Autopsy Award Biological Markers Blood Vessels Brain Brain imaging Carbon Dioxide Classification Clinical Collaborations Computer software Consultations Databases Development Diagnosis Diagnostic Diffusion Early Diagnosis Early identification Faculty Funding Future Goals Hippocampus Human Human Resources Hydration status Hydrogen Image Image Analysis Imaging Device Imaging technology Impaired cognition Iron Kinetics Lesion Link Machine Learning Magnetic Resonance Imaging Measures Medial Metabolism Methods Modeling Molecular Nerve Degeneration Pathogenesis Pathologic Perfusion Positron-Emission Tomography Protocols documentation Protons Quality Control Recommendation Recovery Reference Values Research Research Personnel Research Project Grants Resources Risk Factors Scientist Sodium Specimen Standardization Techniques Technology Temporal Lobe Thick Training Translating United States National Institutes of Health Validation Work abeta accumulation abeta deposition aging brain animal imaging cerebrovascular clinical imaging clinically relevant data management deep learning design entorhinal cortex experience hippocampal atrophy image guided image reconstruction imaging approach imaging modality imaging study improved in vivo machine learning model metabolic rate neuroimaging neuropathology predictive modeling reconstruction tau Proteins uptake water diffusion white matter

项目摘要

ABSTRACT- NEUROIMAGING CORE Neuroimaging Core continues its support of NYU ADRC with standardized image acquisitions and the development of new imaging protocols. The Core has evolved as a significant world-wide resource of imaging tools and metrics to study brain aging and to translates image-based animal models of AD to human studies. The Core includes faculty experienced in structural and functional neuroimaging whose work led to multiple NIH-funded awards designed to both identify early risk factors and elucidate mechanisms of AD progression. The three specific aims are: 1) to assure standard, quality-controlled protocols and provide key brain measures for all subjects; 2) to develop and validate new imaging modalities/software to support the scientific themes of NYU ADRC; and 3) to provide imaging guidance and training. To achieve these goals we will introduce amyloid and tau PET imaging to augment existing MRI sequences. We will provide stringent quality control, compile normative reference values for all image-derived metrics, and provide the Neuropathology Core with in vivo and post mortem MRI to validate anatomical findings. The core will also devote significant effort to add machine learning models to diagnostic and processing workflows.

摘要-神经影像学核心