Neuroimaging Core

抽象神经成像核心 神经成像核心继续支持纽约大学ADRC通过标准化的图像采集和 开发新的成像协议。核心已经发展成为一个重要的全球成像资源 研究大脑老化的工具和指标，并将基于图像的阿尔茨海默病动物模型转化为人类研究。 核心包括在结构和功能神经成像方面经验丰富的教员，他们的工作导致了 NIH资助的奖项旨在识别早期风险因素和阐明AD进展的机制。 三个具体目标是：1)确保标准的、有质量控制的协议，并提供关键的脑部措施 针对所有对象；2)开发和验证新的成像模式/软件，以支持以下科学主题 纽约大学ADRC；以及3)提供成像指导和培训。为了实现这些目标，我们将引入淀粉样蛋白 和tau PET成像，以增强现有的MRI序列。我们将提供严格的质量控制，编制 所有图像衍生指标的标准化参考值，并为神经病理学核心提供活体 以及验尸后核磁共振以确认解剖发现。核心还将投入大量努力来增加 机器学习模型到诊断和处理工作流。

ABSTRACT- NEUROIMAGING CORE Neuroimaging Core continues its support of NYU ADRC with standardized image acquisitions and the development of new imaging protocols. The Core has evolved as a significant world-wide resource of imaging tools and metrics to study brain aging and to translates image-based animal models of AD to human studies. The Core includes faculty experienced in structural and functional neuroimaging whose work led to multiple NIH-funded awards designed to both identify early risk factors and elucidate mechanisms of AD progression. The three specific aims are: 1) to assure standard, quality-controlled protocols and provide key brain measures for all subjects; 2) to develop and validate new imaging modalities/software to support the scientific themes of NYU ADRC; and 3) to provide imaging guidance and training. To achieve these goals we will introduce amyloid and tau PET imaging to augment existing MRI sequences. We will provide stringent quality control, compile normative reference values for all image-derived metrics, and provide the Neuropathology Core with in vivo and post mortem MRI to validate anatomical findings. The core will also devote significant effort to add machine learning models to diagnostic and processing workflows.