Interdisciplinary Mentoring and Research in Womens Cardiovascular Health

女性心血管健康的跨学科指导和研究

• 批准号: 10646432
• 负责人: REBECCA C THURSTON
• 金额: $ 11.16万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646432
• 关键词: Acceleration; Accounting; Address; Aging; Anxiety; Apnea; Area; Award; Benign; Biological Aging; Blood Vessels; Cardiovascular Diseases; Cardiovascular Manifestation; Cardiovascular system; Carotid Atherosclerotic Disease; Cause of Death; Cessation of life; Characteristics; Coronary; DNA Methylation; Development; Disease Progression; Dose; Epigenetic Process; Funding; Future; Goals; Gonadal Steroid Hormones; Hormonal; Hot flushes; Inflammation; Inflammatory; Interleukin-6; Intervention; Investigation; Knowledge; Link; Measures; Mediation; Menopausal Symptom; Menopause; Mentors; Mentorship; Methods; Midcareer Investigator Award in Patient-Oriented Research; Moods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Night Sweating; Pathway interactions; Pattern; Phase; Physiologic pulse; Physiological; Play; Premenopause; Protocols documentation; Public Health; Reproductive History; Research; Research Personnel; Research Support; Resources; Risk; Risk Factors; Role; Scientist; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Symptoms; Testing; Time; Training; Training Support; United States National Institutes of Health; Venous blood sampling; Woman; Women' s Health; Work; advanced analytics; age related; cardiovascular disorder risk; cardiovascular health; career; career development; cerebrovascular; cytokine; heart rate variability; inflammatory marker; innovation; insight; intimal medial thickening; men; middle age; mortality risk; next generation; novel; novel marker; patient oriented research; poor sleep; prevent; programs; reproductive; response; sex; sleep quality; synergism; vasomotor symptoms

Cardiovascular disease (CVD) is the leading cause of death among women. Researchers and clinicians that can work across disciplinary boundaries are needed to effectively understand, prevent, and reduce the burden of CVD. A focus on women and CVD is critical given the multiple sex-specific risk factors for and manifestations of CVD that remain incompletely understood. This renewal application for an NHLBI Mid-Career Investigator Award in Patient-Oriented Research seeks support for Dr. Rebecca Thurston, an investigator with a strong track record in interdisciplinary mentoring, training, and research in midlife women's cardiovascular health. The specific aims of this Project are to provide Dr. Thurston with the training, resources, and protected time to strengthen and amplify the public health impact of her NIH-supported research program by: (1) providing outstanding mentorship and support for young investigators from diverse fields to address questions of critical importance to women's cardiovascular health; (2) supporting training for Dr. Thurston and her trainees in (a) advanced analytic mediation methods and (b) select physiologic mechanisms (inflammation, epigenetics) highly relevant to the development of CVD in women; and (3) to leverage ongoing NIH RF1- supported research and to build upon the first phase of K24-supported research that demonstrated critical cross-sectional relations of menopausal symptoms (sleep problems, vasomotor symptoms) to carotid atherosclerosis midlife women, relations not explained by traditional CVD risk factors or by sex hormones. We will now (a) investigate how persistence of menopausal symptoms over time relate to carotid atherosclerosis and its progression and (b) consider key novel mechanistic (inflammatory, epigenetic) pathways that may critically link menopausal symptoms to CVD risk in women. Proposed mentoring and career development activities are highly integrated, with the mutually reinforcing goals of advancing trainee careers and enhancing Dr. Thurston's burgeoning program of research and training in women's cardiovascular health.

心血管疾病是妇女死亡的主要原因。研究人员和临床医生， 能够跨越学科界限工作，以有效地了解，预防和减轻负担 的CVD。关注女性和心血管疾病是至关重要的，因为有多种性别特异性风险因素， 心血管疾病的表现仍然不完全了解。NHLBI中期职业生涯的续签申请 以患者为导向的研究的研究者奖寻求对Rebecca Thurston博士的支持，Rebecca Thurston博士是一名研究者， 在中年女性心血管疾病的跨学科指导，培训和研究方面有着良好的记录 健康该项目的具体目标是为Thurston博士提供培训，资源和保护 时间来加强和扩大她的NIH支持的研究计划的公共卫生影响：（1） 为来自不同领域的年轻调查人员提供出色的指导和支持，以解决问题 对妇女的心血管健康至关重要;（2）支持Thurston博士和她的培训 受训者（a）高级分析调解方法和（B）选择生理机制（炎症， 表观遗传学）与女性CVD的发展高度相关;（3）利用正在进行的NIH RF 1- 支持的研究，并建立在第一阶段的K24支持的研究，证明关键 绝经期症状（睡眠问题，血管紧张症状）与颈动脉 动脉粥样硬化中年妇女，传统的CVD危险因素或性激素不能解释的关系。我们 现在将（a）研究绝经期症状随时间的持续与颈动脉粥样硬化的关系 及其进展，以及（B）考虑可能 绝经期症状与女性CVD风险密切相关。拟议的辅导和职业发展 活动高度整合，目标是促进受训者的职业发展， 博士瑟斯顿在妇女心血管健康方面的研究和培训项目正在蓬勃发展。

项目成果

Menopausal Hot Flashes and Carotid Intima Media Thickness Among Midlife Women.

• DOI: 10.1161/strokeaha.116.014674
• 发表时间: 2016-12
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Thurston RC;Chang Y;Barinas-Mitchell E;Jennings JR;Landsittel DP;Santoro N;von Känel R;Matthews KA
• 通讯作者: Matthews KA

Hot flashes and awakenings among midlife women.

中年女性的潮热和觉醒。

• DOI: 10.1093/sleep/zsz131
• 发表时间: 2019
• 期刊: Sleep
• 影响因子: 5.6
• 作者: Thurston,RebeccaC;Chang,Yuefang;Buysse,DanielJ;Hall,MarticaH;Matthews,KarenA
• 通讯作者: Matthews,KarenA

Changes in heart rate variability during vasomotor symptoms among midlife women.

• DOI: 10.1097/gme.0000000000000586
• 发表时间: 2016-05
• 期刊: Menopause (New York, N.Y.)
• 作者: Thurston RC;Matthews KA;Chang Y;Santoro N;Barinas-Mitchell E;von Känel R;Landsittel DP;Jennings JR
• 通讯作者: Jennings JR

Patient-Centered Outcomes and Treatment Preferences Regarding Sexual Problems: A Qualitative Study Among Midlife Women.

关于性问题的以患者为中心的结果和治疗偏好：中年女性的定性研究。

• DOI: 10.1016/j.jsxm.2017.05.014
• 发表时间: 2017
• 期刊: The journal of sexual medicine
• 作者: Thomas,HollyN;Hamm,Megan;Hess,Rachel;Borrero,Sonya;Thurston,RebeccaC
• 通讯作者: Thurston,RebeccaC

Child Abuse and Neglect and Subclinical Cardiovascular Disease Among Midlife Women.

• DOI: 10.1097/psy.0000000000000400
• 发表时间: 2017-05
• 期刊: Psychosomatic medicine
• 影响因子: 3.3
• 作者: Thurston RC;Chang Y;Barinas-Mitchell E;von Känel R;Jennings JR;Santoro N;Landsittel DP;Matthews KA
• 通讯作者: Matthews KA