PENN Vision Clinical Scientist Program

PENN Vision 临床科学家计划

• 批准号: 10643842
• 负责人: JOSHUA L DUNAIEF
• 金额: $ 49.62万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643842
• 关键词: Address; Applied Research; Area; Award; Basic Science; Bioethics; Clinical; Collaborations; Custom; Development; Doctor of Philosophy; Doctor' s Degree; Education; Educational Activities; Fellowship; Genetic; Grant; Health Services Research; Individual; Lead; Mentored Clinical Scientist Development Program; Mentors; Molecular Biology; Multi-Institutional Clinical Trial; Neurosciences; Ophthalmology; Productivity; Research; Research Activity; Research Personnel; Research Project Grants; Scientist; Time; Training; Translational Research; Universities; Vision; Vision research; clinical epidemiology; clinical training; design; experience; medical schools; patient oriented research; programs; skills

1. Project Summary / Abstract The Penn Vision Clinical Scientist Program (VCSP) is designed to prepare clinician scientists to identify and prioritize important questions in vision research, formulate a comprehensive approach to address the questions, and develop skills to effectively lead the efforts of a research team to provide answers. The (VCSP is centered in the Department of Ophthalmology, School of Medicine. Candidates for the VCSP hold a clinical doctoral degree (MD, PhD, DO, OD, DVM or equivalent) and have completed their clinical training, usually through the fellowship level. Scholars initially engage in educational and research activities to lay the groundwork for submission after 2 years of an application for an independent K08, K23, or R01. Scholars are supported on the K12 for up to 3 years, or until award of their individual grant, whichever comes first. Up to 2 scholars are supported on the K12 at any given time. The program takes advantage of established educational programs within the University, the concentration of strong basic science, translational research, and patient- oriented research programs ongoing within the Department of Ophthalmology, and the breadth of expertise available through Penn's interdisciplinary institutes and centers. Scholars have access to formal educational programs and applied research experiences in a vast array of areas such as clinical epidemiology, single-center and multi-center clinical trials, health services research, bioethics, genetics, molecular biology, and neuroscience. Established investigators in basic science, translational research, and patient-oriented research serve as mentors to guide choices by scholars in educational programs and research projects. The Penn VCSP has two defined tracks, translational research and patient oriented research. Each track has a didactic training component and a component of supervised research with increasing independence. However, the specific content of each program is custom built for each scholar. Each scholar has a primary mentor and a mentoring team to advise on the scientific aspects of their research and on activities necessary for professional development, collaboration among investigators, and developing long-term research programs. Upon completion of the program, scholars have received superb training to become productive and successful independent researchers.

1.项目摘要/摘要 宾夕法尼亚大学视觉临床科学家计划(VCSP)旨在为 临床医生科学家确定视觉研究中的重要问题并确定优先顺序， 制定一个全面的方法来解决这些问题，并培养技能以 有效地领导研究团队的努力，提供答案。 (VCSP中心设在医学院眼科。 VCSP的候选人拥有临床博士学位(MD、PhD、DO、OD、DVM或同等学历) 并已完成临床培训，通常是通过团契级别。学者们最初 参与教育和研究活动，为两年后提交奠定基础 独立的K08、K23或R01的应用程序。学者在K12上得到支持 至3年，或直至其个人拨款获颁为止，以较早者为准。最多2名学者 在任何给定的时间在K12上支持。 该计划利用了在 大学，专注于强大的基础科学，翻译研究，和耐心- 眼科内正在进行的定向研究计划，以及 通过宾夕法尼亚州立大学的跨学科研究所和中心提供的专业知识。学者们已经 获得大量正规教育项目和应用研究经验 临床流行病学、单中心和多中心临床试验、卫生 服务研究、生物伦理学、遗传学、分子生物学和神经科学。 在基础科学、转化性研究和以患者为导向方面的资深研究人员 研究充当导师，指导学者在教育项目中的选择 研究项目。 宾夕法尼亚大学VCSP有两个明确的轨道，即翻译研究和以患者为中心 研究。每条赛道都有一个教学训练部分和一个受监督的部分 研究的独立性越来越强。不过，每个节目的具体内容是 为每位学者量身定做。每位奖学金获得者都有一名主要导师和一支指导团队 就他们研究的科学方面和专业人员所需的活动提供建议 开发，研究人员之间的合作，以及开发长期研究计划。 在完成该计划后，学者们接受了精湛的培训，以变得富有成效 以及成功的独立研究人员。

项目成果

Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma.

• DOI: 10.3389/fncel.2023.1156829
• 发表时间: 2023
• 期刊: Frontiers in cellular neuroscience
• 影响因子: 5.3

Diagnostic and therapeutic challenges.

诊断和治疗的挑战。

• DOI: 10.1097/iae.0b013e3181a0bde9
• 发表时间: 2009
• 期刊: Retina (Philadelphia, Pa.)
• 作者: Yang,Sam;Borirakchanyavat,Sidhiporn;Chan-Kai,BrianT;Stout,JTimothy;Fu,ArthurD
• 通讯作者: Fu,ArthurD

Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization.

• DOI: 10.3109/13816810.2015.1126616
• 发表时间: 2016-12
• 期刊: Ophthalmic genetics
• 影响因子: 1.2
• 作者: Fuerst NM;Serrano L;Han G;Morgan JI;Maguire AM;Leroy BP;Kim BJ;Aleman TS
• 通讯作者: Aleman TS

Rhizopus keratitis following corneal trauma.

角膜外伤后的根霉菌性角膜炎。

• DOI: 10.1001/2013.jamaophthalmol.380
• 发表时间: 2013
• 期刊: JAMA ophthalmology
• 影响因子: 8.1
• 作者: Azari,AmirA;Nehls,Sarah;Ghoghawala,ShahedY;Lee,Vivian;Kanavi,MozhganR;Potter,HeatherD
• 通讯作者: Potter,HeatherD

Postnatal Serum Insulin-Like Growth Factor I and Retinopathy of Prematurity in Latin American Infants.

拉丁美洲婴儿产后血清胰岛素样生长因子 I 和早产儿视网膜病变。

• DOI: 10.1080/09286586.2020.1812090
• 发表时间: 2021
• 期刊: Ophthalmic epidemiology
• 影响因子: 1.8
• 作者: deAlbaCampomanes,AlejandraG;EspinozaNavarro,Judith;Shaffer,James;Ying,Gui-Shuang;Zepeda-Romero,LuzConsuelo;González-Bernal,Cesareo;Gutierrez-Padilla,JoséAlfonso;Schbib,VaninaLaura;Galan,MariaMarta;Binenbaum,Gil
• 通讯作者: Binenbaum,Gil