Interdisciplinary Mentoring and Research in Womens Cardiovascular Health

描述(申请人提供)：心血管疾病(CVD)是导致女性死亡的主要原因。心血管疾病等复杂疾病的成因是多因素的，其原因和后遗症跨越多个科学和医学学科。需要能够跨学科工作的研究人员和临床医生，以有效地了解和减轻女性心血管疾病的负担。本次申请NHLBI以患者为中心的研究的职业中期研究员奖旨在为丽贝卡·瑟斯顿博士提供支持，她是一名职业中期的研究员，在中年女性心血管健康的跨学科指导、培训和研究方面有着良好的记录。这个项目的具体目的是为瑟斯顿博士提供培训、资源和有保障的时间，以加强和放大她的NIH支持的研究项目对公共健康的影响：(1)为来自行为医学、心理学、流行病学和医学领域的年轻研究人员提供杰出的指导和支持，以解决对女性心血管健康重要的问题；(2)支持瑟斯顿博士在跨学科指导、睡眠研究方法和高级时间序列方法方面的培训；以及(3)支持扩展正在进行的NHLBI R01支持的研究项目的目标，该研究项目测试更年期潮热和心血管风险之间的关系：a)调查睡眠在这些关联中的作用，b)利用本协议中收集的多个流动时间序列数据流，更具创新性地模拟人类生理和行为的动态。指导和职业发展活动是高度整合的，具有相辅相成的目标，即促进实习生的职业生涯，并加强瑟斯顿博士日益增长的女性心血管健康研究计划。

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of death among women. Complex diseases such as CVD are multifactorial in origin, with their causes and sequelae spanning multiple scientific and medical disciplines. Researchers and clinicians that can work across disciplinary boundaries are needed to effectively understand and reduce the burden of CVD in women. This application for an NHLBI Mid-Career Investigator Award in Patient-Oriented Research seeks support for Dr. Rebecca Thurston, a mid-career investigator with a strong track record in interdisciplinary mentoring, training, and research in midlife women's cardiovascular health. The specific aims of this Project are to provide Dr. Thurston with the training, resources, and protected time to strengthen and amplify the public health impact of her NIH-supported research program by: (1) providing outstanding mentorship and support for young investigators from the fields of behavioral medicine, psychology, epidemiology, and medicine to address issues of importance to women's cardiovascular health; (2) supporting training for Dr. Thurston in interdisciplinary mentoring, sleep research methods, and advanced time-series methods; and (3) support extension of the aims of an ongoing NHLBI R01-supported research project testing the relation between menopausal hot flashes and cardiovascular risk to: a) investigate the role of sleep in these associations and to b) utilize th multiple streams of ambulatory time series data collected in this protocol to more innovatively model the dynamics of human physiology and behavior. The mentoring and career development activities are highly integrated, with the mutually reinforcing goals of advancing trainee careers and enhancing Dr. Thurston's growing program of research in women's cardiovascular health.