Daily Ovarian Hormone Exposure and Loss of Control Eating in Adolescent Girls: A Within-Day RDoC Study

青春期女孩每日卵巢激素暴露和饮食失控：一项日内 RDoC 研究

• 批准号: 10649510
• 负责人: Tyler Mason
• 金额: $ 24.75万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-20 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10649510
• 关键词: Adolescence; Adolescent; Adult; Affect; Behavior Disorders; Binge eating disorder; Biological Factors; Brain region; Bulimia; Cellular Phone; Childhood; Development; Disease; Eating; Eating Behavior; Eating Disorders; Ecological momentary assessment; Estrogens; Etiology; Exposure to; Female; Female Adolescents; Future; Goals; Hormonal; Hormones; Intervention; Link; Maintenance; Measures; Mediating; Mediation; Menarche; Menstrual cycle; Mental Health; Modeling; Morbidity - disease rate; Neurocognitive; Ovarian hormone; Patient Self-Report; Pattern; Persons; Phase; Precipitating Factors; Prevention; Process; Progesterone; Puberty; Public Health; Quality of life; Reporting; Research; Research Domain Criteria; Rewards; Risk; Risk Factors; Role; Sampling; Severities; Surveys; Syndrome; Targeted Research; Testosterone; Variant; Woman; Work; Youth; aged; biobehavior; boys; emotional eating; executive function; experience; girls; health care service utilization; high reward; loss of control over eating; mortality; novel; response; reward anticipation; risk prediction; saliva sample; sex

PROJECT SUMMARY/ABSTRACT In adolescent girls, loss of control (LOC) eating is a maladaptive eating behavior associated with psychiatric morbidity, including the development of full syndrome eating disorders. However, the daily biobehavioral factors that precipitate LOC eating are not well known. Ovarian hormone levels are key biological factors associated with the etiology of eating disorders in adolescent girls. Yet, models on how daily ovarian hormone exposure predicts LOC eating in adolescent girls are underdeveloped. Two relevant research domain criteria (RDoC) implicated in eating disorders include reward anticipation and response inhibition. These processes associate with variations in ovarian hormone levels, and thus, daily hormone exposure may cause dysregulation in reward anticipation and response inhibition, which may in turn precipitate LOC eating. Given the substantial gap in research on daily hormone exposure and LOC eating in adolescent girls including momentary mediating mechanisms, the goal of this study is to examine the patterns and mechanisms of ovarian hormone exposure on LOC eating across the menstrual cycle in adolescent girls. Ecological momentary assessment (EMA) paired with daily hormonal sampling will be used to examine daily and momentary associations between daily hormone exposure and LOC eating and the mediating role of momentary fluctuations in reward anticipation and response inhibition. Normally cycling adolescent girls who have reached menarche will provide daily saliva samples for hormone analysis and be administered EMA for 35 days on mobile phones. During EMA, girls will report LOC eating and will complete measures of response inhibition and reward anticipation. This study has two specific aims. Specific Aim 1 is to characterize the association between daily hormone exposure and LOC eating in adolescent girls, and Specific Aim 2 is to examine a mediation model of daily hormone exposure and momentary RDoC constructs (i.e., response inhibition and reward anticipation) in predicting LOC eating. This work has implications for the development of new real-world biobehavioral models of LOC eating in adolescent girls within the RDoC framework, which will guide future theoretical developments and treatment for LOC eating. For example, results will provide preliminary evidence for treatment targets for novel interventions for adolescent girls—e.g., a response inhibition intervention may be needed during phases of the menstrual cycle characterized by specific hormonal profiles.

项目概要/摘要 在青春期女孩中，饮食失控（LOC）是一种与精神疾病相关的适应不良饮食行为。 发病率，包括全面综合征饮食失调的发展。然而，日常生物行为 导致LOC饮食的因素尚不清楚。卵巢激素水平是关键的生物因素 与青春期女孩饮食失调的病因有关。然而，关于每日卵巢激素如何变化的模型 暴露预示着青春期女孩的 LOC 饮食发育不成熟。两个相关的研究领域标准 (RDoC) 与饮食失调有关，包括奖励预期和反应抑制。这些过程 与卵巢激素水平的变化有关，因此，每天接触激素可能会导致 奖励预期和反应抑制的失调，可能反过来会导致LOC饮食。给定 关于青春期女孩每日激素暴露和 LOC 饮食的研究存在巨大差距，包括 瞬时中介机制，本研究的目的是检查瞬时中介机制的模式和机制 青春期女孩在整个月经周期的 LOC 饮食中卵巢激素暴露的影响。生态的 瞬时评估（EMA）与每日荷尔蒙采样相结合，用于检查每日和 每日激素暴露与 LOC 饮食之间的瞬时关联以及中介作用 奖励预期和反应抑制的瞬时波动。通常骑自行车的青春期女孩 已达到月经初潮将提供每日唾液样本进行激素分析并进行 EMA 治疗 手机上 35 天。在 EMA 期间，女孩将报告 LOC 饮食并完成应对措施 抑制和奖赏预期。这项研究有两个具体目标。具体目标 1 是表征 青春期女孩每日激素暴露与 LOC 饮食之间的关联，具体目标 2 是 检查每日激素暴露和瞬时 RDoC 结构的中介模型（即反应 抑制和奖励预期）来预测 LOC 饮食。这项工作对发展具有重要意义 RDoC 框架内青春期女孩 LOC 饮食的新现实世界生物行为模型，这将 指导 LOC 饮食的未来理论发展和治疗。例如，结果将提供 针对青春期女孩的新干预措施的治疗目标的初步证据——例如，应对措施 在以特定激素为特征的月经周期阶段，可能需要进行抑制干预 配置文件。