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New Approaches to Dementia Heterogeneity

痴呆症异质性的新方法

基本信息

批准号：
10647902
负责人：
Gil Dan Rabinovici
金额：
$ 346.14万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10647902
关键词：
Acceleration Aging Alzheimer&apos s Disease American Award Basic Science Biological Biological Markers Biology Biometry Caregiver support Caring Chinese Clinical Clinical Trials Cognition Disorders Collaborations Collection Communities Creutzfeldt-Jakob Syndrome Data Dementia Diagnosis Diagnostic Disease Early Onset Alzheimer Disease Education Endowment Evaluation Film Foundations Frontotemporal Dementia Funding Generations Genetic Genomics Grant Heterogeneity Image Industry Collaboration International K-Series Research Career Programs Knowledge Latino Lead Leadership Medical Memory Minority Modeling Molecular Neurodegenerative Disorders Neurologic Neurologist Neurosciences Nurses Online Systems Pathologic Pathology Performance Physiological Policies Population Heterogeneity Process Progressive Supranuclear Palsy Proteomics Public Health Research Research Personnel Resources Sampling Science Scientist Site Specialist Specialized Center Tablets Talents Tauopathies Training United States National Institutes of Health Work brain health career catalyst clinical center clinical diagnostics clinical phenotype cohort community center corticobasal syndrome data management data sharing drug development education research ethnic diversity gender diversity health care delivery health economics health equity healthy aging improved innovation lectures normal aging novel novel strategies outreach programs recruit statistics symposium tau Proteins therapy development transcriptomics translational scientist

项目摘要

ABSTRACT The UCSF Alzheimer’s Disease Research Center (ADRC) is a major catalyst for a broad spectrum of dementia-related research conducted at UCSF and has served as a cornerstone for national and international multi-site diagnostic and treatment studies. In three previous cycles of funding under the P50 mechanism, we have organized a critical mass of dementia research and share our resources widely. We excel in clinical phenotyping, imaging, biospecimen collection, and pathologic evaluation of large and unique cohorts of early- onset AD (EOAD), frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), Creutzfeldt-Jakob disease (CJD), and healthy controls. The ADRC supports and effectively leverages additional NIH and foundation funding, philanthropy, and industry collaborations to accomplish its aims. At the UCSF Memory and Aging Center alone, ADRC clinical cohorts, data, and biosamples are currently utilized by 26 R grants, 6 K awards, 4 U grants, and 38 non-NIH grants. Projects and pilot awards have helped launch young investigator careers and major research programs. ADRC data and biosamples are utilized extensively by other ADRCs and an extensive network of collaborators. In this new P30 application, we accelerate efforts to define subtypes of healthy aging, MCI, AD, FTD, PSP, CBS, and CJD that predict specific molecular and physiological causes for dementia, improve early recognition and tracking of transitions from normal aging to dementia, and stimulate drug development and clinical trials. The ADRC will consist of seven cores: Administrative, Clinical, Data Management and Statistics, Pathology, Outreach Recruitment and Engagement, Imaging, and Biomarker and a Research Education Component. These cores will work collectively to pursue the following overarching specific aims: Aim 1: Explore the heterogeneous features of healthy aging, MCI, AD, FTD-spectrum disorders, and CJD to better understand their clinical, genetic, and molecular underpinnings. Aim 2: Leverage the valuable cohorts in the ADRC and the talented neuroscience communities at UCSF and beyond to “enhance the performance of innovative research” around diagnosis and treatment of dementia. Aim 3: Increase understanding of the unique cultural and biological features of aging Chinese and Latino Americans, while educating these communities with outreach lectures and web-based presentations. Aim 4: Develop innovative approaches to data management and biostatistics to support easy access and analysis of ADRC-related data while offering statistical support to our investigators. Aim 5: Train new leaders in dementia research with innovative education approaches and educate medical and lay communities about the heterogeneity of dementia with conferences, web-based presentations, and films. Aim 6: Create a new Biomarker Core to enhance the genomic, proteomic, and transcriptomic data captured from our extensive biospecimen collection. Aim 7: Transition to a more gender and ethnically diverse ADRC leadership by 2024.

摘要

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Chronic Traumatic Encephalopathy: A Comparison with Alzheimer's Disease and Frontotemporal Dementia.

慢性创伤性脑病：与阿尔茨海默病和额颞叶痴呆的比较。

DOI：
10.1055/s-0040-1715134
发表时间：
2020
期刊：
Seminars in neurology
影响因子：
2.7
作者：
Lesman-Segev,OritH;Edwards,Lauren;Rabinovici,GilD
通讯作者：
Rabinovici,GilD

Understanding social attachment as a window into the neural basis of prosocial behavior.

DOI：
10.3389/fneur.2023.1247480
发表时间：
2023
期刊：
Frontiers in neurology
影响因子：
3.4
作者：
通讯作者：

Corticobasal syndrome with visual hallucinations and probable REM-sleep behavior disorder: an autopsied case report of a patient with CBD and LBD pathology.

皮质基底节综合征伴视幻觉和可能的快速眼动睡眠行为障碍：一名患有 CBD 和 LBD 病理学的患者的尸检病例报告。

DOI：
10.1080/13554794.2019.1604973
发表时间：
2019
期刊：
Neurocase
影响因子：
0.8
作者：
Naasan,George;Shany-Ur,Tal;Sidhu,Manu;Barton,Cynthia;Ketelle,Robin;Shdo,SuzanneM;Kramer,JoelH;Miller,BruceL;Seeley,WilliamW
通讯作者：
Seeley,WilliamW

Rapid Isolation of Functional Synaptic Vesicles from Tissues Through Cryogrinding, Ultracentrifugation, and Size Exclusion Chromatography.

通过冷冻研磨、超速离心和尺寸排阻色谱从组织中快速分离功能性突触小泡。