2015 Cellular and Molecular Mechanisms of Toxicology Gordon Research Conference & Gordon Research Seminar

2015毒理学细胞和分子机制戈登研究会议

• 批准号: 8895591
• 负责人: Dana Dolinoy
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8895591
• 关键词: Academia; Academy; Area; Biochemical; Biological Models; Birth; Chemical Injury; Chemicals; Collaborations; Collection; Complex; Computer Simulation; Data; Decision Making; Development; Discipline; Disease; Education; Emerging Technologies; Environment; Environmental Exposure; Epigenetic Process; Event; Fostering; Future; Gender; Generations; Genomics; Goals; Government; Health; Human; Industry; International; Link; Malignant Neoplasms; Mentors; Microfluidics; Molecular; Molecular Toxicology; Nationalities; New Hampshire; Obesity; Organ Model; Outcome; Pathogenesis; Pathway interactions; Pharmacologic Substance; Poison; Policy Making; Postdoctoral Fellow; Printing; Regulation; Research; Research Personnel; Risk; Risk Assessment; Role; Safety; Science; Scientist; Senior Scientist; Staging; Stem cells; Systems Biology; Techniques; Technology; Time; Toxic effect; Toxicogenetics; Toxicology; Translations; Work; base; carcinogenesis; career; collaborative environment; educational atmosphere; experience; forging; graduate student; human disease; in vitro Model; in vivo; in vivo Model; innovation; interest; meetings; microbiome; novel; posters; programs; public health relevance; rapid technique; symposium; three-dimensional modeling; undergraduate student

 DESCRIPTION (provided by applicant): Research in basic molecular toxicology continues to underpin key innovations and advances in environmental, pharmaceutical, and industrial sciences by striving to elucidate the cellular, biochemical, and genomic mechanisms of action of toxic substances. The pace of national and international regulation of environmental and pharmaceutical exposures is rapid and methods to assess the risk of substances to human health are continually advancing. For the 2015 Gordon Research Conference (GRC) in Cellular & Molecular Mechanisms of Toxicity (CMMT), we are focusing on "Mechanistic Toxicology: The Path Forward," with the goal of incorporating research on the mechanistic basis of disease into risk decision and policymaking. The topics covered are varied and of great appeal to a broad audience of scientists with interest in toxicology. Emerging technologies including computational and 3D modeling as well as in vivo and systems biology approaches to assessing risk to human disease will be highlighted. The microbiome, the inflammasome, epigenetics, carcinogenesis, and stem cells in toxicological research are among the topics that will be highlighted at the conference. The Conference will bring together an interdisciplinary collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate and undergraduate students to present their work in poster and platform format and exchange ideas with leaders in the field. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to network and promotes trans-disciplinary collaborations in the various research areas represented. For the second time, a Gordon Research Seminar (GRS) will be held in conjunction with this conference. The 2015 GRS on "Advanced in Vitro Models in Mechanistic Toxicology" will highlight recent advancements in the development of complex in vitro models, and their utility in toxicology research and safety assessment. This is a unique forum for graduate students, postdoctoral fellows, and other scientists with comparable levels of experience and education to network and present and exchange new data and cutting edge ideas.

 描述（由申请人提供）：基础分子毒理学研究继续支持环境，制药和工业科学的关键创新和进步，努力阐明有毒物质的细胞，生物化学和基因组作用机制。国家和国际对环境和药物暴露的监管步伐很快，评估物质对人类健康风险的方法也在不断进步。对于2015年戈登研究会议（GRC）在细胞和分子机制的毒性（CMMT），我们专注于“机制毒理学：前进的道路”，与疾病的机制基础研究纳入风险决策和政策制定的目标。所涵盖的主题是多种多样的，对毒理学感兴趣的科学家的广泛受众有很大的吸引力。新兴技术，包括计算和3D建模以及体内和系统生物学方法，以评估人类疾病的风险将得到强调。毒理学研究中的微生物组，炎性体，表观遗传学，致癌作用和干细胞是会议上重点讨论的主题。会议将汇集一个跨学科的研究人员谁是在他们的领域的最前沿，并将为初级科学家和研究生和本科生提供机会，以海报和平台的形式介绍他们的工作，并与该领域的领导者交流思想。本次会议的合议气氛，与程序化的讨论会，以及在下午和晚上的非正式聚会的机会，提供了一个途径，为来自不同学科的科学家网络，并促进跨学科的合作，在各个研究领域的代表。第二次，戈登研究研讨会（GRS）将与本次会议同时举行。2015年关于“机制毒理学中的先进体外模型”的GRS将强调复杂体外模型开发的最新进展及其在毒理学研究和安全性评估中的实用性。这是一个独特的论坛，为研究生，博士后研究员和其他具有可比经验和教育水平的科学家提供网络，展示和交流新数据和前沿思想。