Predictive Markers for Longitudinal TMJ Integrity

纵向颞下颌关节完整性的预测标记

• 批准号: 10648171
• 负责人: YOLY M GONZALEZ-STUCKER
• 金额: $ 17.99万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-05 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648171
• 关键词: Address; Affect; American; Anatomy; Animal Model; Area; Arithmetic; Behavior; Biological Markers; Cephalic; Characteristics; Clinical; Consensus; Data; Data Set; Degenerative Disorder; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease Progression; Engineering; Environment; Failure; Fatigue; Female; Frequencies; Goals; Head; Health; High Prevalence; Hip region structure; Human; Image; Individual; Jaw; Joints; Knee; Length; Mandibular Condyle; Measurement; Measures; Mechanics; Medicine; Morphology; Muscle; National Institute of Dental and Craniofacial Research; Nickel; Occlusal Planes; Outcome; Pain; Patients; Pilot Projects; Predisposition; Psychophysiology; Publishing; Questionnaires; Reporting; Research; Risk; Risk Factors; Same-sex; Sex Differences; Structure; TMJ disk displacement; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; Time; Tissues; Translations; United States National Academy of Sciences; Work; articular cartilage; clinical practice; clinical translation; cohort; cone-beam computed tomography; cost; energy density; improved; joint loading; male; predictive marker; premature; tool

Project Summary/Abstract Temporomandibular disorders (TMDs) are prevalent, with estimates of 5% to 10%, with two-fold higher prevalence for females than males (NASEM, 2020), and projected annual costs of $4 billion (Stowell et al. 2007). TMD represents a group of conditions with and without pain, such as temporomandibular joint (TMJ) disc displacement and degenerative disease. Osseous changes are late-stage, degenerative characteristics (Farina et al. 2009; Luder 2002; Wiese et al. 2008) that tend to occur >10 years earlier in the TMJ than in other human joints. The long-term goals are to elucidate the variables responsible for precocious TMJ tissue failure and the predilection for females compared to males. TMJ tissue fatigue depends on applied mechanics and behavior; that is, magnitudes and frequencies of energy input to tissues. Published and preliminary data show that magnitudes and frequencies of energy input to TMJ tissues, quantified by Mechanobehavior Score (MBS, mJ∙%/mm3), predict longitudinal changes in TMJ structures. It was found that in 35 subjects over ≥5.3 years, TMJs where intracapsular diagnoses worsened had average MBS 8-times and 3-times greater than TMJs where diagnoses improved and remained stable, respectively. However, there are anatomical and psychophysiological variables that are more easily measured and clinically translatable. The Anatomic- Psychophysiologic Score (APS), the arithmetic product of these measures, correlated well with MBS. Therefore, the overall objective is to use an existing landmark data set from the TMJ Impact Project (Schiffman et al. 2017) to evaluate these markers (APS) to predict longitudinal changes in TMJ structures and intracapsular diagnoses over 8 years in 401 subjects (789 TMJs). The specific aims are to: (1) Determine if easily measured anatomical and psychophysiological variables predict conversion rate and direction of changes to TMJ structures associated with changes in intracapsular diagnoses, and if there are sex differences. (2) Test for sex differences in longitudinal changes in mandibular condyle volume within and between diagnostic groups. The outcomes of these specific aims will help to address the current needs identified by the National Academies of Sciences, Engineering, and Medicine 2020 consensus report for "new tools, metrics, and biomarkers to diagnose TMD and forecast their trajectory.”

项目摘要/摘要 颞下颌关节紊乱病(TMD)很普遍，估计有5%到10%，高出两倍 女性患病率高于男性(Nasem，2020)，预计每年成本为40亿美元(Stowell等人)。 2007)。TMD代表了一组有痛和无痛的情况，如TMJ 椎间盘移位和退行性疾病。骨性改变是晚期退行性改变的特征。 (Farina等人)2009年；Luder 2002；Wiese等人。2008)，这往往比其他地区早10年出现在TMJ 人体关节。长期目标是阐明导致TMJ早熟组织衰竭的变量 与男性相比，女性的偏好更高。TMJ组织疲劳依赖于应用力学和 行为；即，输入到组织的能量的大小和频率。公布的和初步的数据显示 输入到TMJ组织的能量的大小和频率由机械行为评分(MBS， MJ∙%/mm~3)，预测TMJ结构的纵向变化。研究发现，在≥5.3年的35名受试者中， 囊内诊断恶化的TMJ的平均MB分别是TMJ的8倍和3倍 在诊断有所改善和保持稳定的情况下。然而，有解剖学和 更容易测量和临床可翻译的心理生理变量。解剖学-- 心理生理学评分(APS)是这些测量的算术积，与MBS有很好的相关性。 因此，总体目标是使用TMJ Impact Project(希夫曼)现有的里程碑式数据集 等人的研究。2017)评估这些标记(AP)以预测TMJ结构和 囊腔内诊断401例(789个TMJ)超过8年。具体目标是： (1)确定容易测量的解剖学和心理生理学变量是否可以预测转化率和 与囊内诊断改变相关的TMJ结构改变的方向，以及是否有 性别差异。 (2)下颌骨髁突体积纵向变化的性别差异检验 诊断组。 这些具体目标的成果将有助于满足国家发展基金确定的当前需求 科学院、工程院和医学科学院2020年共识报告 用于诊断TMD并预测其轨迹的生物标记物。