Interdisciplinary Mentoring and Research in Womens Cardiovascular Health

描述（由申请人提供）：心血管疾病（CVD）是女性死亡的主要原因。复杂的疾病，如心血管疾病是多因素的起源，其原因和后遗症跨越多个科学和医学学科。需要能够跨越学科界限的研究人员和临床医生来有效地了解和减轻女性CVD的负担。Rebecca Thurston博士是一名职业中期调查员，在中年女性心血管健康的跨学科指导，培训和研究方面有着良好的记录。该项目的具体目标是为Thurston博士提供培训、资源和受保护的时间，以加强和扩大她的NIH支持的研究项目对公共卫生的影响：（1）为来自行为医学、心理学、流行病学和医学领域的年轻研究人员提供出色的指导和支持，以解决对妇女心血管健康重要的问题;（2）支持Thurston博士在跨学科指导，睡眠研究方法和先进的时间序列方法方面的培训;（3）支持正在进行的NHLBI R 01支持的研究项目的目标扩展，该项目旨在测试更年期潮热与心血管风险之间的关系：a）研究睡眠在这些关联中的作用，以及B）利用在该方案中收集的多个流动时间序列数据流来更创新地对人类生理和行为的动力学进行建模。指导和职业发展活动是高度整合的，具有相互促进的目标，即促进受训者的职业发展，并加强瑟斯顿博士在妇女心血管健康方面不断增长的研究计划。

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of death among women. Complex diseases such as CVD are multifactorial in origin, with their causes and sequelae spanning multiple scientific and medical disciplines. Researchers and clinicians that can work across disciplinary boundaries are needed to effectively understand and reduce the burden of CVD in women. This application for an NHLBI Mid-Career Investigator Award in Patient-Oriented Research seeks support for Dr. Rebecca Thurston, a mid-career investigator with a strong track record in interdisciplinary mentoring, training, and research in midlife women's cardiovascular health. The specific aims of this Project are to provide Dr. Thurston with the training, resources, and protected time to strengthen and amplify the public health impact of her NIH-supported research program by: (1) providing outstanding mentorship and support for young investigators from the fields of behavioral medicine, psychology, epidemiology, and medicine to address issues of importance to women's cardiovascular health; (2) supporting training for Dr. Thurston in interdisciplinary mentoring, sleep research methods, and advanced time-series methods; and (3) support extension of the aims of an ongoing NHLBI R01-supported research project testing the relation between menopausal hot flashes and cardiovascular risk to: a) investigate the role of sleep in these associations and to b) utilize th multiple streams of ambulatory time series data collected in this protocol to more innovatively model the dynamics of human physiology and behavior. The mentoring and career development activities are highly integrated, with the mutually reinforcing goals of advancing trainee careers and enhancing Dr. Thurston's growing program of research in women's cardiovascular health.