Interdisciplinary Mentoring and Research in Womens Cardiovascular Health

女性心血管健康的跨学科指导和研究

• 批准号: 8913258
• 负责人: REBECCA C THURSTON
• 金额: $ 9.51万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8913258
• 关键词: Acute; Address; Award; Behavior; Behavioral Medicine; Benign; Biological Rhythm; Blood; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Circadian Rhythms; Collection; Complex; Data; Development; Discipline; Disease; Disease Outcome; Distress; Electrocardiogram; Epidemiology; Event; Frequencies; Funding; Future; Goals; Health; Hot flushes; Hour; Human; Impedance Cardiography; Inflammatory; Insulin Resistance; Intervention; Life; Link; Lipids; Measures; Medical; Medicine; Menopause; Mentors; Mentorship; Methods; Midcareer Investigator Award in Patient-Oriented Research; Modeling; Monitor; Moods; N.I.H. Research Support; National Heart, Lung, and Blood Institute; Nature; Obesity; Pathway interactions; Perimenopause; Physiological; Physiology; Play; Population Study; Positioning Attribute; Postmenopause; Protocols documentation; Psychology; Public Health; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Role; Seminal; Series; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Stream; Symptoms; Testing; Time; Training; Training Support; Vasomotor; Woman; Women' s Health; Work; actigraphy; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; career; career development; diaries; endothelial dysfunction; hormone therapy; inflammatory marker; middle age; mortality; next generation; novel; patient oriented research; programs; reproductive; reproductive hormone; vascular sonography

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of death among women. Complex diseases such as CVD are multifactorial in origin, with their causes and sequelae spanning multiple scientific and medical disciplines. Researchers and clinicians that can work across disciplinary boundaries are needed to effectively understand and reduce the burden of CVD in women. This application for an NHLBI Mid-Career Investigator Award in Patient-Oriented Research seeks support for Dr. Rebecca Thurston, a mid-career investigator with a strong track record in interdisciplinary mentoring, training, and research in midlife women's cardiovascular health. The specific aims of this Project are to provide Dr. Thurston with the training, resources, and protected time to strengthen and amplify the public health impact of her NIH-supported research program by: (1) providing outstanding mentorship and support for young investigators from the fields of behavioral medicine, psychology, epidemiology, and medicine to address issues of importance to women's cardiovascular health; (2) supporting training for Dr. Thurston in interdisciplinary mentoring, sleep research methods, and advanced time-series methods; and (3) support extension of the aims of an ongoing NHLBI R01-supported research project testing the relation between menopausal hot flashes and cardiovascular risk to: a) investigate the role of sleep in these associations and to b) utilize th multiple streams of ambulatory time series data collected in this protocol to more innovatively model the dynamics of human physiology and behavior. The mentoring and career development activities are highly integrated, with the mutually reinforcing goals of advancing trainee careers and enhancing Dr. Thurston's growing program of research in women's cardiovascular health.

描述（由申请人提供）：心血管疾病（CVD）是妇女死亡的主要原因。复杂的疾病，如心血管疾病是多因素的起源，其原因和后遗症跨越多个科学和医学学科。研究人员和临床医生需要跨越学科界限，有效地了解和减轻妇女心血管疾病的负担。这个申请NHLBI中期职业研究者奖在面向患者的研究中寻求Rebecca Thurston博士的支持，她是一名中期职业研究者，在中年妇女心血管健康的跨学科指导、培训和研究方面有着良好的记录。该项目的具体目的是为瑟斯顿博士提供培训、资源和保护时间，以加强和扩大她在美国国立卫生研究院支持的研究项目对公共卫生的影响：(1)为来自行为医学、心理学、流行病学和医学领域的年轻研究者提供杰出的指导和支持，以解决对女性心血管健康的重要问题；(2)支持Thurston博士在跨学科指导、睡眠研究方法和先进的时间序列方法方面的培训；(3)支持扩展正在进行的NHLBI r01支持的研究项目的目标，测试更年期潮热与心血管风险之间的关系，以：a)调查睡眠在这些关联中的作用；b)利用本协议收集的多个流动时间序列数据流，更创新地模拟人类生理和行为的动态。指导和职业发展活动是高度整合的，相互促进的目标是促进学员的职业发展和加强瑟斯顿博士在女性心血管健康方面不断增长的研究项目。