Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)

密歇根生命阶段环境暴露和疾病中心 (M-LEEaD)

基本信息

  • 批准号:
    10649424
  • 负责人:
  • 金额:
    $ 151.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-04-15 至 2027-03-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT (Overall) This is a competing renewal application for the Environmental Health Sciences Core Center at the University of Michigan, submitted in the final year of our second term of support. Our Center is organized around the theme of critical windows of susceptibility to environmental exposures as important determinants of disease, forming the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). Lifestage, as used in this application, refers to clinically-recognized stages of development, mid-life, and aging that pertain to the pre- conception, prenatal, infant, child, adolescent, reproductive age adult, and aging adult periods. Our Center builds on a strong foundation of research activity and support in environmental health sciences, with 22 NIEHS grants and projects, including Outstanding New Environmental Health Scientist (ONES) and Revolutionizing Innovative, Visionary Environmental health Research (RIVER) awards and participation in Superfund and other NIEHS programs. The M-LEEaD mission is to accelerate research that defines impacts of environmental exposures during vulnerable life stages and to promote translation of findings to improve clinical and public health interventions for the mitigation of disease. Our Center implements its mission through infrastructural support of established and new investigators applying novel transdisciplinary approaches that increase understanding of how exposures target vulnerable stages of life. Support for research is provided through integrated Center programs that include a Pilot Project Program, three Facility Cores, and three Research Teams to enhance translation of research findings into applications for patients and communities to support a comprehensive and integrated environmental health paradigm. Facility Cores are: Integrated Health Sciences (IHS); Exposure Assessment (EA); and Pan-Omics and Data Science (PODS). Research Teams are organized around translational impact: Cumulative Exposures & Population Health; Climate Change & Health Disparities; and Toxicological Mechanisms & Health Outcomes. Research is coupled with engagement of stakeholder communities through the Community Engagement Core (CEC), and training of future leaders through our Career Development Program. An Administrative Core oversees the functioning of the Center. M-LEEaD strives to accomplish its mission through four specific aims: 1) Integrate institutional programs and facilities to provide structure and resources that accelerate understanding of complex relationships among environmental exposures, human biology, and disease; 2) Foster integration and cooperation among investigators across traditional and emerging disciplines to conduct research that translates to improved strategies to prevent environmentally-induced disorders; 3) Build programmatic and scientific capacity through support for scientists at critical career stages to engage in research that addresses critical questions in environmental health; and 4) Engage with affected communities via equitable partnerships in a multidirectional manner to identify community environmental health concerns and collaboratively translate research findings into action to promote health.
摘要(总体) 这是一个竞争性的更新申请环境健康科学核心中心在大学 密歇根州,在我们第二个支持任期的最后一年提交的。我们的中心是围绕主题组织的 对环境暴露敏感的关键窗口是疾病的重要决定因素, 密歇根生命阶段环境暴露和疾病中心(M-LEEaD)。生命阶段,在这个 应用,是指临床公认的发展阶段,中年和老龄化,属于前, 怀孕期、产前期、婴儿期、儿童期、青少年期、育龄期和老年期。我们中心 建立在环境健康科学研究活动和支持的坚实基础上,拥有22个NIEHS 赠款和项目,包括杰出的新环境卫生科学家(ONES)和革命 创新,有远见的环境健康研究(河流)奖项和参与超级基金和其他 NIEHS计划。M-LEEaD的使命是加速研究,确定环境的影响, 在脆弱的生命阶段的暴露,并促进翻译的结果,以改善临床和公众 为减轻疾病而采取的卫生干预措施。我们的中心通过基础设施实施其使命 支持现有和新的研究人员采用新的跨学科方法, 了解暴露如何针对生命的脆弱阶段。研究支持通过以下方式提供: 综合中心计划,包括一个试点项目计划,三个设施核心,和三个研究 团队将加强研究成果转化为患者和社区的应用程序,以支持 全面和综合的环境卫生模式。设施核心是:综合健康科学 (IHS);暴露评估(EA);和泛组学和数据科学(PODS)。研究团队组织 围绕转化影响:累积暴露与人口健康;气候变化与健康差异; 毒理学机制和健康结果。研究与利益相关者的参与相结合 通过社区参与核心(CEC)的社区,并通过我们的未来领导人的培训, 职业发展计划。一个行政核心监督中心的运作。M-LEEaD 努力通过四个具体目标完成其使命:1)整合机构方案和设施, 提供结构和资源,加速了解环境之间的复杂关系 暴露,人类生物学和疾病; 2)促进研究人员之间的整合与合作, 传统和新兴学科进行研究,转化为更好的战略,以防止 环境引起的疾病; 3)通过支持科学家建立规划和科学能力 在关键的职业生涯阶段,从事解决环境健康关键问题的研究;以及4) 通过公平的伙伴关系,以多方向的方式与受影响社区接触, 环境健康问题,并合作将研究成果转化为促进健康的行动。

项目成果

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Dana Dolinoy其他文献

Dana Dolinoy的其他文献

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{{ truncateString('Dana Dolinoy', 18)}}的其他基金

MI-CARES: The Michigan Cancer and Research on the Environment Study
MI-CARES:密歇根癌症与环境研究
  • 批准号:
    10491837
  • 财政年份:
    2021
  • 资助金额:
    $ 151.04万
  • 项目类别:
MI-CARES: The Michigan Cancer and Research on the Environment Study
MI-CARES:密歇根癌症与环境研究
  • 批准号:
    10336238
  • 财政年份:
    2021
  • 资助金额:
    $ 151.04万
  • 项目类别:
Environmental Epigenomics and Precision Environmental Health
环境表观基因组学和精准环境健康
  • 批准号:
    10376363
  • 财政年份:
    2020
  • 资助金额:
    $ 151.04万
  • 项目类别:
Environmental Epigenomics and Precision Environmental Health
环境表观基因组学和精准环境健康
  • 批准号:
    10623309
  • 财政年份:
    2020
  • 资助金额:
    $ 151.04万
  • 项目类别:
Environmental Epigenomics and Precision Environmental Health
环境表观基因组学和精准环境健康
  • 批准号:
    10162591
  • 财政年份:
    2020
  • 资助金额:
    $ 151.04万
  • 项目类别:
Perinatal Exposures, Tissue- and Cell-specific Epigenomics, & Lifecourse Outcomes
围产期暴露、组织和细胞特异性表观基因组学、
  • 批准号:
    9097203
  • 财政年份:
    2016
  • 资助金额:
    $ 151.04万
  • 项目类别:
Perinatal Exposures, Tissue- and Cell-specific Epigenomics, & Lifecourse Outcomes
围产期暴露、组织和细胞特异性表观基因组学、
  • 批准号:
    9545289
  • 财政年份:
    2016
  • 资助金额:
    $ 151.04万
  • 项目类别:
2015 Cellular and Molecular Mechanisms of Toxicology Gordon Research Conference & Gordon Research Seminar
2015毒理学细胞和分子机制戈登研究会议
  • 批准号:
    8895591
  • 财政年份:
    2015
  • 资助金额:
    $ 151.04万
  • 项目类别:
Development of piRNAs for target-specific methylation
开发用于靶标特异性甲基化的 piRNA
  • 批准号:
    8947514
  • 财政年份:
    2015
  • 资助金额:
    $ 151.04万
  • 项目类别:
Environmental exposures in early life: Epigenetics and neurodevelopment
生命早期的环境暴露:表观遗传学和神经发育
  • 批准号:
    8765374
  • 财政年份:
    2014
  • 资助金额:
    $ 151.04万
  • 项目类别:

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