PENN Vision Clinical Scientist Program

PENN Vision 临床科学家计划

• 批准号: 10643842
• 负责人: JOSHUA L DUNAIEF
• 金额: $ 49.62万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643842
• 关键词: Address; Applied Research; Area; Award; Basic Science; Bioethics; Clinical; Collaborations; Custom; Development; Doctor of Philosophy; Doctor' s Degree; Education; Educational Activities; Fellowship; Genetic; Grant; Health Services Research; Individual; Lead; Mentored Clinical Scientist Development Program; Mentors; Molecular Biology; Multi-Institutional Clinical Trial; Neurosciences; Ophthalmology; Productivity; Research; Research Activity; Research Personnel; Research Project Grants; Scientist; Time; Training; Translational Research; Universities; Vision; Vision research; clinical epidemiology; clinical training; design; experience; medical schools; patient oriented research; programs; skills

1. Project Summary / Abstract The Penn Vision Clinical Scientist Program (VCSP) is designed to prepare clinician scientists to identify and prioritize important questions in vision research, formulate a comprehensive approach to address the questions, and develop skills to effectively lead the efforts of a research team to provide answers. The (VCSP is centered in the Department of Ophthalmology, School of Medicine. Candidates for the VCSP hold a clinical doctoral degree (MD, PhD, DO, OD, DVM or equivalent) and have completed their clinical training, usually through the fellowship level. Scholars initially engage in educational and research activities to lay the groundwork for submission after 2 years of an application for an independent K08, K23, or R01. Scholars are supported on the K12 for up to 3 years, or until award of their individual grant, whichever comes first. Up to 2 scholars are supported on the K12 at any given time. The program takes advantage of established educational programs within the University, the concentration of strong basic science, translational research, and patient- oriented research programs ongoing within the Department of Ophthalmology, and the breadth of expertise available through Penn's interdisciplinary institutes and centers. Scholars have access to formal educational programs and applied research experiences in a vast array of areas such as clinical epidemiology, single-center and multi-center clinical trials, health services research, bioethics, genetics, molecular biology, and neuroscience. Established investigators in basic science, translational research, and patient-oriented research serve as mentors to guide choices by scholars in educational programs and research projects. The Penn VCSP has two defined tracks, translational research and patient oriented research. Each track has a didactic training component and a component of supervised research with increasing independence. However, the specific content of each program is custom built for each scholar. Each scholar has a primary mentor and a mentoring team to advise on the scientific aspects of their research and on activities necessary for professional development, collaboration among investigators, and developing long-term research programs. Upon completion of the program, scholars have received superb training to become productive and successful independent researchers.

1.项目总结/摘要 Penn Vision临床科学家计划（VCSP）旨在准备 临床科学家识别和优先考虑视觉研究中的重要问题， 制定解决问题的全面方法，并培养技能， 有效地领导研究团队提供答案的努力。 VCSP以医学院眼科学系为中心。 VCSP的候选人持有临床博士学位（MD，PhD，DO，OD，DVM或同等学历） 并完成了临床培训，通常是通过奖学金水平。学者最初 参与教育和研究活动，为2年后提交奠定基础 申请独立的K 08、K23或R 01。学者在K12上获得支持， 至3年，或直至获发个别助学金为止，以较早者为准。最多2名学者 在任何时候都支持K12。 该计划利用了建立在教育计划的优势， 大学，强大的基础科学，转化研究和病人的浓度- 眼科学系正在进行的面向研究项目，以及 通过宾夕法尼亚大学的跨学科研究所和中心提供的专业知识。学者 获得正式的教育计划和应用研究经验，在一个广阔的阵列 临床流行病学、单中心和多中心临床试验、健康等领域 服务研究、生物伦理学、遗传学、分子生物学和神经科学。 在基础科学、转化研究和以患者为导向方面建立了研究者 研究作为导师，指导学者在教育方案中的选择， 研究项目。 宾夕法尼亚大学VCSP有两个明确的轨道，转化研究和患者导向 research.每个轨道都有一个教学培训部分和一个监督的组成部分， 研究越来越独立。不过，每项计划的具体内容， 为每一位学者量身打造。每个学者都有一个主要的导师和一个指导团队， 就其研究的科学方面以及专业人员开展必要活动提供咨询意见 发展，研究人员之间的合作，以及制定长期的研究计划。 在完成该计划后，学者们接受了高超的培训，成为生产力 成功的独立研究人员。

项目成果

Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma.

• DOI: 10.3389/fncel.2023.1156829
• 发表时间: 2023
• 期刊: Frontiers in cellular neuroscience
• 影响因子: 5.3

Diagnostic and therapeutic challenges.

诊断和治疗的挑战。

• DOI: 10.1097/iae.0b013e3181a0bde9
• 发表时间: 2009
• 期刊: Retina (Philadelphia, Pa.)
• 作者: Yang,Sam;Borirakchanyavat,Sidhiporn;Chan-Kai,BrianT;Stout,JTimothy;Fu,ArthurD
• 通讯作者: Fu,ArthurD

Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization.

• DOI: 10.3109/13816810.2015.1126616
• 发表时间: 2016-12
• 期刊: Ophthalmic genetics
• 影响因子: 1.2
• 作者: Fuerst NM;Serrano L;Han G;Morgan JI;Maguire AM;Leroy BP;Kim BJ;Aleman TS
• 通讯作者: Aleman TS

Rhizopus keratitis following corneal trauma.

角膜外伤后的根霉菌性角膜炎。

• DOI: 10.1001/2013.jamaophthalmol.380
• 发表时间: 2013
• 期刊: JAMA ophthalmology
• 影响因子: 8.1
• 作者: Azari,AmirA;Nehls,Sarah;Ghoghawala,ShahedY;Lee,Vivian;Kanavi,MozhganR;Potter,HeatherD
• 通讯作者: Potter,HeatherD

Postnatal Serum Insulin-Like Growth Factor I and Retinopathy of Prematurity in Latin American Infants.

拉丁美洲婴儿产后血清胰岛素样生长因子 I 和早产儿视网膜病变。

• DOI: 10.1080/09286586.2020.1812090
• 发表时间: 2021
• 期刊: Ophthalmic epidemiology
• 影响因子: 1.8
• 作者: deAlbaCampomanes,AlejandraG;EspinozaNavarro,Judith;Shaffer,James;Ying,Gui-Shuang;Zepeda-Romero,LuzConsuelo;González-Bernal,Cesareo;Gutierrez-Padilla,JoséAlfonso;Schbib,VaninaLaura;Galan,MariaMarta;Binenbaum,Gil
• 通讯作者: Binenbaum,Gil