Core F: Neuroimaging Core

核心 F：神经影像核心

• 批准号: 9088208
• 负责人: HENRY RUSINEK
• 金额: $ 30.82万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9088208
• 关键词: Acids; Aging; Algorithms; Alzheimer' s Disease Core Center; Amyloid; Amyloid Proteins; Anatomy; Animal Model; Atrophic; Award; Biological Assay; Blood; Blood Vessels; Brain; Brain imaging; Carbon Dioxide; Clinical; Collaborations; Computer software; Consultations; Core-Binding Factor; Databases; Development; Diffusion; Disease; Early Diagnosis; Evaluation; Faculty; Funding; Growth; Hippocampal Formation; Hippocampus (Brain); Human; Human Resources; Image; Image Analysis; Imagery; Imaging Device; Imaging technology; Iron; Kinetics; Lesion; Magnetic Resonance Imaging; Measures; Metabolism; Microscopic; Modality; Modeling; Molecular; Participant; Pathology; Pathway interactions; Perfusion; Positron-Emission Tomography; Protocols documentation; Quality Control; Reference Values; Research Personnel; Resolution; Resources; Rest; Retrieval; Risk Factors; Scientist; Services; Site; Sodium; Staging; Techniques; Technology; Testing; Thick; Three-Dimensional Image; Translating; United States National Institutes of Health; Validation; abstracting; aging brain; animal imaging; base; candidate marker; cerebral atrophy; cerebrovascular; design; entorhinal cortex; experience; fluorodeoxyglucose positron emission tomography; hippocampal atrophy; imaging biomarker; imaging modality; in vivo; inflammatory marker; innovation; meetings; metabolic rate; neuroimaging; neuropathology; pre-clinical; standard measure; tau Proteins; tool; water diffusion; white matter

PROJECT SUMMARY/ABSTRACT NEUROIMAGING CORE Neuroimaging Core continues its full support of NYU ADC with standardized image acquisitions and the development of new imaging protocols. The Core also develops image analysis tools, generates standard measures, and translates image-based animal models of AD to human studies. The Core includes faculty experienced in the structural and functional analyses of human brain aging and AD. The Core enabled pioneering studies of hippocampal atrophy and hypometabolism. During the past cycle the Core successfully tested and implemented the transfer of all human brain imaging from the 1.5 T to 3T MRI. The Core implemented innovative imaging modalities that led to 19 new NIH awards designed to identify early risk factors and to elucidate mechanisms of AD progression. Consistent with the early detection theme of the ADC, we plan to advance imaging of brain water diffusion, to develop in vivo intracellular sodium and iron imaging, and to validate new kinetic PET models. The three specific aims are: 1) to assure standard, quality-controlled imaging protocols and measures; 2) to develop neuroimaging modalities and software; and 3) to provide guidance in designing new imaging projects.

项目总结/摘要 神经成像核心 Neuroimaging Core继续通过标准化图像采集和 开发新的成像协议。核心还开发图像分析工具，生成标准 测量，并将基于图像的AD动物模型转化为人类研究。核心包括教师 在人脑老化和AD的结构和功能分析方面经验丰富。核心启用 海马萎缩和代谢减退的开创性研究。在过去的周期中，核心成功地 测试并实现了所有人脑成像从1.5 T到3 T MRI的转移。核心 实施了创新的成像模式，导致19个新的NIH奖项，旨在识别早期风险 并阐明AD进展的机制。与ADC的早期检测主题一致， 我们计划推进脑水扩散成像，开发体内细胞内钠和铁成像， 并验证新的动力学PET模型。三个具体目标是：1）保证标准，质量受控 成像协议和措施; 2）开发神经成像模式和软件;以及3）提供 指导设计新的成像项目。