Evaluating Sleep Deficiency in Aging Populations

评估老龄化人群的睡眠不足

• 批准号: 10646363
• 负责人: BRIENNE MINER
• 金额: $ 23.72万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646363
• 关键词: Academy; Address; Adverse effects; Age; Aging; American; Assessment tool; Award; Awareness; Capsicum; Data; Detection; Development; Device or Instrument Development; Diagnosis; Drowsiness; Elderly; Electroencephalography; Environment; Etiology; Foundations; Future; Geriatrics; Gills; Goals; Grant; Health; Home environment; Hypersomnias; Impaired cognition; Impairment; Institutionalization; International; Intervention; Interview; K-Series Research Career Programs; Laboratories; Measures; Medicine; Mentors; Methods; Minority Groups; Morbidity - disease rate; Nature; Nocturia; Normal Range; Outcome; Patient Self-Report; Perception; Persons; Phase; Physical Performance; Physicians; Polysomnography; Population; Publications; Qualitative Methods; Questionnaires; Reference Standards; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Schedule; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Societies; Specialist; Symptoms; Testing; Training Programs; United States National Institutes of Health; Universities; Work; actigraphy; adverse outcome; career; career development; circadian biology; clinical epidemiology; clinical training; cohort; epidemiology study; expectation; experience; flexibility; functional decline; functional disability; improved; improvement on sleep; instrument; leadership development; medical schools; mortality; novel; pilot test; poor sleep; prevent; programs; research and development; response; screening; sleep health; sleep quality; standard measure; success; therapeutic target; tool; training opportunity; vigilance

PROJECT SUMMARY/ABSTRACT Candidate: My career goal is to become an independent clinician-investigator focused on improving sleep- wake disturbances and preventing their adverse outcomes in older persons. My clinical training as a Geriatrics and Sleep Medicine physician and research training in Geriatric Clinical Epidemiology form the foundation on which I will build to reach this goal. My track record of success is evidenced by the publication of high-impact original reports and the receipt of 3 grants. I have distinguished myself as a national leader and received awards for my research from the Sleep Research Society, the American Academy of Sleep Medicine (AASM), and the American Geriatrics Society (AGS), including the AGS New Investigator Award and a career development award from the AASM Foundation. Mentors and Environment: I have an outstanding team of mentors and advisors, including my primary mentor, Dr. Thomas Gill (Geriatrics), an internationally recognized thought leader in aging research, and co- mentor Dr. Klar Yaggi (Sleep Medicine), an expert in conducting epidemiologic studies aimed at understanding the health outcomes of sleep disorders. I also have a team of advisors, selected based on their expertise in aging, sleep, qualitative and mixed-methods research, circadian biology and analysis, and instrument development. I have outlined a rigorous program of training that draws upon the wealth of resources across Yale University, including the Program on Aging/Claude D. Pepper Older Americans Independence Center, as well as national training opportunities in mixed methods research and leadership development. These resources, and the support of the Sections of Geriatrics and Sleep Medicine at the Yale School of Medicine, provide an ideal environment for my career development and execution of the proposed research. Mentored Research Project: Sleep-wake disturbances are associated with important adverse outcomes in older persons, including cognitive and functional decline. Our prior work has demonstrated that these disturbances are under-diagnosed in older persons, which may be due to the poor sensitivity of existing sleep questionnaires, the frequent co-occurrence of multiple sleep-wake disturbances, and the burdensome nature of objective sleep testing. We propose to develop and test age-appropriate, comprehensive subjective and objective sleep assessment tools to facilitate identification of older persons with sleep-wake disturbances. To accomplish this, we will assess sleep-wake disturbances using a broader construct termed, “sleep deficiency”, which is a condition causing functional impairment as a result of a deficit in sleep quality, sleep duration, and/or sleep that is out-of-sync with the body's natural clock (i.e., non-circadian sleep). The overall objective is to develop and pilot test tools to identify sleep deficiency in older persons. Future work will validate these tools, which can be used to target interventions to improve sleep health and prevent adverse outcomes.

项目摘要/摘要 候选人：我的职业目标是成为一名专注于改善睡眠的独立临床评估者 唤醒灾难并防止老年人的不良结果。我的临床培训作为老年医学 和睡眠医学老年临床流行病学的物理和研究培训构成了基础 我将建立该目标。我的成功记录可以通过高影响力的出版来证明 原始报告和3个补助金的收据。我以国家领导人的身份出名 我从睡眠研究学会，美国睡眠医学学会（AASM）的研究奖项， 以及美国老年医学学会（AGS），包括AGS新调查员奖和职业 AASM基金会的发展奖。 导师和环境：我有一个杰出的导师和顾问团队，包括我的主要团队 导师托马斯·吉尔（Thomas Gill）博士（老年医学）是国际认可的衰老研究思想领导者，并共同 导师Klar Yaggi博士（睡眠医学），旨在理解的流行病学研究专家 睡眠障碍的健康结果。我还有一个顾问团队，根据他们的专业知识选择 衰老，睡眠，定性和混合方法研究，昼夜生物学和分析以及仪器 发展。我概述了一个严格的培训计划，该计划利用了整个资源的财富 耶鲁大学，包括有关老龄化/克劳德·D·佩珀老年美国人独立中心的计划， 以及混合方法研究和领导力发展中的国家培训机会。这些 资源，以及耶鲁大学医学院老年医学和睡眠医学部分的支持， 为我的职业发展和拟议研究的执行提供理想的环境。 指导的研究项目：睡眠效果与重要的不良后果有关 老年人，包括认知和功能下降。我们先前的工作证明了这些 在老年人中，疾病的诊断不足，这可能是由于现有睡眠的敏感性不佳 问卷，多次睡眠灾难的经常发生的同时发生以及负担的性质 客观睡眠测试。我们建议开发和测试适合年龄的，全面的主观和 客观的睡眠评估工具，以促进识别睡眠障碍的老年人。 为此，我们将使用更广泛的结构来评估睡眠觉醒的灾难，“睡眠 不足”，这是由于睡眠质量不足而导致功能障碍的条件 持续时间和/或睡眠与人体的自然时钟（即非circadian睡眠）不同步。总体 目的是开发和试点测试工具，以识别老年人的睡眠不足。未来的工作将验证 这些工具可用于针对干预措施，以改善睡眠健康并防止不良后果。