Southeastern Pennsylvania Adult and Pediatric Prevention Epicenter Network

项目摘要 卫生保健相关感染（HAI）和抗生素耐药性（AR）是发病的主要原因， 全世界的死亡率。需要协调一致的努力来确定新出现的HAI的流行病学和影响， AR问题，以及识别和测试新的策略来解决这些紧迫的问题。CDC预防 宾夕法尼亚大学和费城儿童医院的震中位置（即，宾夕法尼亚大学- CHOP Epicenter）参与了许多专注于HAI和AR的举措。的巨大 疾病预防控制中心的预防中心计划提供的研究支持和基础设施， 促进取得重大科学成就，部分由71篇同行评审的出版物和110篇 Penn-CHOP Epicenter小组自2011年网站成立以来的科学摘要。关于Penn-Chop Epicenter还提供了一个丰富的科学环境， 专业人员合作解决HAI和AR中最紧迫的问题。最后，Penn-CHOP集团 与其他CDC Epicenter站点和医疗保健网络广泛合作， 问题.本申请中提出的项目建立在先前工作建立的坚实基础上 从宾州-乔普调查员那里这些研究的重点是急性、急性后和门诊护理环境， 包括成人和儿童群体。最后，这些项目包括与其他网站的合作， 保健网络、公共卫生机构和区域伙伴关系。 该应用程序由6个核心项目和3个可选的合作项目组成： 核心项目 核心项目#1：艰难梭菌感染（CDI）的筛查和靶向预防 免疫功能不全（SToP-CDI） 核心项目#2：多重耐药微生物的非住宅暴露（NEXUS） 核心项目3：减少透析中的抗菌药物处方（RAPID） 核心项目#4：儿科急性期后护理中的微生物组采样，以了解多重耐药 微生物风险、抗生素效应和呼吸机相关感染（MS PAC-MAN） 核心项目#5：自然语言处理用于鼻窦炎抗生素处方（NAPS） 核心项目#6：门诊手术预防的抗生素管理（ASSURE） 可选合作项目 小型合作项目：沟通和教练，以增加管家的影响力（CACTIS） 中型合作项目：减少小儿脓毒症中万古霉素给药（REVAMP-脓毒症） 大型合作项目：粪便微生物群移植，以解决殖民和环境问题 多重耐药微生物污染（FACE-MDRO）

Project Summary Healthcare-associated infections (HAIs) and antibiotic resistance (AR) are leading causes of morbidity and mortality worldwide. Concerted efforts are required to define the epidemiology and impact of emerging HAI and AR issues, as well as identify and test novel strategies to address these urgent problems. The CDC Prevention Epicenter site at the University of Pennsylvania and the Children’s Hospital of Philadelphia (i.e., the Penn- CHOP Epicenter) has been engaged in numerous initiatives focused on HAIs and AR. The considerable research support and infrastructure provided by the CDC’s Prevention Epicenters Program has served to facilitate significant scientific achievements demonstrated in part by 71 peer-reviewed publications and 110 scientific abstracts from the Penn-CHOP Epicenter group since site inception in 2011. The Penn-CHOP Epicenter has also provided a rich scientific environment within which investigators with complementary areas of expertise collaborate to address the most urgent issues in HAI and AR. Finally, the Penn-CHOP group has collaborated extensively with other CDC Epicenter sites and healthcare networks to answer critical scientific questions. The projects proposed in this application build on the strong foundation established by prior work from the Penn-CHOP investigators. These studies focus on acute, post-acute, and outpatient care settings and include adult and pediatric populations. Finally, these projects include collaborations with other sites, health care networks, public health agencies, and regional partnerships. This application is comprised of 6 Core Projects and 3 Optional Collaborative Projects: CORE PROJECTS Core Project #1: Screening and Targeted Prophylaxis for Clostridioides difficile Infection (CDI) among Immunocompromised Hosts (SToP-CDI) Core Project #2: Non-residential Exposures to Multidrug-Resistant Organisms (NEXUS) Core Project #3: Reducing Antimicrobial Prescribing in Dialysis (RAPID) Core Project #4: Microbiome Sampling in Pediatric Post-Acute Care to Understand Multidrug-resistant Organism Risk, Antibiotic Effect, and Ventilator-associated Infection (MS PAC-MAN) Core Project #5: Natural Language Processing for Antibiotic Prescribing in Sinusitis (NAPS) Core Project #6: Antibiotic Stewardship for Ambulatory Surgery Prophylaxis (ASSURE) OPTIONAL COLLABORATIVE PROJECTS Small Collaborative Project: Communication And Coaching To Increase Steward Influence (CACTIS) Medium Collaborative Project: Reducing Vancomycin Administration in Pediatric Sepsis (REVAMP-Sepsis) Large Collaborative Project: Fecal Microbiota Transplantation to Address Colonization and Environmental Contamination with Multidrug-Resistant Organisms (FACE-MDRO)